“…Despite reduced tonsil GC B cells (Lee et al, ), most elderly people can maintain the capacity to generate a diverse B‐cell repertoire (Kolar, Mehta, Wilson, & Capra, ). Similarly to TCR, the BCR repertoire in humans has been shown to decline with age and becomes dysfunctional (de Bourcy et al, ; Boyd, Liu, Wang, Martin, & Dunn‐Walters, ; Dunn‐Walters, ; Wang et al, ). A shift in T‐cell and B‐cell subtypes from naïve to memory, a significant increase in circulating regulatory CD4 T cells (Tregs) (Freitas et al, ), and changes in T‐cell and B‐cell signaling have been described in elderly individuals (Beatriz Suarez‐Alvarez, ; Le Page, Dupuis, Larbi, Mitwowski, & Fulop, ; Naylor et al, ).…”