The Albumin Globulin Ratio in Chronic Heart Failure—Implications for Mortality

Verma, Beni; Williams, Brent A.; Honushefsky, Ashley; Kaur, Sunjeet; Doddamani, Sanjay

doi:10.1016/j.cardfail.2016.06.096

Cited by 6 publications

(4 citation statements)

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“…On the other hand, the relation between AGR and survival has not been well described in patients with chronic HF. At least, Verma et al noted the relation between AGR and outcomes in HF patients -low AGR was associated with high 6-and 12-month mortality [82]. Moreover, patients with low AGR were at higher risk of readmission due to HF [83].…”

Section: Possible Mechanismsmentioning

confidence: 99%

Total Serum Protein as an Independent Predictor of Heart Failure with Preserved Ejection Fraction in Obese Pediatric Population

Poruban¹,

Banovcinova²,

Vachalcová³

et al. 2021

austinjclincardiolog

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Objectives: We aimed to clarify the prognostic role of Total Serum Protein (TSP) in obese children with HFpEF and its using as an effective and noninvasive approach for screening of target population. Methods: In total, 587 patients who enrolled in our unique program aimed for children’s obesity treatment were referred. Among these patients, we identified and retrospectively studied 64 patients who met our criteria and compared them with 24 lean healthy subjects. Baseline examination, routine blood testing and transthoracic echocardiography were obtained. Results: We revealed that obese patients had higher TSP levels compared to them with normal weight. They also had worse echocardiographic results including a lower Left Ventricular Ejection Fraction (LVEF) and E/A ratio. Positive correlations between TSP and Pulmonary Artery Systolic Pressure (PASP), Left Atrial Volume Index (LAVI), and Interventricular Septal Systolic/Diastolic Dimension (IVSs, IVSd) and negative TSP correlations with LVEF and E/A ratio were found, too. Compared to the commonly used Albumin-to-Globulin Ratio (AGR), the TSP was a better metabolic predictor. There were more significant correlations in obese subgroup with HFpEF than to those without HFpEF. Conclusions: We first indicated that higher TSP levels are positively associated with obesity and HFpEF in children and could be used as a more easily available biomarker which provides a more-accurate HFpEF risk evaluation of obese pediatric population group than other objective indices, possibly allowing early implementation of appropriate intervention in daily practice and leads to better outcomes and early prevention in patients with higher HF risk.

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Section: Possible Mechanismsmentioning

confidence: 99%

Total Serum Protein as an Independent Predictor of Heart Failure with Preserved Ejection Fraction in Obese Pediatric Population

Poruban¹,

Banovcinova²,

Vachalcová³

et al. 2021

austinjclincardiolog

View full text Add to dashboard Cite

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“…1 Heart failure patients are a high-risk population for CIN, and these patients are prone to a decrease in albumin level that may affect the results of this study. 1,16,17 Therefore, patients with heart failure should be evaluated separately.…”

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confidence: 99%

Blood Viscosity Should Not Be Overlooked When Evaluating the Fibrinogen to Albumin Ratio

2019

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“…These patients are at high risk for the development of CIN. 13,14 Unfortunately, we did not evaluate separately these patients regarding CIN.…”

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confidence: 99%

The Ratio of Fibrinogen to Albumin as a Predictor of Contrast-Induced Nephropathy After Carotid Angiography: Reply

2019

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We would like to thank Cetin et al for their interest in our article. 1 As stated in their letter, 2 we found that the fibrinogen to albumin ratio was associated with contrast-induced nephropathy (CIN) after carotid angiography. 1 Low serum albumin level has been shown to be related to cardiovascular morbidity and mortality. 3,4 The mechanism of the association of low albumin and CIN is not clear. Some possible mechanisms are oxidative stress and increased inflammatory status. 5,6 Also, its reduced level may lead to the increased blood viscosity which is associated with endothelial dysfunction that may contribute to the development of CIN. 7 Increased fibrinogen levels are associated with mortality in acute coronary syndrome. 8 Celik et al 9 showed that there was a relationship between increased fibrinogen levels and CIN. An increase in the fibrinogen levels increased blood viscosity. Thus, microcirculation deterioration, increased endothelial shear stress, and impaired endothelial function may lead to CIN. 10,11 As they stated, therefore, the increased fibrinogen to albumin ratio may be a marker of hemoconcentration. 2 In our study, we did not calculate blood viscosity. Although The European Society of Cardiology guidelines recommend to assess the total contrast to glomerular filtration rate (GFR) ratio to predict the risk of CIN, 12 we did not measure this ratio in presented study. Low albumin level is seen commonly in heart failure. These patients are at high risk for the development of CIN. 13,14 Unfortunately, we did not evaluate separately these patients regarding CIN. We agree that it would be useful to evaluate contrast volume to GFR ratio in predicting CIN in patients who underwent carotid angiography. Also, heart failure patients should be evaluated separately.

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The Albumin Globulin Ratio in Chronic Heart Failure—Implications for Mortality

Cited by 6 publications

References 0 publications

Total Serum Protein as an Independent Predictor of Heart Failure with Preserved Ejection Fraction in Obese Pediatric Population

Total Serum Protein as an Independent Predictor of Heart Failure with Preserved Ejection Fraction in Obese Pediatric Population

Blood Viscosity Should Not Be Overlooked When Evaluating the Fibrinogen to Albumin Ratio

The Ratio of Fibrinogen to Albumin as a Predictor of Contrast-Induced Nephropathy After Carotid Angiography: Reply

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