The Age-Related Increase in Arterial Stiffness Is Augmented in Phases According to the Severity of Hypertension

Tomiyama, Hirofumi; Arai, Tomio; Koji, Yutaka; Yambe, Minoru; Motobe, Kohki; Zaydun, Glunisa; Yamamoto, Yoshio; Hori, Saburoh; Yamashina, Akira

doi:10.1291/hypres.27.465

Cited by 54 publications

(39 citation statements)

References 24 publications

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“…20,21 Although the severity of hypertension was relatively mild in the present study and these patients did not have any other atherosclerotic risk factors, the patients with hypertension had significantly higher e circ as well as conventional stiffness parameters compared with healthy subjects. In addition, the presence of hypertension was one of the independent predictors of e circ .…”

Section: Discussionmentioning

confidence: 53%

Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity

Saito¹,

Okayama

Inoue

et al. 2012

Hypertens Res

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Recently, the development of two-dimensional speckle-tracking (2DST) technology has allowed the direct measurement of the elastic parameters of the carotid arterial wall. The aims of this study were to determine the feasibility of measuring peak circumferential strain (CS) of the carotid arterial wall using 2DST and to compare this value with conventional arterial stiffness parameters in subjects with and without hypertension. The study included 90 healthy subjects and 40 age-and sex-matched patients with hypertension. The short-axis view of the right common carotid artery was recorded. The CS in the posterior region of the carotid artery was calculated by 2DST using special software and corrected by the following equation: e circ ¼ ln (systolic blood pressure/diastolic blood pressure)/CS. We simultaneously measured the stiffness index b (b) at the same location and the brachial-ankle pulse wave velocity (baPWV). Sixty randomly selected healthy subjects were used to assess the inter/ intra-observer variability of e circ and b. In healthy subjects, e circ was significantly correlated with b, age and baPWV. These correlations were slightly better than the corresponding correlations of b with age and baPWV. The hypertensive patients had a significantly larger e circ than the healthy subjects (0.112 ± 0.074 vs. 0.066 ± 0.029/%, Po0.001). The inter/intra-observer variability for e circ was significantly lower than that for b. Our data suggest that the measurement of carotid e circ using 2DST is feasible and has better reproducibility than conventional carotid arterial stiffness.

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Section: Discussionmentioning

confidence: 53%

Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity

Saito¹,

Okayama

Inoue

et al. 2012

Hypertens Res

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show abstract

“…Age (20,21), gender (22), serum lipids levels (23), renal function (24), SBP (22), pulse pressure (25), HR (26) and other cardiovascular risk factors (27−29) may influence baPWV and its progression in hypertensive patients and normotensive subjects. The results of the present study were partially consistent with those of previous studies, and established significant correlations between baseline baPWV and age, BMI, SBP and pulse pressure.…”

Section: Discussionmentioning

confidence: 99%

Selective Angiotensin Receptor Antagonism with Valsartan Decreases Arterial Stiffness Independently of Blood Pressure Lowering in Hypertensive Patients

Nakamura

Fujii²,

Hoshino³

et al. 2005

Hypertens Res

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“…Nevertheless, arterial distensibility decreases with age (26)(27)(28)(29)(30)(31)(32)(33), and the contribution of SAC to the left ventricular afterload could be increased up to 50% with the decrease in distensibility (25). In this study, SAC may have made a greater contribution than TPR to the age related-increase in afterload, because age-related change of SAC was statistically significant but that of TPR was not.…”

Section: Fig 5 Relationships Between Systemic Arterial Compliance (mentioning

confidence: 52%

Age-Related Reduction of Systemic Arterial Compliance Induces Excessive Myocardial Oxygen Consumption during Sub-Maximal Exercise

Otsuki

Maeda

Kesen³

et al. 2006

Hypertens Res

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Reduction of systemic arterial compliance (SAC) with aging increases left ventricular afterload. The present study was designed to examine whether age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise. We studied elderly (60-69 years; n =25) and senior (70-82 years; n =25) subjects. We measured SAC immediately before the start of the ramp-fashion exercise (i.e., at the end of the 20 W warm-up exercise) and the double product (DP: systolic blood pressure heart rate) during the ramp-fashion exercise (20-50 W). SAC was significantly lower in senior subjects

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The Age-Related Increase in Arterial Stiffness Is Augmented in Phases According to the Severity of Hypertension

Cited by 54 publications

References 24 publications

Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity

Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity

Selective Angiotensin Receptor Antagonism with Valsartan Decreases Arterial Stiffness Independently of Blood Pressure Lowering in Hypertensive Patients

Age-Related Reduction of Systemic Arterial Compliance Induces Excessive Myocardial Oxygen Consumption during Sub-Maximal Exercise

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