The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alteration

Vardar, Selma Arzu; Gündüz, Özgür; Altun, Gülay Durmuş; Aydoğdu, Nurettin; Karadağ, Çetin Hakan; Torun, Neşe; Kaya, Oktay

doi:10.3109/09553002.2010.518209

Cited by 1 publication

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“…A study of lipid metabolism in radiation-exposed individuals manifested persistent dyslipidemia associated with IR (Wong 2014; Hayashi et al 2003). Asymmetric dimethylarginine (ADMA) levels in ventricle muscle of guinea pigs treated with radioactive iodine 131 I in a total dose of 1.11 × 10 6 kBq −1 kg −1 were shown to decrease (Vardar et al 2011). Experimental and clinical studies also observed a correlation between the increased ADMA levels in blood plasma and the endothelial dysfunction (Loland et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Atherosclerotic Vascular Disease in Workers Chronically Exposed to Ionizing Radiation

et al. 2021

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It is well established that cohorts of individuals exposed to ionizing radiation demonstrate increased risks of cardio- and cerebrovascular diseases. However, mechanisms of these radiation-induced diseases developing in individuals exposed to ionizing radiation remain unclear. To identify biomarkers of the atherosclerotic vessel damage in workers chronically exposed to ionizing radiation, this study considered 49 workers of the Russian nuclear production facility—the Mayak Production Association (mean age of 68.73 ± 6.92 years)—and 38 unexposed individuals (mean age of 68.84 ± 6.20 y) who had never been exposed to ionizing radiation (control). All workers were chronically exposed to combined radiation (external gamma rays and internal alpha particles). The mean cumulative liver absorbed dose from external gamma-ray exposure was 0.18 ± 0.12 Gy; the mean cumulative liver absorbed dose from internal alpha-particles was 0.14 ± 0.21 Gy. Levels of biomarkers in blood serum of the study participants were measured using the ELISA method. Elevated levels of apolipoprotein B, superoxide dismutase, monocyte chemoattractant protein 1, vascular cell adhesion protein 1, and a decreased level of endothelin-1 were observed in blood serum of Mayak PA workers chronically exposed to combined radiation compared to control individuals. A significant positive correlation was demonstrated between the vascular cell adhesion protein 1 level and cumulative liver absorbed doses from external gamma radiation and internal alpha radiation. Findings of the study suggest that molecular changes in blood of individuals occupationally exposed to ionizing radiation (combined internal exposure to alpha particles and external exposure to gamma rays) may indicate dyslipidemia, oxidative stress, inflammation, and endothelial dysfunction involved in atherosclerosis development.

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Section: Introductionmentioning

confidence: 99%

Biomarkers of Atherosclerotic Vascular Disease in Workers Chronically Exposed to Ionizing Radiation

et al. 2021

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The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alteration

Abstract: Our results indicated that RAI appears to exert an inhibitory effect on ADMA and SDMA levels of ventricular muscle. LC administration when given adjuvant to RAI therapy may cause a marked decrease in ADMA concentrations of both ventricular and gastrocnemius muscles.

Cited by 1 publication

References 30 publications

Biomarkers of Atherosclerotic Vascular Disease in Workers Chronically Exposed to Ionizing Radiation

Biomarkers of Atherosclerotic Vascular Disease in Workers Chronically Exposed to Ionizing Radiation

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