The Aging Risk and Atherosclerosis: A Fresh Look at Arterial Homeostasis

Head, Trajen; Daunert, Sylvia; Goldschmidt‐Clermont, Pascal J.

doi:10.3389/fgene.2017.00216

Cited by 127 publications

(96 citation statements)

References 112 publications

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“…Thickening of the intima due to aging compromises endothelium integrity and decreases the availability of nitric oxide, a known vasodilator. Stiffening of the arterial walls disturbs the normal blood flow that makes it easier for calcium and fatty deposits to build upon the inside of arteries which leads to further fatty build-up and narrowing of the vessel resulting in PAD [47][48][49].…”

Section: Journal Of Diabetes Researchmentioning

confidence: 99%

Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia

Akalu

Birhan

2020

Journal of Diabetes Research

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Background. Peripheral arterial disease (PAD), one of the major macrovascular complications of diabetes, is associated with cardiovascular mortality and a high rate of disability following the amputation of an extremity in diabetes patients. However, there is no data on the prevalence of PAD among type 2 diabetes patients in Ethiopia. Therefore, the current study is aimed at determining the prevalence and associated factors of PAD among type 2 diabetes patients at Debre Tabor General Hospital, Debre Tabor, Northwest Ethiopia. Methods. An institution-based cross-sectional study was conducted among type 2 diabetes mellitus patients from February 1 to August 30, 2019. A pretested interviewer-administered questionnaire was used to collect the data. The presence of stenosis and its grading were determined by color Doppler ultrasonography. Data were entered using EpiData-V.4.6 and analyzed by STATA-14. Bivariable and multivariable logistic regression was performed to identify associated factors of peripheral arterial disease. Adjusted odds ratio (AOR) and its confidence interval were estimated for potential predictors included in the final model. P≤0.05 was used to declare statistical significance. Results. The mean age of the study participants was 61.2±7.3 years. One hundred seventy-two (61.4%) patients were males. The prevalence of PAD in this study was 30.7% (95% CI (25.3-36.2%)). Of these, 37 (43%) were symptomatic. Age (AOR=1.09, 95% CI (1.03-1.16)), higher HbA1c (AOR=1.97, 95% CI (1.03-3.40)), being an ex-smoker (AOR=4.68, 95% CI (1.93-11.30)), and current cigarette smoking (AOR=5.84, 95% CI (1.79-19.04)) were significantly associated with PAD. Conclusion. The prevalence of peripheral arterial disease among type 2 diabetes patients was high. Increasing age, high HbA1c, and being cigarette smokers increase the likelihood of developing peripheral arterial disease. Clinicians should prevent PAD; screen T2DM patients who are aged, with high HbA1c, and cigarette smokers; and treat them timely.

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Section: Journal Of Diabetes Researchmentioning

confidence: 99%

Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia

Akalu

Birhan

2020

Journal of Diabetes Research

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“…Here, we demonstrate that a 40% CR regimen, beginning at 1 month of age in Fischer 344 rats, substantially retards age‐associated aortic proinflammatory phenotypic shifts in the matrix, cellular, and molecular signaling that underlies intimal and medial thickening, a most prominent clinical phenotype 1, 10, 12. In vitro, CR attenuated the age‐associated vascular smooth muscle cells (VSMC) proinflammatory phenotypic shift with a mitigation of platelet‐derived growth factor (PDGF) signaling.…”

mentioning

confidence: 79%

“…Atherosclerosis is described as “accelerated arterial aging,” characterized by a mass inflammatory fibroproliferative response of VSMCs 10, 48, 49, 50, 51. PDGF‐BB, TGF‐β1, p‐SMAD‐2/3 and collagen deposition are all involved in the initiation and progression of atherosclerosis 5, 26, 40, 41, 52, 53…”

Section: Discussionmentioning

confidence: 99%

“…Increases in the local arterial wall proinflammatory molecules, platelet‐derived growth factor (PDGF), matrix metalloproteinase type II (MMP2) and transforming growth factor beta 1 (TGF‐β1), promote cellular and matrix phenotypic shifts that contribute to aortic wall thickening and stiffening that accompany advancing age in mammals, a prominent arterial phenotype of biological aging 4, 5, 6, 7, 8, 9. Interestingly, arterial proinflammatory conditions reduces the threshold or increases the susceptibility for pernicious inflammatory arterial events under hostile conditions such as hyperlipidemia 1, 10…”

mentioning

confidence: 99%

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Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype

Wang

Zhang

Zhu

et al. 2018

JAHA

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BackgroundAging exponentially increases the incidence of morbidity and mortality of quintessential cardiovascular disease mainly due to arterial proinflammatory shifts at the molecular, cellular, and tissue levels within the arterial wall. Calorie restriction (CR) in rats improves arterial function and extends both health span and life span. How CR affects the proinflammatory landscape of molecular, cellular, and tissue phenotypic shifts within the arterial wall in rats, however, remains to be elucidated.Methods and ResultsAortae were harvested from young (6‐month‐old) and old (24‐month‐old) Fischer 344 rats, fed ad libitum and a second group maintained on a 40% CR beginning at 1 month of age. Histopathologic and morphometric analysis of the arterial wall demonstrated that CR markedly reduced age‐associated intimal medial thickening, collagen deposition, and elastin fractionation/degradation within the arterial walls. Immunostaining/blotting showed that CR effectively prevented an age‐associated increase in the density of platelet‐derived growth factor, matrix metalloproteinase type II activity, and transforming growth factor beta 1 and its downstream signaling molecules, phospho‐mothers against decapentaplegic homolog‐2/3 (p‐SMAD‐2/3) in the arterial wall. In early passage cultured vascular smooth muscle cells isolated from AL and CR rat aortae, CR alleviated the age‐associated vascular smooth muscle cell phenotypic shifts, profibrogenic signaling, and migration/proliferation in response to platelet‐derived growth factor.Conclusions CR reduces matrix and cellular proinflammation associated with aging that occurs within the aortic wall and that are attributable to platelet‐derived growth factor signaling. Thus, CR reduces the platelet‐derived growth factor–associated signaling cascade, contributing to the postponement of biological aging and preservation of a more youthful aortic wall phenotype.

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“…Based on previous findings, patients usually suffer from an event caused by rupture of the vulnerable atherosclerotic plaque when they reach 60–70 years of age; however, release of ECM fragments from the vulnerable plaque might start several decades earlier, according to C 14 dating studies of the human plaques for instance from 45 to 50 years of age (Fig. ) . Currently, conventional blood‐based biomarkers, such as C‐reactive protein (CRP), lipids and lipoproteins, are used in risk stratification as complements to the physical examination, whilst imaging and functional techniques are used to determine size and location of the plaques as well as inducible ischaemia .…”

Section: Introductionmentioning

confidence: 99%

Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

et al. 2020

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Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.

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The Aging Risk and Atherosclerosis: A Fresh Look at Arterial Homeostasis

Cited by 127 publications

References 112 publications

Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia

Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia

Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype

Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

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