The aggravation of arthritis by periodontitis is dependent of <scp>IL</scp>‐17 receptor A activation

Aquino, Sabrina García de; Talbot, Jhimmy; Sônego, Fabiane; Turato, Walter Miguel; Grespan, Renata; Ávila-Campos, Mário Júlio; Cunha, Fernando; Cirelli, Joni Augusto

doi:10.1111/jcpe.12743

Cited by 31 publications

(39 citation statements)

References 53 publications

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“…Peri‐implantitis lesions showed a distinct down‐regulation of melan‐A, a melanocytic marker, and TRPM‐1/melastatin, also expressed on melanocytes, consistent with the presence of melanocytes in the periodontal ligament, which is lacking in peri‐implant tissue, and may suggest these cells play a distinct immunologic role in periodontal inflammation. Comparing periodontitis and health, the most up‐regulated GO term was “T‐helper 17 cell lineage commitment,” in agreement with previous studies, these results implied Th17 immune response as having a key role in periodontitis.…”

Section: Discussionsupporting

confidence: 90%

Long non‐coding RNA and mRNA expression profiles in peri‐implantitis vs periodontitis

Liu

et al. 2019

J of Periodontal Research

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Background and Objective:Peri-implantitis is a biofilm-mediated infectious disease that results in progressive loss of implant-supporting bone. As compared to its analogue periodontitis, peri-implantitis is generally known to be more aggressive, with comparatively rapid progression and less predictable treatment outcomes, especially when advanced. An understanding of molecular mechanisms underpinning the similarities and differences between peri-implantitis and periodontitis is essential to develop novel management strategies. This study aimed to compare long non-coding RNAs (lncRNAs) and messenger RNA (mRNA) expression profiles between peri-implantitis and periodontitis.Methods: Inflamed soft tissue from peri-implantitis and periodontitis lesions, and healthy gingival tissue controls were analyzed by microarray. Cluster graphs, gene ontology (GO) analysis, and pathway analysis were performed. Quantitative real-time PCR was employed to verify microarray results. The expression levels of RANKL and OPG in the three tissue types were also evaluated, using qRT-PCR. Coding non-coding (CNC) network analyses were performed.Results: Microarray analyses revealed 1079 lncRNAs and 1003 mRNAs as differentially expressed in peri-implantitis when compared to periodontitis. The cyclooxygenase-2 pathway was the most up-regulated biological process in peri-implantitis as compared to periodontitis, whereas hemidesmosome assembly was the most down-regulated pathway. Osteoclast differentiation was relatively up-regulated, and RANKL/OPG ratio was higher in peri-implantitis than in periodontitis. Conclusions:The study demonstrated that peri-implantitis and periodontitis exhibit significantly different lncRNA and mRNA expression profiles, suggesting that osteoclast differentiation-related pathways are comparatively more active in periimplantitis. These data highlight potential molecular targets for periodontitis and peri-implantitis therapy development. K E Y W O R D SlncRNA, microarray, peri-implantitis, periodontitis, transcriptome | 343 LIU et aL.

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Section: Discussionsupporting

confidence: 90%

Long non‐coding RNA and mRNA expression profiles in peri‐implantitis vs periodontitis

Liu

et al. 2019

J of Periodontal Research

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“…Moreover, a periodontitis rat model study showed a variable sitespecific TH17/Treg cell ratio in the oral tissues but detected a TH17 cell increase with a relative Treg cell decrease in peripheral blood, which was proposed to potentially impact development of systemic inflammatory diseases [32]. This hypothesis is supported by a recent study that found that P. gingivalis-induced periodontitis exacerbates arthritis in an IL-17RA (receptor A) dependent manner in an antigeninduced arthritis murine model [33]. The balance of TH17 cells relative to Treg cells is a central component to balancing the immune response such that pathogens are appropriately recognized, but inappropriate immune responses to self and harmless antigens are minimized [19].…”

Section: Introductionsupporting

confidence: 71%

Porphyromonas gingivalisand adverse pregnancy outcome

Reyes

Phillips

Wolfe

et al. 2017

Journal of Oral Microbiology

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Porphyromonas gingivalis is a Gram-negative, anaerobic bacterium considered to be an important pathogen of periodontal disease that is also implicated in adverse pregnancy outcome (APO). Until recently, our understanding of the role of P. gingivalis in APO has been limited and sometimes contradictory. The purpose of this review is to provide an overview of past and current research on P. gingivalis that addresses some of the controversies concerning the role of this organism in the pathogenesis of APO.ARTICLE HISTORY

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“…influence the time needed to be able to observe clinical signs (15,16,22). In this study, we decided to evaluate the effect of an acute infection with P. gingivalis through repeated intraperitoneal injections of P. gingivalis strain 381.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with RA, a correlation between the presence of P. gingivalis and anti-citrullinated protein antibodies has already been observed (12). Its detrimental effect was also confirmed in vivo in several mouse models, in which P. gingivalis infection exacerbated collagen antibody (AB)-induced arthritis through different mechanisms, including modification of the gut microbiota and the associated autoimmune response (13,14), neutrophil activation (15), or induction of bone destruction (16).…”

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confidence: 91%

Reduction of Articular and Systemic Inflammation by Kava-241 in a Porphyromonas gingivalis-Induced Arthritis Murine Model

et al. 2018

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Rheumatoid arthritis (RA) is an inflammatory disease that has been linked to several risk factors, including periodontitis. Identification of new anti-inflammatory compounds to treat arthritis is needed. We had previously demonstrated the beneficial effect of Kava-241, a kavain-derived compound, in the management of -induced periodontitis. The present study evaluated systemic and articular effects of Kava-241 in an infective arthritis murine model triggered by bacterial inoculation and primed with a collagen antibody cocktail (CIA) to induce joint inflammation and tissular destruction. Clinical inflammation score and radiological analyses of the paws were performed continuously, while histological assessment was obtained at sacrifice. Mice exposed to and a CIA cocktail and treated concomitantly with Kava-241 exhibited a reduced clinical inflammatory score and a decreased number of inflammatory cells and osteoclasts within joint. Kava-241 treatment also decreased significantly tumor necrosis factor alpha (TNF-α) in serum from mice injected with a Toll-like receptor 2 or 4 (TLR-2/4) ligand,-lipopolysaccharide (LPS). Finally, bone marrow-derived macrophages infected with and exposed to Kava-241 displayed reduced TLR-2/4, reduced mitogen-activated protein kinase (MAPK)-related signal elements, and reduced LPS-induced TNF-α factor (LITAF), all explaining the observed reduction of TNF-α secretion. Taken together, these results emphasized the novel properties of Kava-241 in the management of inflammatory conditions, especially TNF-α-related diseases such as infective RA.

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The aggravation of arthritis by periodontitis is dependent of IL‐17 receptor A activation

Abstract: The effects of P. gingivalis-induced periodontitis on arthritis are dependent on Th17 expansion and IL-17RA signalling, which lead to increased neutrophil infiltration into the joints.

Cited by 31 publications

References 53 publications

Long non‐coding RNA and mRNA expression profiles in peri‐implantitis vs periodontitis

Long non‐coding RNA and mRNA expression profiles in peri‐implantitis vs periodontitis

Porphyromonas gingivalisand adverse pregnancy outcome

Reduction of Articular and Systemic Inflammation by Kava-241 in a Porphyromonas gingivalis-Induced Arthritis Murine Model

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