The all2 Gene is Required for the Induction of the Purine Deamination Pathway in Schizosaccharomyces pombe

Abstract

Five mutants were isolated at the all2 gene on the basis of their inability to utilize hypoxanthine as a sole source of nitrogen. These mutants failed to utilize the purines adenine, hypoxanthine, xanthine, uric acid, allantoin and allantoic acid, although they could utilize urea and ammonium. The all2 mutants appeared to be defective in purine induction of uricase, allantoinase, allantoicase and ureidoglycollase activities but retained wild-type activity of the constitutively synthesized urease. The all2 mutations were recessive.

Functional Characterization of Alanine Racemase from Schizosaccharomyces pombe : a Eucaryotic Counterpart to Bacterial Alanine Racemase

“…Bacterial alanine racemases belong to fold type III (7,9,11), while fungal alanine racemase belongs to fold type I (4,12). This is probably a case of convergent evolution.…”

Uric acid in plants and microorganisms: Biological applications and genetics - A review

“…Fluri and Kinghorn [107] suggested that a single gene ( all2 ) is involved in uricase induction and activity in Schizosaccharomyces pombe . Five mutants were isolated at the a112 gene on the basis of their inefficacy to utilize hypoxanthine as a sole source of nitrogen.…”

Logical Identification of an Allantoinase Analog (puuE) Recruited from Polysaccharide Deacetylases

“…It is known, for example, that Pseudomonas aeruginosa possesses allantoinase activity (15), and a strain with a defective allantoinase gene, named puuE (purine utilization E), has been described (16). Similarly, allantoinase activity and a mutant strain that cannot grow on media containing allantoin as a sole nitrogen source have been identified in Schizosaccharomyces pombe (17). Yet genes coding for allantoinase do not appear to be present in the genomes of these organisms.…”