The alkaloidal constituents of goda-manel (Crinum zeylanicum L.), a Sri Lankan folk medicine.

Amaryllidaceae Alkaloids from Lycoris radiata

“…As part of our search for novel and bioactive compounds, we isolated three new Amaryllidaceae alkaloids, 5,6-dehydrodihydrolycorine (1), 6b-acetoxycrinamine (2), and (þ)-8-O-acetylhomolycorine a-N-oxide (3), together with eleven known analogs from bulbs of Lycoris radiata, a Chinese folk medicine famous for the treatment of poliomyelitis [15]. The new structures were elucidated by means of spectroscopic methods, and the known compounds were identified as 6-hydroxycrinamine (4) [16], homolycorine (5) [17], dihydrolycorine (6) [18], lycorine (7) [18], 7-oxodihydrolycorine (8) [19], (þ)-hippeastrine (9) [20], 2a-hydroxy-6-O-methoxyloduline (10) [21], galanthamine (11) [22], 7-deoxynarciclasine (12) [23], pancratinine C (13) [24], and 5,6-dihydrobicolorine (14) [25]. In addition, compounds 1 -3 were evaluated for their cytotoxic activities against five human cancer cell lines.…”

Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum

“…The MeOH extract of dried leaves of C. asiaticum was partitioned between hexane, EtOAc, and BuOH, followed by repeated column chromatography and preparative HPLC to yield three alkaloids, 6-hydroxycrinamine (1) [20], lycorine (2) [21], and crinamine (3) [22] (Fig. 1).…”

Screening of plants of Amaryllidaceae and related families from Panama as sources of acetylcholinesterase inhibitors

“…Alkaloids (crimidine, flexinine, 6-hydroxypowelline, lycorine, 3-acetylhamayne, 6-hydroxycrinamine, hamayne, 6-methoxycrinamine, and zeylamine) have been reported in bulbs of Crinum zeylanicum (L.) L. by Trimino et al (1988), Doepke et al (1986), and Tsuda et al (1984), but no AChE inhibitory activity has been attributed to them. Acetylcholinesterase activity of the alkaloids hamayne, crinamine, lycorine, pseudolycorine, 6-hydroxycrinamine, and haemanthamine from Crinum jagus (Thomps.)…”