The Allergy Archives: Pioneers and Milestones

Cohen, Sheldon G.; Dworetzky, Murray; Frick, Oscar L.

doi:10.1067/mai.2003.106

Cited by 27 publications

(11 citation statements)

References 6 publications

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“…rhinitis and eczema) has increased over the last twenty years worldwide [ 1 – 4 ]. Atopy is an important risk factor for asthma, rhinitis, and eczema, related to the allergic component of these diseases [ 5 – 7 ]. The International Study of Asthma and Allergies in Childhood (ISAAC) documented high prevalence rates of allergic diseases and atopy in Latin American (LA) countries such as Brazil, Paraguay, Uruguay, Ecuador, and Peru [ 2 , 3 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city

et al. 2020

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Background Limited data are available on prevalence and associated risk factors for atopy and allergic diseases from high-altitude urban settings in Latin America. Objective To estimate the prevalence of atopy, asthma, rhinitis, and eczema, and associations with relevant risk factors in preschool children in the Andean city of Cuenca. Methods A cross-sectional study was undertaken using a representative sample of 535 children aged 3-5 years attending 30 nursery schools in the city of Cuenca, Ecuador. Data on allergic diseases and risk factors were collected by parental questionnaire. Atopy was measured by skin prick test (SPT) reactivity to a panel of relevant aeroallergens. Associations between risk factors and the prevalence of atopy and allergic diseases were estimated using multivariable logistic regression. Results Asthma symptoms were reported for 18% of children, rhinitis for 48%, and eczema for 28%, while SPT reactivity was present in 33%. Population fractions of asthma, rhinitis, and eczema attributable to SPT were 3.4%, 7.9%, and 2.9%, respectively. In multivariable models, an increased risk of asthma was observed among children with a maternal history of rhinitis (OR 1.85); rhinitis was significantly increased in children of high compared to low socioeconomic level (OR 2.09), among children with a maternal history of rhinitis (OR 2.29) or paternal history of eczema (OR 2.07), but reduced among children attending daycare

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Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city

et al. 2020

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“…Coca and R.A. Cooke in 1923, the term “atopy” became closely associated with the immunoglobulin (Ig) E molecule after its identification as the carrier of hypersensitivity. 1 However, in the context of the atopic march, it is important to note that IgE is a pathophysiologic mediator of some, but not all, “atopic” diseases. As such, it is better to consider the atopic march as a progression of allergic conditions that have common genetic and environmental predisposing factors, share the immunologic feature of one or more allergen-specific T helper type 2 (T H 2) responses, and are characterized by a “type 2” effector phase that can include generation of specific IgE, activation of granulocytes, and other innate features, such as mucous production and edema.…”

Section: Introductionmentioning

confidence: 99%

The atopic march

Hill

Spergel

2018

Annals of Allergy, Asthma & Immunology

258

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“…«Атопический марш» (АМ), впервые описанный A. F. Coca и R. A. Cooke в 1923 году [1], отражает некоторые особенности естественного развития атопического процесса. Известно, что наиболее частой формой хронической патологии у детей первых лет жизни является атопический дерматит (АтД), поражая до 15-20 % дошкольников [2].…”

Section: Introductionunclassified

Clinical and immunological features of the atopic dermatitis in children

Белан

Chueva

Sadchikova

2022

Allergol. immunol. pediatr.

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Background: “atopic march” (AM) is the natural history of allergy mostly in children. The aim: to describe the production of biomarkers of allergic inflammation in dependence on the duration of AD. Patients and methods. 94 children suffered from atopic dermatitis (AD) have been included to the study. The severity of the disease has been estimated, serum level of total IgE, IL-4, interferon gamma and sIL-2R have been estimated. Results. Coexistence of AR and AD was diagnosed in 32/94 (34.0%) patients. Less severity of AD (SCORAD 32.3 ± 9.17 score vs 22.2 ± 2.29 score, p < 0.05), but higher serum level of total IgE (Ме 123 [Q1-Q3 67–156] IU/ml vs Ме 53 [Q1-Q3 5–108] IU/ml, р < 0.001), IL-4 (Ме 12.0 [Q1-Q3 8.7–16.1] pg/ml vs Me 6.0 [Q1-Q3 2.2–12.1] pg/ml, р = 0.0399) and sIL-2R (Ме 2.1 [Q1-Q3 0–20] IU/ml vs Me 0 [Q1-Q3 0–12.9] IU/ml, р = 0.3365) are detected in comorbid patients. Eposides of wheezing are associated with additional risk of AD (OR 2.3 [95% CI 1, 18–4,54]). Discussion. The development of AR in children with AD is considered as progression of natural history of allergy. In our study it was associated with higher level of IgE, IL-4 and sIL-2R. At the same time the comorbid patients had less severity of AD. Conclusion. The coexistence of AD and AR in 3-year-old children is associated with less severity of skin symptoms but higher frequency of sensitization to inhalant allergens than in AD. AM is accompanied by higher production of Th2-dependent parameters and markers of early activation of T-cells. The probability of the AM is higher in 2 times if there were wheezing episodes in the anamnesis.

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The Allergy Archives: Pioneers and Milestones

Cited by 27 publications

References 6 publications

Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city

Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city

The atopic march

Clinical and immunological features of the atopic dermatitis in children

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