The alteration of surface charge characteristics of the vascular system by oral contraceptive steroids

Srinivasan, S.; J, Solash; Redner, Arlene; Möser, Christina; Farhangian, D.; Lucas, T.; Ateyeh, E.; C, McCool; Weber, Delphine; Puvan, S.I.; Jones, James R.; Sawyer, Philip N.

doi:10.1016/0010-7824(74)90020-1

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…Only M significantly lowered the zeta potential of both arteries and veins. Similar results were reported using in vitro incubation of canine blood vessels with these steroids [16].…”

Section: Animal Studiessupporting

confidence: 77%

“…At least 10 cells were ob served (5 in each direction) for each run. The detailed procedure has been elaborated in earlier publications [15,16].…”

Section: Animat Studiesmentioning

confidence: 99%

“…The electroosmotic study consists of determining the flow rate across a porous membrane, i.e.. blood vessel wall, under the influence of an electric field applied across the mem brane. The details of this experimental procedure have been described in our earlier communications [15,16).…”

Section: Animat Studiesmentioning

confidence: 99%

“…The electrophoretic mobilities (BM) of erythrocytes and platelets from human subjects were determined using Seaman's microelectrophoresis apparatus [15,16]. Cells were suspended in calcium-free Tyrode solution, and the mobility of the cells at 37 °C' under the influence of an electric field was determined.…”

Section: Animat Studiesmentioning

confidence: 99%

“…In a preliminary communication [16] we suggested that changes in the surface charge characteristics of vascular elements induced by oral contra ceptives could account for, at least in part, some of the thromboembolic side effects. We now wish to report the results of long-term studies of patients and experimental animals who were administered contraceptive steroids.…”

Section: Introductionmentioning

confidence: 99%

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Hormonal Steroids: Effects on the Vascular System

J¹,

Pérez²,

Keates³

et al. 1975

Gynecol Obstet Invest

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An increase in the incidence of thromboembolic disorders has been associated with oral contraceptive use, though the causative mechanisms remain unclear. Our studies indicate that the contraceptive steroids, irrespective of the intermediary metabolic processes involved, cause changes in the surface charge characteristics of the blood vessel wall and blood cells in the following cases: (i) in experiments using dogs, the hormonal steroids result in a greater reduction in the pore surface charge of veins than in arteries; (ii) in rats, the current induced mesenteric occlusion times are significantly lowered following administration of combined contraceptive steroids; (iii) in humans, the electrophoretic mobilities of erythrocytes and platelets from women taking Ovral and Demulen are lower than in controls, and (iv) there is no significant alteration of plasma coagulation times of women who are on injectable progestin therapy. Demulen and Ovral appear to result in a slight decrease in activated partial thromboplastin times compared to controls.

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“…Only M significantly lowered the zeta potential of both arteries and veins. Similar results were reported using in vitro incubation of canine blood vessels with these steroids [16].…”

Section: Animal Studiessupporting

confidence: 77%

“…At least 10 cells were ob served (5 in each direction) for each run. The detailed procedure has been elaborated in earlier publications [15,16].…”

Section: Animat Studiesmentioning

confidence: 99%

Section: Animat Studiesmentioning

confidence: 99%

Section: Animat Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hormonal Steroids: Effects on the Vascular System

J¹,

Pérez²,

Keates³

et al. 1975

Gynecol Obstet Invest

Self Cite

View full text Add to dashboard Cite

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Impact on the thrombogenicity of surface oxide properties of 316l stainless steel for biomedical applications

Shih

Su³

et al. 2003

J Biomedical Materials Res

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Surface oxide film on cardiovascular devices could be one of the most critical factors that determine the degree of thrombosis. Previous studies have shown that metallic wire passivated with amorphous oxide film provides excellent corrosion and scratch resistance. Investigation was undertaken to see whether this oxide film, with its unique electrochemical properties, could reduce the development of thrombosis. Results show that amorphous oxide has higher value of time constant, lower open-circuit potential, and lower degree of thrombosis. These distinguished characteristics prove amorphous oxide to be the best candidate for the cardiovascular devices. Amorphous oxide film could be a potential solution to the thrombogenic problem of cardiovascular devices.

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An Electrochemical Approach for the Solution of Cardiovascular Problems

Srinivasan

1985

Comprehensive Treatise of Electrochemistry

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The alteration of surface charge characteristics of the vascular system by oral contraceptive steroids

Cited by 12 publications

References 13 publications

Hormonal Steroids: Effects on the Vascular System

Hormonal Steroids: Effects on the Vascular System

Impact on the thrombogenicity of surface oxide properties of 316l stainless steel for biomedical applications

An Electrochemical Approach for the Solution of Cardiovascular Problems

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