The alkylphenols 4‐nonylphenol, 4‐tert‐octylphenol and 4‐tert‐butylphenol aggravate atopic dermatitis‐like skin lesions in NC/Nga mice

Sadakane, Kaori; Ichinose, Takamichi; Takano, Hirohisa; Yanagisawa, Rie; Koike, Eiko; Inoue, Ken‐ichiro

doi:10.1002/jat.2911

Cited by 8 publications

(2 citation statements)

References 79 publications

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“…The histological changes in the livers of 4-NP-exposed Clarias gariepinus are consistent with those described in previous scholarly works 7,30 . By increasing pro-inflammatory cytokines 31 and chemotactic proteins, 4-NP could be associated with inflammatory cell infiltration in the hepatic tissues 32 . The activation of pro-apoptotic markers may be one of the negative effects of inflammation 33 .…”

Section: Discussionmentioning

confidence: 99%

Nigella sativa seeds mitigate the hepatic histo-architectural and ultrastructural changes induced by 4-nonylphenol in Clarias gariepinus

Abd-Elkareem

Sayed

Khalil

et al. 2023

Sci Rep

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Due to its prevalence in aquatic environments and potential cytotoxicity, 4-nonylphenol (4-NP) has garnered considerable attention. As a medicinal plant with numerous biological activities, Nigella sativa (black seed or black cumin) seed (NSS) is widely utilized throughout the world. Consequently, this study aimed to examine the potential protective effects of NSS against 4-NP-induced hepatotoxicity in African catfish (Clarias gariepinus). To achieve this objective, 18 fish (351 ± 3 g) were randomly divided into three equal groups for 21 days. The first group serves as a control which did not receive any treatment except the basal diet. The second and third groups were exposed to 4-NP at a dose of 0.1 mg L−1 of aquarium water and fed a basal diet only or supplemented with 2.5% NSS, respectively. The histological, histochemical, and ultrastructural features of the liver were subsequently evaluated as a damage biomarker of the hepatic tissue. Our results confirmed that 4-NP was a potent hepatotoxic agent, as 4-NP-intoxicated fish exhibited many lesions. Steatohepatitis, ballooning degeneration, sclerosing cholangitis, and coagulative necrosis of melanomacrophagecenters (MMCs) were observed. Hemosiderin, lipofuscin pigments, and proliferation of fibroblasts, kupffer cells, and telocytes were also demonstrated in the livers of 4-NP-intoxicated fish. In addition, decreased glycogen content and increased collagen deposition were observed in the hepatic tissue. Hepatocytes exhibited ultrastructural alterations in the chromatin, rough endoplasmic reticulum, smooth endoplasmic reticulum, mitochondria, lysosomes, and peroxisomes. Co-administration of 2.5% NSS to 4-NP-intoxicated fish significantly reduced these hepatotoxic effects. It nearly preserved the histological, histochemical, and ultrastructural integrity of hepatic tissue.

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Section: Discussionmentioning

confidence: 99%

Nigella sativa seeds mitigate the hepatic histo-architectural and ultrastructural changes induced by 4-nonylphenol in Clarias gariepinus

Abd-Elkareem

Sayed

Khalil

et al. 2023

Sci Rep

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“…In a murine model of atopic dermatitis (NC/Nga mice), the intraperitoneal administration of ptBP significantly exacerbated the skin lesions induced by mite allergy. It also tended to induce increases in the serum levels of IgE and antigen-specific IgG1, which suggested enhanced Th2type immune responses (Sadakane et al, 2014). ptBP may have potential effects on the systemic immune system.…”

Section: Specific Toxicitymentioning

confidence: 92%

Derivation of the permitted daily exposure value for p-tert-butylphenol as an impurity in pharmaceutical products

Ohnishi,

Sanada,

Mishima

et al. 2023

Fundam. Toxicol. Sci.

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p-tert-butyl phenol (ptBP) is an alkylphenol organic compound that is used in the production of polycarbonates, phenolic resins, epoxy resins, etc., as a polymer chain terminator. However, it can occasionally be an impurity contaminant during the chemical synthesis of active pharmaceutical ingredients. Some alkylphenols are known as carcinogens or endocrine modulators, therefore controlling the impurity level to below the permitted daily exposure (PDE) value based on the toxicological risk assessment of ptBP should be considered. Here, we propose the PDE using toxicological information primarily obtained from OECD Existing Chemicals Database. Four scenarios for the oral PDE calculation were investigated, and the lowest value, 2 mg/day, was proposed as the most appropriate control criterion of ptBP based on the depigmentation toxicity seen in black mice. The PDE for the parenteral route was concluded to be 1 mg/day by applying a default bioavailability of 50% per ICH Q3D guideline.

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The toxicity of 4-tert-butylphenol in early development of zebrafish: morphological abnormality, cardiotoxicity, and hypopigmentation

Wang

Qin

Chen

et al. 2023

Environ Sci Pollut Res

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The alkylphenols 4‐nonylphenol, 4‐tert‐octylphenol and 4‐tert‐butylphenol aggravate atopic dermatitis‐like skin lesions in NC/Nga mice

Cited by 8 publications

References 79 publications

Nigella sativa seeds mitigate the hepatic histo-architectural and ultrastructural changes induced by 4-nonylphenol in Clarias gariepinus

Nigella sativa seeds mitigate the hepatic histo-architectural and ultrastructural changes induced by 4-nonylphenol in Clarias gariepinus

Derivation of the permitted daily exposure value for p-tert-butylphenol as an impurity in pharmaceutical products

The toxicity of 4-tert-butylphenol in early development of zebrafish: morphological abnormality, cardiotoxicity, and hypopigmentation

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