The Age-Dependent Role of Th22, Tc22, and Tc17 Cells in the Severity of Pneumonia in COVID-19 Immunopathogenesis

Çağan, Eren; Tezcan, Gülçin; Simsek, Abdurrahman; Kizmaz, Muhammed Ali; Dombaz, Fatma; Aşan, Ali; Demir, H. Ibrahim; Bal, Haldun; Yöyen-Ermiş, Diğdem; Dilektaşlı, Aslı Görek; Kazak, Esra; Akalın, Emin Halis; Oral, Haluk Barbaros; Budak, Ferah

doi:10.1089/vim.2021.0132

Cited by 10 publications

(10 citation statements)

References 39 publications

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“…In the acute phase of SARS-CoV-2 infection, which causes COVID-19, an observed increase in the frequency of Tc22 cells compared to that in healthy control groups has been observed. Tc22 cells have been associated with milder symptoms or even asymptomatic cases, suggesting a potential protective effect against SARS-CoV-2 infection 108 .…”

Section: Tc22 Cellsmentioning

confidence: 99%

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

Koh,

Lee,

Kwak

et al. 2023

Exp Mol Med

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CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant cells. Traditionally, cytotoxic T cells, characterized by their ability to produce effector cytokines and release cytotoxic granules to directly kill target cells, have been recognized as the constituents of the predominant effector T-cell subset. However, emerging evidence suggests distinct subsets of effector CD8 T cells that each exhibit unique effector functions and therapeutic potential. This review highlights recent advancements in our understanding of CD8 T-cell subsets and the contributions of these cells to various disease pathologies. Understanding the diverse roles and functions of effector CD8 T-cell subsets is crucial to discern the complex dynamics of immune responses in different disease settings. Furthermore, the development of immunotherapeutic approaches that specifically target and regulate the function of distinct CD8 T-cell subsets holds great promise for precision medicine.

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Section: Tc22 Cellsmentioning

confidence: 99%

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

Koh,

Lee,

Kwak

et al. 2023

Exp Mol Med

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“…Accordingly, compared with healthy control individuals, the IL-22 + -Tc22 and IL-22 + -Th22 numbers in adult-COVID-19 patients increased significantly, whether it is asymptomatic pneumonia, mild pneumonia, or severe pneumonia (Figure 4). These findings further suggest that in the 0-12-year-old age group with asymptomatic disease course and uncomplicated adult cases, IL-22 expressed Tc22 cells are higher, which indicates that IL-22 has a protective effect (89). In contrast, the association between the increase of Tc17 cells and the severity of COVID-19 may reveal the destructive effect of co-expression of IL-17 and IL-22.…”

Section: Il-22 In Covid-19 Patientsmentioning

confidence: 72%

The role of interleukin-22 in lung health and its therapeutic potential for COVID-19

Lin

et al. 2022

Front. Immunol.

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Although numerous clinical trials have been implemented, an absolutely effective treatment against coronavirus disease 2019 (COVID-19) is still elusive. Interleukin-22 (IL-22) has attracted great interest over recent years, making it one of the best-studied cytokines of the interleukin-10 (IL-10) family. Unlike most interleukins, the major impact of IL-22 is exclusively on fibroblasts and epithelial cells due to the restricted expression of receptor. Numerous studies have suggested that IL-22 plays a crucial role in anti-viral infections through significantly ameliorating the immune cell-mediated inflammatory responses, and reducing tissue injury as well as further promoting epithelial repair and regeneration. Herein, we pay special attention to the role of IL-22 in the lungs. We summarize the latest progress in our understanding of IL-22 in lung health and disease and further discuss maneuvering this cytokine as potential immunotherapeutic strategy for the effective manage of COVID-19.

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“…A study suggested that IL-22 expression is dependent on age, which could be a possible explanation of the effect. 29 No difference was observed for other analytes between age groups. There was no effect modification by sex.…”

Section: Discussionmentioning

confidence: 90%

Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study

Zhu,

Gebo,

Abraham

et al. 2023

The Lancet Microbe

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The Age-Dependent Role of Th22, Tc22, and Tc17 Cells in the Severity of Pneumonia in COVID-19 Immunopathogenesis

Cited by 10 publications

References 39 publications

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

The role of interleukin-22 in lung health and its therapeutic potential for COVID-19

Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study

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