The aging patient with hemophilia

Konkle, Barbara A.

doi:10.1002/ajh.23161

Cited by 23 publications

(21 citation statements)

References 89 publications

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“…Some also have to deal with inhibitors, further complicating the situation . Finally, increasing age in people with haemophilia makes them susceptible to the same medical conditions as the general population .…”

Section: Issues and Counselling Of The Adult With Haemophiliamentioning

confidence: 99%

“…However, the issues of adults or ageing persons with haemophilia (PWHs) have been less frequently discussed. Ageing with haemophilia is a relatively new phenomenon due to increased life expectancy in this population, as a result of advances in current medical treatment of haemophilia . Adulthood is a period of many personal and social changes, more so with a chronic disorder.…”

Section: Introductionmentioning

confidence: 99%

“…The current reality of haemophilia poses new challenges for psychologists and social workers, as the life expectancy of PWHs is similar to that of the general population , and the common issues related to ageing mix with the specific features of the disease. Healthcare professionals should be ready to address these scenarios.…”

Section: Introductionmentioning

confidence: 99%

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Life experience of the adult and ageing patient with haemophilia. Practical aspects for psychological support

Torres-Ortuño

Cid-Sabatel²,

Barbero

et al. 2017

Vox Sanguinis

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This article discusses, from a psychological perspective, the life experience of the adult and ageing person with haemophilia, including psychological issues, aspects of his personal and social integration, decision-making, communication and other factors that may affect treatment adherence and quality of life. The aim was to provide haematologists and healthcare staff with knowledge and resources to improve communication and support for adult persons with haemophilia, and raise awareness on psychosocial issues related to quality of life, sexuality and aspects associated with ageing with haemophilia. Adulthood is a period of many personal and social changes, and ageing with haemophilia is a relatively new phenomenon due to increased life expectancy in this population. Patients have to adapt to the disease continuously when facing new expectations, life projects and issues arising with increasing age, so the healthcare team should be ready to provide support. A good therapeutic alliance with the patient must be accompanied by assessment and counselling in aspects including satisfaction, perceived difficulties and barriers, and emotional needs. Raising awareness of all this will result in the patient benefiting from the recent improvements in treatments.

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Section: Issues and Counselling Of The Adult With Haemophiliamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Life experience of the adult and ageing patient with haemophilia. Practical aspects for psychological support

Torres-Ortuño

Cid-Sabatel²,

Barbero

et al. 2017

Vox Sanguinis

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“…The risk factors for myocardial infarction and stroke such as diabetes mellitus, obesity, hypercholesterolaemia and smoking in PWH appear to be similar to those of the general population . However, a cross‐sectional study of a cohort of 701 haemophilia patients aged 30 years or older found that the prevalence of hypertension is higher in PWH than in the general population .…”

Section: Introductionmentioning

confidence: 99%

Choosing and using non‐steroidal anti‐inflammatory drugs in haemophilia

Arachchillage

Makris

2015

Haemophilia

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The management of pain and inflammation in haemophilic arthropathy is challenging due to the lack of anti-inflammatory analgesic agents perfectly suitable for this population. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the management of arthritis due to their analgesic and anti-inflammatory effects. Their use in persons with haemophilia (PWH), however, is limited due to increased risk of bleeding mainly from the upper gastrointestinal (UGI) tract. Cyclooxygenase-2 (COX-2) selective NSAIDs which have comparable analgesic effect to traditional NSAIDs (tNSAIDs) but with less UGI bleeding have been considered to be a suitable option for treatment of haemophilic arthropathy. COX-2 inhibitors, however, have an increased in the risk of cardiovascular (CV) disease. Although the atherosclerotic burden in PWH is similar to that in the general population, the risk of CV related deaths is lower. PWH have a higher risk of GI bleeding and lower risk of thrombotic disease compared to general population. Therefore, when PWH require antiinflammatory/analgesic agents, it seems reasonable to use lowest possible dose of COX-2 inhibitors for the shortest period with a proton pump inhibitor cover (provided they do not have renal impairment or additional risk factors for CV disease) prior to starting COX-2 inhibitors. H.pylori infection should be tested for and eradicated prior to starting NSAID treatment in PWH. Furthermore, regular blood pressure and renal function test monitoring is required during COX-2 inhibitor treatment.3

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“…This disorder is caused by the deficiency of coagulation factor VIII (FVIII; haemophilia A) or FIX (haemophilia B) [1] and is classified as severe (FVIII <1 IU dL ). While the life expectancy of a patient with haemophilia is increasing and now approaches that of the general male population, they are susceptible to age-related comorbidities such as cardiovascular disease [2]. Therefore, it is necessary to manage cardiovascular events in elderly patients with haemophilia in a different manner to patients without haemophilia [3,4].…”

Section: Dear Sirmentioning

confidence: 99%