The allergenicity of genetically modified foods from genetically engineered crops

Abstract

INSTRUCTIONSCredit can now be obtained, free for a limited time, by reading the review article and completing all activity components. Please note the instructions listed below:Review the target audience, learning objectives and all disclosures.Complete the pre-test.Read the article and reflect on all content as to how it may be applicable to your practice.Complete the post-test/evaluation and claim credit earned. At this time, physicians will have earned up to 1.0 AMA PRA Category 1 Credit TM . Minimum passing score on the post-test is 70%. Overall Purpose Participants will be able to demonstrate increased knowledge of the clinical treatment of allergy/asthma/immunology and how new information can be applied to their own practices. Learning ObjectivesAt the conclusion of this activity, participants should be able to:Recognize the testing and safety features that genetically modified products are subject to in determining their allergenicity Identify the basis and rationale for genetic modification Review the evidence regarding genetically modified products and any association with food allergy Release position to control or influence the content of an activity must disclose all relevant financial relationships with any commercial interest that have occurred within the past 12 months. All identified conflicts of interest must be resolved and the educational content thoroughly vetted for fair balance, scientific objectivity, and appropriateness of patient care recommendations. It is required that disclosure be provided to the learners prior to the start of the activity. Individuals with no relevant financial relationships must also inform the learners that no relevant financial relationships exist. Learners must also be informed when off-label, experimental/ investigational uses of drugs or devices are discussed in an educational activity or included in related materials. Disclosure in no way implies that the information presented is biased or of lesser quality. It is incumbent upon course participants to be aware of these factors in interpreting the program contents and evaluating recommendations. Moreover, expressed views do not necessarily reflect the opinions of ACAAI. All identified conflicts of interest have been resolved.

Pollen food allergy syndrome (PFAS): A review of current available literature

“…82 Some concern has been raised about the potential allergenicity of genetically modified (GM) foods. A systematic review by Dunn et al 83 in 2017 concluded that "GM products do not appear to be more allergenic than their conventional counterpart as determined by IgE binding studies." They went on to say that no data exist showing consumption of GM proteins causing allergy to develop in individuals who are not allergic at baseline.…”

“…They went on to say that no data exist showing consumption of GM proteins causing allergy to develop in individuals who are not allergic at baseline. 83 The contrary may be true in that GM foods could have culprit proteins silenced, reducing their allergenicity, as reported by Dubois et al 84…”

Development of Allergenicity and Toxicity Assessment Methods for Evaluating Transgenic Sugarcane Overexpressing Sucrose–Phosphate Synthase

“…The amino acid sequences of target proteins expressed in transgenic products are compared with known allergenic proteins to search for sequence similarity or homology through computational studies [5,6]. To prove bioinformatics results, other allergenicity analysis has been carried out by certain experimental conditions, including digestion assay with heat treatment [3], in vitro gastric digestion [2,4], and evaluation of IgE [7,8]. A toxicity study, in parallel with an allergenicity assessment, has also been used to assess potential hazards to human through the acute exposure of genetically engineered products to animal model testing [4].…”

A Preliminary analysis of potential allergens in a GMO Rice: A Bioinformatics approach

“…(2) the evaluation of the newly expressed proteins [6]. Based on the latter, in this study, an in silico based allergenicity screening is demonstrated as a quick and straightforward approach to identify potential allergens from newly expressed proteins based on differentially-expressed genes that arise from a transgenic variety of rice.…”