The age-related eye disease study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the age-related eye disease study report number 6

doi:10.1016/s0002-9394(01)01218-1

Cited by 483 publications

(246 citation statements)

References 11 publications

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“…All the eyes enrolled had a subfoveal PED larger than one disc area (DA), and the eyes were diagnosed with the wet-type AMD based on the diagnostic criteria proposed by the Age-Related Eye Disease Study research group [15]. According to this classification, the presence of a PED alone indicated that the eye had AMD, regardless of the existence of a CNV.…”

Section: Methodsmentioning

confidence: 99%

Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40

Baba

Kitahashi²,

Kubota-Taniai³

et al. 2012

Ophthalmologica

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Purpose: To investigate the course of subfoveal pigment epithelial detachments (PEDs) in eyes with age-related macular degeneration (AMD) and best-corrected visual acuity (BCVA) ≥20/40. Methods: Thirty-seven eyes of 35 patients with a subfoveal PED were divided into an avascular PED group (n = 11), a vascularized PED group due to polypoidal choroidal vasculopathy (PCV, n = 14) and an occult choroidal neovascularization (CNV) group (n = 12). Intravitreal bevacizumab or ranibizumab was given as needed. The BCVA, central foveal thickness, PED thickness, and lesion size were measured at baseline and at 2 years after the initial examination. Results: The BCVA did not change significantly in the avascular group, decreased from 0.06 ± 0.11 to 0.23 ± 0.15 logMAR units in the PCV group and from 0.12 ± 0.12 to 0.71 ± 0.70 logMAR units in the CNV group. At 2 years, the central foveal and PED thicknesses were not significantly different among the 3 groups, and the lesion was significantly larger in the PCV and CNV groups than in the avascular group. Conclusions: The vascularized PED cases had a poorer visual outcome than avascular PEDs with anti-VEGF drugs at the 2-year follow-up.

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Section: Methodsmentioning

confidence: 99%

Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40

Baba

Kitahashi²,

Kubota-Taniai³

et al. 2012

Ophthalmologica

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“…Two hundred normal subjects were used as a control group (normal age-matched). Inclusion criteria were: age >50 years, clear ocular media, and early and intermediate ARMD corresponding to the stages 2 and 3 of the AREDS classification [4]. AREDS stage 2 (early stage in the present study) is characterized by soft drusen with a diameter of ≥63 but <125 µm, drusen total area diameter ≥125 µm, and presence of depigmentation or increased pigment (≥125 µm) of the RPE in the central or inner macular subfields.…”

Section: Methodsmentioning

confidence: 99%

“…The Age-Related Eye Disease Study (AREDS) classified ARMD in 4 stages (early stages 1 and 2, intermediate stage 3 and advanced stage 4) based on stereoscopic color fundus photos [4]. Early and intermediate stages of ARMD are characterized by soft drusen, retinal pigment epithelium (RPE) abnormalities (hyper- and hypopigmentation) and, only in the intermediate stage, RPE atrophy not involving the center of macula.…”

Section: Introductionmentioning

confidence: 99%

“…Early and intermediate stages of ARMD are characterized by soft drusen, retinal pigment epithelium (RPE) abnormalities (hyper- and hypopigmentation) and, only in the intermediate stage, RPE atrophy not involving the center of macula. Advanced stages are characterized by choroidal neovascularization or geographic atrophy in the central subfield [4]. …”

Section: Introductionmentioning

confidence: 99%

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Detection of Macular Function Changes in Early (AREDS 2) and Intermediate (AREDS 3) Age-Related Macular Degeneration

et al. 2010

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Background/Aim: To evaluate if retinal sensitivity values obtained with a dedicated (screening) device can be used to functionally identify early and intermediate age-related macular degeneration (ARMD). Methods: A fully automatic fundus perimeter combined with an image-stabilized scanning laser ophthalmoscope was used in 200 ARMD patients (319 eyes) in 5 study sites. The age-matched control group consisted of 200 normals. Sensitivity point values (S values), mean retinal sensitivity, number of points below 24 dB (K value, cutoff for normal values) and fixation stability were recorded. Results: Of 319 eyes, 164 were classified as early (AREDS 2) and 155 as intermediate (AREDS 3) ARMD. Mean retinal sensitivity was significantly reduced in ARMD patients versus normals (p < 0.001). K values were different between normals and ARMD patients (p < 0.001). Fixation stability did not differ between early and intermediate ARMD patients. Conclusions: Macular sensitivity is reduced in patients with early and intermediate ARMD when compared to age-matched normals. These changes may be detected with a screening device.

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“…In clinical trials, based on conventional fundus photographs, GA has been defined as a sharply demarcated area of apparent absence of the RPE, larger than 175 µm in diameter, with visible choroidal vessels and no neovascular AMD [5,8,9]. Reduction of retinal thickness due to loss of outer neurosensory cell layers can be visualized by means of stereo fundus photography.…”

Section: Fundus Photographymentioning

confidence: 99%

Imaging Geographic Atrophy in Age-Related Macular Degeneration

et al. 2011

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Advances in retinal imaging technology have largely contributed to the understanding of the natural history, prognostic markers and disease mechanisms of geographic atrophy (GA) due to age-related macular degeneration. There is still no therapy available to halt or slow the disease process. In order to evaluate potential therapeutic effects in interventional trials, there is a need for precise quantification of the GA progression rate. Fundus autofluorescence imaging allows for accurate identification and segmentation of atrophic areas and currently represents the gold standard for evaluating progressive GA enlargement. By means of high-resolution spectral-domain optical coherence tomography, distinct microstructural alterations related to GA can be visualized.

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The age-related eye disease study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the age-related eye disease study report number 6

Cited by 483 publications

References 11 publications

Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40

Two-Year Course of Subfoveal Pigment Epithelial Detachment in Eyes with Age-Related Macular Degeneration and Visual Acuity Better than 20/40

Detection of Macular Function Changes in Early (AREDS 2) and Intermediate (AREDS 3) Age-Related Macular Degeneration

Imaging Geographic Atrophy in Age-Related Macular Degeneration

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