The Agonist of Adenosine A1 Receptor Induced Desensitization of delta Opioid receptor-mediated Raf-1/MEK/ERK Signaling by Feedback Phosphorylation of Raf-1-Ser289/296/301
Abstract:Our previous study found that activation of adenosine A1 receptor (A 1 R) induced phosphorylation of delta opioid receptor (DOR) and desensitization of its downstream signaling molecules, cAMP and Akt.To further investigate the effect of A 1 R agonist on DOR signaling and the underlying mechanism, we examined the effect of A 1 R activation upon binding of its agonist CHA on DOR-mediated Raf-1/MEK/ERK activation, and found that prolonged CHA exposure resulted in downregulation of DOR-mediated Raf-1/MEK/ERK sign… Show more
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