The Ageing of Collagen in the Striated Muscle

Schaub, Marcus C.

doi:10.1159/000211204

Cited by 24 publications

(20 citation statements)

References 10 publications

(11 reference statements)

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“…The total collagen content has also been shown to increase in denervated ( Vecchioni and Tartarini, 1961), senile dystrophic (Lowry et ai, 1942;Dreyfus et ai, 1954), and work-induced hypertrophic (Bartsova et al, 1969) muscles of rats. The present results which show an increase in total collagen in the cardiac muscle is similar to the results of Schaub (1964a) and Knorring (1970). However, other investigators (Oken and Boucek, 1957;Laves and Correl, 1960;Montfort and Perez-Tamayo, 1962;Wegelius and Knorring, 1964) have observed no definite post natal change in the total collagen content of the myocardium.…”

Section: Resultssupporting

confidence: 89%

Age-Related Changes in Rat Muscle Collagen

Mohan

Radha²

1980

Gerontology

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Age-related studies of collagen in slow, fast and cardiac muscle of the rat indicate that different fractions of collagen as well as total collagen content vary with age and type of muscle. The total collagen level increases by 30% in slow, 40% in fast and 50% in cardiac muscle as age advances from 5 to 25 months. Collagen of the muscles of old animals is less susceptible to the collagen-degrading enzyme when compared to the young, and the activity of the enzyme decreases significantly with age. The decrease in (1) the solubility of collagen; (2) the amount of hydroxyproline released at 65°C, and (3) the increase in the resistance of collagen to the degrading enzyme seen with aging, indicates that the stability of collagen increases in these muscles with aging. Results of the study of age-related changes of different fractions of collagen of slow, fast and cardiac muscle of the rat are presented in this paper.

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Section: Resultssupporting

confidence: 89%

Age-Related Changes in Rat Muscle Collagen

Mohan

Radha²

1980

Gerontology

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“…Our results regarding the changes of the collagen content of the uterus in connection with age are in complete agreement with the data of Schaub 11964/65]. Similar changes were verified by V er za r and M eyer [1961] in tendons, by Verzar [1960] in the skin, by Schaub [1963a] in striated muscles and in the myocardium [1964], and in the parenchymal organs [1963b].…”

Section: Discussionsupporting

confidence: 91%

The Effect of Intensive Nervous Stimulation on Certain Physico-Chemical Properties of Rat Tail Tendon and Uterus Collagen

et al. 1971

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The authors simultaneously studied the physico-chemical properties of rat tail tendon (amount of labile hydroxyproline, changes of thermo-isometric tension) and uterine collagen (collagen content, total hydroxyproline, labile hydroxyproline ratio) during the biological ageing of control animals and experimental animals of identical age, exposed to long-lasting stressful stimulation. Similar changes to the tail tendon were found in the uterine collagen. The localisation of increased uterine collagen production under the given experimental conditions, besides the fibroblasts, was partly found in the smooth muscle cells transformed to fibroblastic direction as revealed by electron microscopic investigation of the myometrium.

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“…Schaub (1963) and Mohan and Radha (1975) have already reported such changes in ageing rat striated muscle. Evidence for increased cross-links in aged mammalian cardiac muscle have also been derived (Tomanek etal., 1972).…”

Section: Discussionmentioning

confidence: 79%

“…On the basis of present findings and earlier reports on other vertebrate species it is probable that there may be a common pattern of collagen ageing in vertebrates even though the rate of ageing may differ from species to species. A compari son of degree of accumulation of collagen (insoluble and total) in ageing rat skeletal muscle (Schaub, 1963;Mohan and Radha, 1975) with that of lizard reveals that the rate is higher in the reptilian species than the mammalian. This might suggest greater limitation of motor performance in aged reptilian muscle.…”

Section: Discussionmentioning

confidence: 96%

Age-Related Changes in Collagenous and Noncollagenous Proteins of Skeletal Muscle of a Short-Lived Species of Reptile

Haseeb¹,

Patnaik²

1978

Gerontology

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The collagenous/noncollagenous protein ratio in the skeletal muscle of the male garden lizard increased with advancing age, suggesting increased tensile strength of aged muscle. The solubility of collagen and the solube/insoluble collagen ratio showed a decline during ageing confirming the development of cross-linkages in the muscle collagen of ageing lizards. It is suggested that these changes are likely to disturb the efficiency of ageing muscle.

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The Ageing of Collagen in the Striated Muscle

Cited by 24 publications

References 10 publications

Age-Related Changes in Rat Muscle Collagen

Age-Related Changes in Rat Muscle Collagen

The Effect of Intensive Nervous Stimulation on Certain Physico-Chemical Properties of Rat Tail Tendon and Uterus Collagen

Age-Related Changes in Collagenous and Noncollagenous Proteins of Skeletal Muscle of a Short-Lived Species of Reptile

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