The Ala55Val and -866G&gt;A polymorphisms of the UCP2 gene could be biomarkers for weight loss in patients who had Roux-en-Y gastric bypass

Nicoletti, Carolina Ferreira; Oliveira, Ana Paula R.P. de; Brochado, Maria José Franco; Pinhel, Marcela Augusta Souza; Oliveira, Bruno Affonso Parenti de; Marchini, Júlio Sérgio; Santos, José Ernesto dos; Wilson, Steven E.; Cury, Nathália Moreno; Araújo, Luíza Ferreira de; Silva, Wilson A.; Nonino, Carla Barbosa

doi:10.1016/j.nut.2016.07.020

Cited by 19 publications

(19 citation statements)

References 31 publications

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“…However, the total amount of weight loss shows high inter-individual variability with a large proportion of patients who achieve a large loss of weight (responder) and a subset of patients who fail to achieve the expected weight loss during the first postoperative year or even regain weight afterwards and, therefore, these patients gain little health benefit from the surgery (non-responder) [44][45][46] (Figure 1). Currently, there are several possible reasons being discussed to account for the high inter-individual variability, such as genetic, epigenetics [47], biological and clinical factors [48][49][50]. In particular, age, pre-surgical presence of T2DM, higher initial BMI and behavioural problems are associated with poor weight loss after bariatric surgery [51].…”

Section: Impact Of Gastric Bypass Surgery On Gut Microbiotamentioning

confidence: 99%

Microbial Adaptation Due to Gastric Bypass Surgery: The Nutritional Impact

2020

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Bariatric surgery leads to sustained weight loss and the resolution of obesity-related comorbidities. Recent studies have suggested that changes in gut microbiota are associated with the weight loss induced by bariatric surgery. Several studies have observed major changes in the microbial composition following gastric bypass surgery. However, there are inconsistencies between the reported alterations in microbial compositions in different studies. Furthermore, it is well established that diet is an important factor shaping the composition and function of intestinal microbiota. However, most studies on gastric bypass have not assessed the impact of dietary intake on the microbiome composition in general, let alone the impact of restrictive diets prior to bariatric surgery, which are recommended for reducing liver fat content and size. Thus, the relative impact of bariatric surgery on weight loss and gut microbiota remains unclear. Therefore, this review aims to provide a deeper understanding of the current knowledge of the changes in intestinal microbiota induced by bariatric surgery considering pre-surgical nutritional changes.

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Section: Impact Of Gastric Bypass Surgery On Gut Microbiotamentioning

confidence: 99%

Microbial Adaptation Due to Gastric Bypass Surgery: The Nutritional Impact

2020

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“…Weight-loss following RYGB and SG is highly variable with genetics estimated to contribute up to 70% of this variability (43). Candidate-gene based approaches and hypothesis-free genome-wide association studies (GWAS) have been used to identify the genes underlying this variability with limited success, in part due to low sample sizes (44)(45)(46)(47)(48). Poor post-surgery weight loss can ensue from high-allelic burden of such SNPs (47).…”

Section: Evidence For Interplay Between Genetics Eating Behaviour Anmentioning

confidence: 99%

Potential mechanisms underlying the effect of bariatric surgery on eating behaviour

Zakeri

Batterham

2018

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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“…This indicates that not only the environment but also genetic variations account for successful weight-loss therapy [ 20 , 21 ]. Several genes as well as single nucleotide polymorphisms (SNPs) are associated with obesity phenotypes and weight loss after bariatric surgery [ 21 , 22 , 23 , 24 , 25 ].…”

Section: Genetic Background and Bariatric Surgery Managementmentioning

confidence: 99%

“…Novais et al (2016) [ 24 ] evidenced that the 5-HT2C gene polymorphism (rs3813929) is associated with a greater percentage of excess body weight after RYGB. Two SNPs in the UCP2 gene (Ala55Pro and −866G > A) are considered as biomarkers of weight loss after bariatric surgery [ 22 ]. When Seip et al (2016) [ 26 ] evaluated 330 SNPs of genes involved in metabolic regulation they identified many genes that could be potential markers to discriminate changes in body mass index (BMI) one year after surgical intervention (LAGB or RYGB).…”

Section: Genetic Background and Bariatric Surgery Managementmentioning

confidence: 99%

Bariatric Surgery and Precision Nutrition

et al. 2017

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This review provides a literature overview of new findings relating nutritional genomics and bariatric surgery. It also describes the importance of nutritional genomics concepts in personalized bariatric management. It includes a discussion of the potential role bariatric surgery plays in altering the three pillars of nutritional genomics: nutrigenetics, nutrigenomics, and epigenetics. We present studies that show the effect of each patient’s genetic and epigenetic variables on the response to surgical weight loss treatment. We include investigations that demonstrate the association of single nucleotide polymorphisms with obesity phenotypes and their influence on weight loss after bariatric surgery. We also present reports on how significant weight loss induced by bariatric surgery impacts telomere length, and we discuss studies on the existence of an epigenetic signature associated with surgery outcomes and specific gene methylation profile, which may help to predict weight loss after a surgical procedure. Finally, we show articles which evidence that bariatric surgery may affect expression of numerous genes involved in different metabolic pathways and consequently induce functional and taxonomic changes in gut microbial communities. The role nutritional genomics plays in responses to weight loss after bariatric surgery is evident. Better understanding of the molecular pathways involved in this process is necessary for successful weight management and maintenance.

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The Ala55Val and -866G>A polymorphisms of the UCP2 gene could be biomarkers for weight loss in patients who had Roux-en-Y gastric bypass

Cited by 19 publications

References 31 publications

Microbial Adaptation Due to Gastric Bypass Surgery: The Nutritional Impact

Microbial Adaptation Due to Gastric Bypass Surgery: The Nutritional Impact

Potential mechanisms underlying the effect of bariatric surgery on eating behaviour

Bariatric Surgery and Precision Nutrition

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