The aging kidney

Zhou, Xin J.; Rakheja, Dinesh; Yu, Xueqing; Saxena, Ramesh; Vaziri, Nosratola D.; Silva, Fred G.

doi:10.1038/ki.2008.319

Cited by 325 publications

(266 citation statements)

References 140 publications

(150 reference statements)

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“…Kidney function is known to decline with age and is exacerbated by an age-related occurrence of increased insulin resistance, inflammation, and oxidative stress (8). With regard to dietary modifications, caloric restriction (CR) has proven to be the most efficacious mode of protecting against the onset of age-related kidney damage in rodent models (24).…”

Section: Discussionmentioning

confidence: 99%

“…With increasing age, the kidney is less effective at concentrating or diluting urine and more likely to retain salt, and these dysfunctions are associated with age-associated histological changes (8). In order to investigate the effect of MR diet on the ageing kidney, renal histology was assessed in mice which had been fed the MR or control diet for a prolonged period of 190 days.…”

Section: Long-term Mr Diet Offers Some Protection Against Renal Damagementioning

confidence: 99%

“…The occurrence of age-related glucose intolerance due to defective insulin secretion, clearance and peripheral tissue responses to insulin, is also well documented (8). Kidney function is also known to significantly decline with age with an estimated average loss of glomerular filtration rate (GFR) of approximately 1 millilitre per year and an increased predisposition to glomerulosclerosis and interstitial fibrosis (9,10).…”

Section: Introductionmentioning

confidence: 99%

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Methionine restriction improves renal insulin signalling in aged kidneys

Grant

Lees

Forney

et al. 2016

Mechanisms of Ageing and Development

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Dietary methionine restriction (MR) leads to loss of adiposity, improved insulin sensitivity and lifespan extension. The possibility that dietary MR can protect the kidney from age-associated deterioration has not been addressed. Aged (10-month old) male and female mice were placed on a MR (0.172% methionine) or control diet (0.86% methionine) for 8-weeks and blood glucose, renal insulin signalling, and gene expression were assessed. Methionine restriction lead to decreased blood glucose levels compared to control-fed mice, and enhanced insulin-stimulated phosphorylation of PKB/Akt and S6 in kidneys, indicative of improved glucose homeostasis. Increased expression of lipogenic genes and downregulation of PEPCK were observed, suggesting that kidneys from MR-fed animals are more insulin sensitive. Interestingly, renal gene expression of the mitochondrial uncoupling protein UCP1 was upregulated in MR-fed animals, as were the anti-ageing and renoprotective genes Sirt1, FGF21, klotho, and β-klotho. This was associated with alterations in renal histology trending towards reduced frequency of proximal tubule intersections containing vacuoles in mice that had been on dietary MR for 190 days compared to control-fed mice, which exhibited a pre-diabetic status. Our results indicate that dietary MR may offer potential in ameliorating the renal functional decline related to ageing and other disorders associated with metabolic dysfunction by enhancing renal insulin sensitivity and renoprotective gene expression.

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Section: Discussionmentioning

confidence: 99%

Section: Long-term Mr Diet Offers Some Protection Against Renal Damagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Methionine restriction improves renal insulin signalling in aged kidneys

Grant

Lees

Forney

et al. 2016

Mechanisms of Ageing and Development

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“…62 The presence of underlying diseases, such as hypertension and diabetes, may accelerate the pathological alterations observed in aging kidneys. 2 The intimal hyperplasia in the interlobular arteries may allow for the transmission of abnormal arterial pulse waves into the smaller distal branches. 63,64 These arterial pulse waves can lead to hyaline changes in the arterioles, resulting in an acceleration of the intimal fibrosis.…”

Section: Pathological Changes In Aged Kidneysmentioning

confidence: 99%

“…2 Renal mass decreases between the ages of 30 and 80 years, with the steepest decline observed after age 50. 3,4 Fat and fibrosis scarring may replace some of the remaining functional parenchymal tissue.…”

Section: Introductionmentioning

confidence: 99%

Pathophysiology of the aging kidney and therapeutic interventions

2012

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Kidneys are among the organs affected by the aging process. Aging kidneys are characterized by progressive scarring and measurable declines in renal function. Deficiencies in renal function are associated with mortality in all populations. Therefore, if the kidneys age at an accelerated rate relative to the other organs in a particular individual, then slowing or reversing the kidney aging process may be a therapeutically useful strategy. In this review, we will discuss the physiology and pathogenesis of kidney aging and analyze potential therapeutic strategies for halting the aging process in the kidneys.

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