The altered Granger causality connection among pain-related brain networks in migraine

Ning, Yanzhe; Zheng, Ruwen; Li, Kuangshi; Zhang, Yong; Lyu, Diyang; Jia, Huang; Ren, Yi; Zou, Yihuai

doi:10.1097/md.0000000000010102

Cited by 15 publications

(15 citation statements)

References 38 publications

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“…Specifically, activity was spread over a larger extent over fronto-central and occipital regions in MA [ 175 ], and information was estimated to be flowing posterior to anterior [ 176 ]. Granger causality increased with laser stimulation (to cause pain) in those with migraine [ 177 ], and Granger causality was increased in migraine in specific areas associated with pain processing [ 178 ]. Overall, there is evidence to suggest that information spreads more readily in migraine from posterior to anterior regions, specifically in alpha and beta bands.…”

Section: Linking Models To Neural Activity During Aura (And Headache)mentioning

confidence: 99%

Migraine Visual Aura and Cortical Spreading Depression—Linking Mathematical Models to Empirical Evidence

O’Hare

Asher

Hibbard

2021

Vision

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This review describes the subjective experience of visual aura in migraine, outlines theoretical models of this phenomenon, and explores how these may be linked to neurochemical, electrophysiological, and psychophysical differences in sensory processing that have been reported in migraine with aura. Reaction–diffusion models have been used to model the hallucinations thought to arise from cortical spreading depolarisation and depression in migraine aura. One aim of this review is to make the underlying principles of these models accessible to a general readership. Cortical spreading depolarisation and depression in these models depends on the balance of the diffusion rate between excitation and inhibition and the occurrence of a large spike in activity to initiate spontaneous pattern formation. We review experimental evidence, including recordings of brain activity made during the aura and attack phase, self-reported triggers of migraine, and psychophysical studies of visual processing in migraine with aura, and how these might relate to mechanisms of excitability that make some people susceptible to aura. Increased cortical excitability, increased neural noise, and fluctuations in oscillatory activity across the migraine cycle are all factors that are likely to contribute to the occurrence of migraine aura. There remain many outstanding questions relating to the current limitations of both models and experimental evidence. Nevertheless, reaction–diffusion models, by providing an integrative theoretical framework, support the generation of testable experimental hypotheses to guide future research.

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Section: Linking Models To Neural Activity During Aura (And Headache)mentioning

confidence: 99%

Migraine Visual Aura and Cortical Spreading Depression—Linking Mathematical Models to Empirical Evidence

O’Hare

Asher

Hibbard

2021

Vision

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“…These studies are model-driven methods that require considerable prior knowledge. In this study, we used Granger causality analysis (GCA), which is a data-driven EC calculation method and can be directly applied to the resting-state data ( Liu et al, 2018 ; Ning et al, 2018 ; Shi et al, 2019 ). It has been widely used for time-directed prediction between BOLD fMRI time series to measure the causal effects among brain regions ( Jiao et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study

Dai

Zhou

et al. 2021

Front. Neurosci.

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The altered functional connectivity (FC) in amblyopia has been investigated by many studies, but the specific causality of brain connectivity needs to be explored further to understand the brain activity of amblyopia. We investigated whether the effective connectivity (EC) of children and young adults with amblyopia was altered. The subjects included 16 children and young adults with left eye amblyopia and 17 healthy controls (HCs). The abnormalities between the left/right primary visual cortex (PVC) and the other brain regions were investigated in a voxel-wise manner using the Granger causality analysis (GCA). According to the EC results in the HCs and the distribution of visual pathways, 12 regions of interest (ROIs) were selected to construct an EC network. The alteration of the EC network of the children and young adults with amblyopia was analyzed. In the voxel-wise manner analysis, amblyopia showed significantly decreased EC between the left/right of the PVC and the left middle frontal gyrus/left inferior frontal gyrus compared with the HCs. In the EC network analysis, compared with the HCs, amblyopia showed significantly decreased EC from the left calcarine fissure, posterior cingulate gyrus, left lingual gyrus, right lingual gyrus, and right fusiform gyrus to the right calcarine fissure. Amblyopia also showed significantly decreased EC from the right inferior frontal gyrus and right lingual gyrus to the left superior temporal gyrus compared with the HCs in the EC network analysis. The results may indicate that amblyopia altered the visual feedforward and feedback pathway, and amblyopia may have a greater relevance with the feedback pathway than the feedforward pathway. Amblyopia may also correlate with the feedforward of the third visual pathway.

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“…Our results showed that decreased rs-FCS of the left IFG in PDM patients had increased (normalized) after moxibustion. Previous neuroimaging studies have suggested that IFG was related to chronic pain ( Ning et al, 2018 ). The left IFG, which is reportedly involved in executive cognitive function and episodic memory, belongs to the executive control network (ECN) ( Xue et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity

Yang

Guo³

et al. 2022

Front. Neurosci.

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IntroductionPrimary dysmenorrhea (PDM) is a common gynecological disease and chronic pain disorder. Moxibustion, a form of traditional Chinese medicine therapy, has proven to be effective for PDM. However, the central mechanisms of PDM and moxibustion for PDM are still unclear. This study aims to explore the potential central mechanism of PDM and clarify the possible mechanism of moxibustion for relieving pain.Materials and methodsA total of 23 PDM patients and 23 matched healthy controls (HCs) were enrolled. For PDM patients, resting-state functional magnetic resonance imaging (rs-fMRI) data were collected pre- and post-moxibustion treatment of 3 consecutive menstrual cycles, respectively. For HCs, rs-fMRI data were collected in the baseline. The resting-state functional connectivity strength (rs-FCS) analysis and the resting-state functional connectivity (rs-FC) analysis based on the region of interest (ROI) were combined to be conducted.ResultsCompared to HCs, PDM patients showed weaker rs-FCS in the left inferior frontal gyrus (IFG). After the moxibustion treatment, rs-FCS in the left IFG was increased with clinical improvement. Then, the left IFG was chosen as ROI, and the rs-FC analysis was conducted. It showed that the left IFG rs-FC in the bilateral anterior cingulate cortex (ACC)/middle cingulate cortex (MCC), the left posterior cingulate cortex (PCC)/precuneus (PCU), and the left parahippocampal gyrus (PHG) decreased after moxibustion treatment, most of which belong to the default mode network (DMN).ConclusionOur results highlight the role of the left IFG and the DMN in PDM. Specifically, the central mechanism of moxibustion for analgesia may be related to modulating the disorders of the reappraisal and processing of pain stimuli through influencing the cognition of pain.

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The altered Granger causality connection among pain-related brain networks in migraine

Cited by 15 publications

References 38 publications

Migraine Visual Aura and Cortical Spreading Depression—Linking Mathematical Models to Empirical Evidence

Migraine Visual Aura and Cortical Spreading Depression—Linking Mathematical Models to Empirical Evidence

Altered Effective Connectivity of Children and Young Adults With Unilateral Amblyopia: A Resting-State Functional Magnetic Resonance Imaging Study

Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity

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