2018
DOI: 10.1186/s13014-018-1040-z
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The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies

Abstract: BackgroundPrediction of radiobiological response is a major challenge in radiotherapy. Of several radiobiological models, the linear-quadratic (LQ) model has been best validated by experimental and clinical data. Clinically, the LQ model is mainly used to estimate equivalent radiotherapy schedules (e.g. calculate the equivalent dose in 2 Gy fractions, EQD2), but increasingly also to predict tumour control probability (TCP) and normal tissue complication probability (NTCP) using logistic models. The selection o… Show more

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Cited by 369 publications
(327 citation statements)
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“…The MK model of Hawkins, the most recent version of the LEM, and the RMF model are examples of mechanism‐inspired models that link the RBE for reproductive cell survival to the induction and biological processing of sublethal damage, especially the DNA DSB, into more lethal forms of damage, such as chromosome aberrations. The MK, LEM, and RMF models all aim to derive the biological effects of ion radiation from the response of cells or tissues to low LET photons, thus efficiently exploiting the large amount of in vitro and in vivo data in the literature . All three models provide quantitative frameworks to estimate trends in the LQ model radiation sensitivity parameters α, β (or α/β) as a function of linear energy transfer (LET), lineal energy ( y ), or other metrics of radiation quality, such as the square of the ratio of the effective charge of the ion ( Z eff ) divided by the speed of the ion relative to the speed of light (β).…”
Section: Rbe Models and Mechanisms Of Actionmentioning
confidence: 99%
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“…The MK model of Hawkins, the most recent version of the LEM, and the RMF model are examples of mechanism‐inspired models that link the RBE for reproductive cell survival to the induction and biological processing of sublethal damage, especially the DNA DSB, into more lethal forms of damage, such as chromosome aberrations. The MK, LEM, and RMF models all aim to derive the biological effects of ion radiation from the response of cells or tissues to low LET photons, thus efficiently exploiting the large amount of in vitro and in vivo data in the literature . All three models provide quantitative frameworks to estimate trends in the LQ model radiation sensitivity parameters α, β (or α/β) as a function of linear energy transfer (LET), lineal energy ( y ), or other metrics of radiation quality, such as the square of the ratio of the effective charge of the ion ( Z eff ) divided by the speed of the ion relative to the speed of light (β).…”
Section: Rbe Models and Mechanisms Of Actionmentioning
confidence: 99%
“…Values of (α/β) R for an array of normal tissue and malignant cell populations have been measured and tabulated . Because of the limited range of values of the domain diameter, RBE 1 can be estimated with some degree of confidence from Eq.…”
Section: Rbe Models and Mechanisms Of Actionmentioning
confidence: 99%
“…Paramètres radiobiologiques pour les cancers des voies aérodigestives supérieures [3,8]  pour les tissus sains à réponse tardive : α/β = 3 Gy ;…”
Section: Cancers Des Voies Aérodigestives Supérieuresunclassified
“…Les paramètres radiobiologiques pour les cancers du poumon non à petites cellules ont été publiés [5,8]. L'impact de l'étalement dans les cancers bronchiques a été clairement mis en évidence en cas de radiothérapie exclusive, mais aussi dans le cadre des associations de chimioradiothérapie concomitante [9,10].…”
Section: Cancer Du Poumon Non à Petites Cellulesunclassified
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