The Alteration of Intestinal Microbiota Profile and Immune Response in Epinephelus coioides during Pathogen Infection

Joe, Joan Tang Xiao; Tseng, Yung‐Che; Wu, Jen Leih; Lu, Ming

doi:10.3390/life11020099

Cited by 18 publications

(11 citation statements)

References 106 publications

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“…In the present study, Vibrio (that encompasses one of the etiological agents of infection), and two other unidenti ed genera belonging to families with opportunistic taxa, Flavobacteriaceae and Vibrionaceae [39], increased their abundance in the diseased state. Another genus that increased in abundance in diseased sh was Aureispira, previously found to be highly abundant in the intestinal microbiota of grouper juveniles after iridovirus infections [40]. Similar increases in bacterial diversity after disease have been already described in other sh [e.g., 6,12,14,15], indicating that changes in microbial diversity cannot be readily expected and growth or decline of speci c taxa easily predicted.…”

Section: Discussionsupporting

confidence: 63%

Monitoring disease and antibiotic treatment in the skin microbiota of farmed seabass fingerlings

Rosado¹,

Pérez‐Losada²,

Severino

et al. 2021

Preprint

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The microbiota of fish skin is the primary barrier against disease; however, it is highly dynamic being modulated by several factors. In fish aquaculture, disease outbreaks occur mainly during early-life stages with high associated losses. Antibiotic treatments sometimes remain as the best option to control bacterial diseases, despite many reported negative impacts of its use on fish and associated microbiota. Notwithstanding, studies monitoring the effects of disease and antibiotic treatment on the microbiota of fingerlings are scarce. We used a 16S rRNA metataxonomic approach to assess the impact of a mixed infection with Photobacterium damselae ssp. piscicida and Vibrio harveyi and subsequent antibiotic treatment with flumequine, on the skin microbiota of farmed seabass Dicentrarchus labrax fingerlings. Both disease and antibiotic treatment led to a significant increase in bacterial diversity and core microbial communities and impacted microbial structure. Dysbiosis was confirmed by changes in the abundance of potential pathogenic and opportunistic bacterial taxa. Skin bacterial metabolic function was also significantly affected by flumequine administration, suggesting a detriment to fish skin health. Our results add to an increasing body of literature, showing how fish microbiome response to disease and antibiotics is not easily predicted.

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Section: Discussionsupporting

confidence: 63%

Monitoring disease and antibiotic treatment in the skin microbiota of farmed seabass fingerlings

Rosado¹,

Pérez‐Losada²,

Severino

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Pathogens, especially bacteria, are one of the important sources of stimulation. Vibrio harveyi infection has been reported to cause an increase in harmful genera and a decrease in beneficial genera in the intestinal microbiota of Epinephelus coioides ( Xiao Joe et al., 2021 ). Similar to previous reports, in the present study, high-throughput sequencing revealed altered composition of the intestinal microbiota.…”

Section: Discussionmentioning

confidence: 99%

The Damage of the Crayfish (Procambarus Clarkii) Digestive Organs Caused by Citrobacter Freundii Is Associated With the Disturbance of Intestinal Microbiota and Disruption of Intestinal-Liver Axis Homeostasis

Wang

Deng

et al. 2022

Front. Cell. Infect. Microbiol.

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As a common conditional pathogenic bacterium in nature, C. freundii has posed a threat to crayfish culture and may infect humans through consumption. However, the pathogenic mechanism of C. freundii in crayfish remains unknown, which poses difficulties for the prevention and control of the bacterium. In this study, the effects of C. freundii on the digestive organs, intestine and hepatopancreas, of crayfish were investigated by high-throughput sequencing technology combined with histological analysis and flow cytometry. The findings suggested that C. freundii caused disruption of the intestinal microbiota, leading to intestinal inflammation and disrupting intestinal integrity. Meanwhile, C. freundii infection stimulates bile acid biosynthesis in the intestinal microbiota. Transcriptomic results showed significant upregulation of hepatopancreatic lipid degradation pathway and cytochrome P450-related pathways. Follow-up experiments confirmed a decrease in intracellular lipids and an increase in ROS and apoptosis. All the results indicated the disruption of intestinal-liver axis homeostasis due to disturbed intestinal microbiota may as a potential basis for C. freundii pathopoiesis in crayfish. These results provide new insights into the pathogenic molecular mechanisms of C. freundii in the infection of crayfish.

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“…the higher-trophic-level cluster) relative to the lower-trophic-level cluster. These included several genera associated with carbohydrate consumption and metabolism ( Blautia , Marvinbryantia , Faecalibacterium and Anaerofilum [61–64]), as well as two genera that are potential opportunistic pathogenic in humans and other species ( Paeniclostridium and Terrisporobacter [65–67]) and two common marine environmental microbes (genus Methyloceanibacter [68] and family Methyloligellaceae [69]). In addition to these changes in the gut microbiota, we found that higher-trophic-level diet associated with the presence and abundance of Diphyllobothrium .…”

Section: Discussionmentioning

confidence: 99%

The relationship between dietary trophic level, parasites and the microbiome of Pacific walrus ( Odobenus rosmarus divergens )

et al. 2022

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Arctic species are likely to experience rapid shifts in prey availability under climate change, which may alter their exposure to microbes and parasites. Here, we describe fecal bacterial and macroparasite communities and assess correlations with diet trophic level in Pacific walruses harvested during subsistence hunts by members of the Native Villages of Gambell and Savoonga on St Lawrence Island, Alaska. Fecal bacterial communities were dominated by relatively few taxa, mostly belonging to phyla Fusobacteriota and Firmicutes. Members of parasite-associated phyla Nematoda, Acanthocephala and Platyhelminthes were prevalent in our study population. We hypothesized that high versus low prey trophic level (e.g. fish versus bivalves) would result in different gut bacterial and macroparasite communities. We found that bacterial community structure correlated to diet, with nine clades enriched in walruses consuming higher-trophic-level prey. While no parasite compositional differences were found at the phylum level, the cestode genus Diphyllobothrium was more prevalent and abundant in walruses consuming higher-trophic-level prey, probably because fish are the intermediate hosts for this genus. This study suggests that diet is important for structuring both parasite and microbial communities of this culturally and ecologically important species, with potential implications for population health under climate change.

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The Alteration of Intestinal Microbiota Profile and Immune Response in Epinephelus coioides during Pathogen Infection

Cited by 18 publications

References 106 publications

Monitoring disease and antibiotic treatment in the skin microbiota of farmed seabass fingerlings

Monitoring disease and antibiotic treatment in the skin microbiota of farmed seabass fingerlings

The Damage of the Crayfish (Procambarus Clarkii) Digestive Organs Caused by Citrobacter Freundii Is Associated With the Disturbance of Intestinal Microbiota and Disruption of Intestinal-Liver Axis Homeostasis

The relationship between dietary trophic level, parasites and the microbiome of Pacific walrus ( Odobenus rosmarus divergens )

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