The air–liquid interface model

Hackett, Tillie-Louise; Vasse, Gwenda F.; Does, Anne M. van der; Rae, Brady; Nawijn, Martijn C.; Heijink, Irene H.

doi:10.1016/b978-0-323-90871-9.00006-1

Cited by 1 publication

(1 citation statement)

References 184 publications

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“…The main benefit of using primary epithelial cells, rather than epithelial cell lines, is their ability to differentiate into a pseudo-stratified epithelial layer when cultured on air–liquid interface. Especially the presence of ciliated cells and mucus-producing goblet cells is important when studying the effect of particles on these epithelial layers, as mucociliary clearance is one of the most crucial mechanisms in protecting the epithelial barrier from harmful pollutants [ 45 ]. D onkers et al [ 46 ] exposed the air-side of pseudo-stratified bronchial epithelial cell layers to different sizes of polystyrene particles, high-density polyethylene, polyamide 6,6 fragments and even car tyre and ocean cleanup fragments.…”

Section: In Vitro Evidence For Immunoregulatory Cytotoxic An...mentioning

confidence: 99%

Microplastic and plastic pollution: impact on respiratory disease and health

Vasse,

Melgert

2024

Eur Respir Rev

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Throughout their lifecycle, from production to use and upon disposal, plastics release chemicals and particles known as micro- and nanoplastics (MNPs) that can accumulate in the environment. MNPs have been detected in different locations of the human body, including in our lungs. This is likely a consequence of MNP exposure through the air we breathe. Yet, we still lack a comprehensive understanding of the impact that MNP exposure may have on respiratory disease and health. In this review, we have collated the current body of evidence on the implications of MNP inhalation on human lung health fromin vitro,in vivoand occupational exposure studies. We focused on interactions between MNP pollution and different specific lung-resident cells and respiratory diseases. We conclude that it is evident that MNPs possess the capacity to affect lung tissue in disease and health. Yet, it remains unclear to which extent this occurs upon exposure to ambient levels of MNPs, emphasising the need for a more comprehensive evaluation of environmental MNP exposure levels in everyday life.

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Section: In Vitro Evidence For Immunoregulatory Cytotoxic An...mentioning

confidence: 99%