The Alimentary System and Pancrea

Gopinath, C.; Prentice, David E.; Lewis, D. J.

doi:10.1007/978-94-009-3189-3_5

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…In serum biochemistry, decrease of glucose was observed in males exposed to 1,250 ppm or 5,000 ppm, compared to that of control groups. This change could be caused by vacuolation of pancreas because pancreatic acinar cells become degranulated and atrophic with it (9) and that could result in decreased digestion of carbohydrate, precursor of glucose. TP and ALB were increased in females exposed to 5,000 ppm.…”

Section: Discussionmentioning

confidence: 99%

A Study on Subchronic Inhalation Toxicity of 1-Chloropropane

Chung¹,

Han²,

Lee³

2015

Toxicological Research

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This study was conducted to measure toxicity of 1-chloropropane (CAS No. : 540-54-5). According to the OECD Test Guideline 413 (Subchronic inhalation toxicity: 90-day study), SD rats were exposed to 0, 310, 1,250, and 5,000 ppm of 1-chloropropane for 6 h/day, 5 day/week for 13 weeks via whole-body inhalation. Mortality, clinical signs, body weights, food consumption, motor activity, ophthalmoscopy, hematology, serum chemistry, urinalysis, organ weights, gross and histopathological findings were compared between control and all tested groups. No mortality or remarkable clinical signs were examined during the study. No gross lesions or adverse effects on body weight, food consumption, motor activity, ophthalmoscopy, urinalysis, hematology, organ weights were observed in any of male or female rats in all tested groups. In serum biochemistry, glucose was significantly decreased in males of 1,250 and 5,000 ppm groups compared to control group in dose-dependent relationship. In histopathological examination, vacuolation of acinar cells was observed in pancreas of all male and female groups exposed to 1-chloropropane. In conclusion, no observable adverse effect level (NOAEL) was considered to be below 310 ppm/6 h/day, 5 day/week for rats.

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Section: Discussionmentioning

confidence: 99%

A Study on Subchronic Inhalation Toxicity of 1-Chloropropane

Chung¹,

Han²,

Lee³

2015

Toxicological Research

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The Alimentary System and Pancreas

Gopinath

Mowat

2014

Atlas of Toxicological Pathology

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Multifocal Ductal Cell Hyperplasia in the Submandibular Salivary Glands of Wistar Rats Chronically Treated with a Novel Steroidal Compound

Rijk¹,

Ravesloot²,

Hafmans

et al. 2003

Toxicol Pathol

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A high incidence of multifocal ductal hyperplasia was observed in the submandibular salivary gland of rats treated for 26 weeks with a high dose of a novel synthetic steroid with combined estrogenic and progestagenic properties. Hyperplastic foci consisted of microcystic duct-like structures lined by a single or multilayered epithelium, sometimes showing a tendency towards a cribiform growth pattern. The hyperplastic ducts were embedded in a collagen-rich stroma and surrounded by numerous myoepithelial cells. Immunohistochemical methods used for the detection of estrogen-and progesterone receptors revealed that progesterone receptors were abundantly present in the nucleus of epithelial cells within the lesions, exclusively. Estrogen receptors could not be detected in both the normal tissue and hyperplasic foci. The morphological, ultrastructural, and immunohistochemical characteristics strongly suggest that these hyperplastic lesions originated from the intercalated ducts. The rodent-specific granular duct cell was not involved in the pathogenesis as was clearly demonstrated by the lack of immunoreactive epidermal growth factor within the lesions. Lesions were not observed in studies with progestagens and estrogens alone or with other combined estrogen/progestagen compounds, suggesting that the specific ratio of estrogenic and progestagenic activity of the present steroid had played an important role in the development of ductal hyperplasia in this study. Lesions of the intercalated ducts, as described in this study, have not been reported before in the literature.

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The Alimentary System and Pancrea

Cited by 3 publications

References 55 publications

A Study on Subchronic Inhalation Toxicity of 1-Chloropropane

A Study on Subchronic Inhalation Toxicity of 1-Chloropropane

The Alimentary System and Pancreas

Multifocal Ductal Cell Hyperplasia in the Submandibular Salivary Glands of Wistar Rats Chronically Treated with a Novel Steroidal Compound

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