The Alexander Disease Protein GFAP Drives Mitochondrial Fission
Ding Xiong,
Linghai Kong,
Ye Sing Tan
et al.
Abstract:Mitochondrial plasticity, coordinated by fission and fusion, is crucial to ensure cellular functions. Mitochondrial fission is mediated by the GTPase Drp1 at the constriction site, which is proposed to be driven by the actin-myosin contractile force. However, the mechanism that propels constriction remains unclear, and the potential involvement of additional mechanisms in this process remains an open question. Here, using structured illumination microscopy and electron microscopy, we show that the type-III int… Show more
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