The Alcohol Use Disorders Identification Test (AUDIT) and Carbohydrate‐Deficient Transferrin (CDT) in a Routine Workplace Health Examination

Hermansson, Ulric; Helander, Anders; Huss, Anders; Brandt, Lena; Rönnberg, Sten

doi:10.1111/j.1530-0277.2000.tb04589.x

Cited by 69 publications

(34 citation statements)

References 35 publications

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“…In a recent Swedish study conducted in a workplace, in which blood tests for CDT were performed during a routine health examination, the prevalence of high alcohol consumption among men was 8.9% (11). This correlates well with the general view that:/10% of the Swedish population (13% of males and 5% of females) over-consume alcohol, as revealed by a questionnaire survey conducted at a number of primary healthcare centres (12).…”

Section: Introductionmentioning

confidence: 61%

Prevalence of high alcohol and benzodiazepine consumption in sleep apnea patients studied with blood and urine tests

Nerfeldt

Gräf

Borg

et al. 2004

Acta Oto-Laryngologica

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Our findings correlate well with current views concerning alcohol and drug abuse in Sweden, and do not indicate that the frequency of such abuse is higher among OSAS patients. It should be noted that none of the patients who screened positive in the laboratory tests admitted to being alcohol or drug abusers when they consulted their physician. We recommend screening all OSAS patients for alcohol abuse using not only a questionnaire but also a laboratory test such as the CDT test.

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Section: Introductionmentioning

confidence: 61%

Prevalence of high alcohol and benzodiazepine consumption in sleep apnea patients studied with blood and urine tests

Nerfeldt

Gräf

Borg

et al. 2004

Acta Oto-Laryngologica

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“…Employees who were scheduled for a regular health examination at the company health service were given the opportunity to undergo a voluntary alcohol screening with the Alcohol Use Disorders Identification Test (AU-DIT) (19 ) and by serum CDT measurement. Those who screened negative on the AUDIT (i.e., a score Ͻ8 for men and Ͻ6 for women) (20 ) and had no indication of excessive drinking in the alcohol consumption subscale (questions no. 1-3) (21 ) were used for this study.…”

Section: Materials and Methods Serum Samplesmentioning

confidence: 99%

Improved HPLC Method for Carbohydrate-deficient Transferrin in Serum

Husa²,

2003

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Background: There is need for a reference method for transferrin glycoforms in serum to which routine immunologic methods for the alcohol marker carbohydratedeficient transferrin (CDT) can be traceable. We describe an improved HPLC method for transferrin glycoforms. Methods: Transferrin was iron-saturated by mixing the serum with ferric nitrilotriacetic acid, and lipoproteins were precipitated with dextran sulfate and calcium chloride. Separation of glycoforms was performed on a SOURCE 15Q anion-exchange column using salt gradient elution. Quantification relied on selective absorbance of the iron-transferrin complex at 470 nm. The relative amount of each glycoform was calculated as a percentage of the area under the curve, using baseline integration. Results: The HPLC system provided reproducible separation and quantification of the asialo-, monosialo-, disialo-, trisialo-, tetrasialo-, pentasialo-, and hexasialotransferrin glycoforms. Most importantly, disialo-and trisialotransferrin were almost baseline separated. The intra-and interassay CV for disialotransferrin were <5%. Serum and the pretreated samples were stable for at least 2 days at 22 or 4°C. Sera from 132 healthy controls contained [mean (SD)] 1.16 (0.25)% disialotransferrin, 4.77 (1.36)% trisialotransferrin, 80.18 (2.01)% tetrasialotransferrin, and 13.88 (1.69)% pentasialo-؉ hexasialotransferrin. In some cases of a high (>6%) trisialotransferrin, monosialotransferrin was detected at <0.25%. Asialotransferrin was not detected in control sera, but was detected in 57% of chronic heavy drinkers and in 62% of sera with >2% disialotransferrin.

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“…Future studies might consider combining the AUDIT with alcohol biomarkers to screen for problems in individuals with AUDIT scores that are open to question. A thoughtprovoking study suggesting the potential value of using biomarkers in conjunction with the AUDIT was conducted by Hermansson et al (2000). In a routine occupational health exam study using at-risk drinking as a criterion this research group found that 18% of the subjects were positive on either the AUDIT or carbohydrate deficient transferrin, a highly specific alcohol biomarker.…”

Section: Audit Issues In Particular Need Of Further Researchmentioning

confidence: 99%

The Alcohol Use Disorders Identification Test: An Update of Research Findings

Reinert

Allen

2007

Alcoholism Clin & Exp Res

1,179

922

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Background: The Alcohol Use Disorders Identification Test (AUDIT) has been extensively researched to determine its capability to accurately and practically screen for alcohol problems.Methods: During the 5 years since our previous review of the literature, a large number of additional studies have been published on the AUDIT, abbreviated versions of it, its psychometric properties, and the applicability of the AUDIT for a diverse array of populations. The current article summarizes new findings and integrates them with results of previous research. It also suggests some issues that we believe are particularly in need of further study.Results: A growing body of research evidence supports the criterion validity of English version of the AUDIT as a screen for alcohol dependence as well as for less severe alcohol problems. Nevertheless, the cut-points for effective detection of hazardous drinking as well as identification of alcohol dependence or harmful use in women need to be lowered from the originally recommended value of 8 points. The AUDIT-C, the most popular short version of the AUDIT consisting solely of its 3 consumption items, is approximately equal in accuracy to the full AUDIT. Psychometric properties of the AUDIT, such as test-retest reliability and internal consistency, are quite favorable. Continued research is urged to establish the psychometric properties of non-English versions of the AUDIT, use of the AUDIT with adolescents and with older adults, and selective inclusion of alcohol biomarkers with the AUDIT in some instances.Conclusions: Research continues to support use of the AUDIT as a means of screening for the spectrum of alcohol use disorders in various settings and with diverse populations.

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The Alcohol Use Disorders Identification Test (AUDIT) and Carbohydrate‐Deficient Transferrin (CDT) in a Routine Workplace Health Examination

Abstract: The present findings suggest that AUDIT and CDT are complementary instruments for alcohol screening in a routine workplace health examination, and each has value for identifying a different segment of the risky drinking population.

Cited by 69 publications

References 35 publications

Prevalence of high alcohol and benzodiazepine consumption in sleep apnea patients studied with blood and urine tests

Prevalence of high alcohol and benzodiazepine consumption in sleep apnea patients studied with blood and urine tests

Improved HPLC Method for Carbohydrate-deficient Transferrin in Serum

The Alcohol Use Disorders Identification Test: An Update of Research Findings

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