The age-dependent decrease in the myogenic response of retinal arterioles as studied with the Retinal Vessel Analyzer

Jeppesen, Peter; Gregersen, Pernille A; Bek, Toke

doi:10.1007/s00417-004-0945-4

Cited by 54 publications

(59 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study we showed an association between flicker response and age; however, the coefficient of correlation was weak, which is in agreement with previous reports (30). For example, Jeppesen et al (31) reported significantly reduced diameter response in normal individuals aged Ͼ40 years.…”

Section: Discussionsupporting

confidence: 93%

Influence of Flickering Light on the Retinal Vessels in Diabetic Patients

Mandecka

Dawczynski²,

Blum³

et al. 2007

Diabetes Care

178

149

View full text Add to dashboard Cite

OBJECTIVE—Stimulation of the retina with flickering light increases retinal vessel diameters in humans. Nitric oxide is a mediator of the retinal vasodilation to flicker. The reduction of vasodilation is considered an endothelial dysfunction. We investigated the response of retinal vessels to flickering light in diabetic patients in different stages of diabetic retinopathy. RESEARCH DESIGN AND METHODS—We studied 53 healthy volunteers, 68 type 1 diabetic patients, and 172 type 2 diabetic patients. The diameter of retinal vessels was measured continuously online with the Dynamic Vessel Analyzer (DVA). Diabetic retinopathy was classified using Early Treatment Diabetic Retinopathy Study criteria. Changes in vasodilation are expressed as percent change over baseline values. RESULTS—After adjustments for age, sex, and antihypertensive treatment, the response of retinal arterioles to diffuse luminance flicker was significantly diminished in patients with type 1 diabetes compared with healthy volunteers. The vasodilation of retinal arterioles and venules decreased continuously with increasing stages of diabetic retinopathy. The retinal arterial diameter change was 3.6 ± 2.1% in the control group, 2.6 ± 2.5% in the no diabetic retinopathy group, 2.0 ± 2.7% in the mild nonproliferative diabetic retinopathy (NPDR) group, 1.6 ± 2.2% in the moderate NPDR group, 1.8 ± 1.9% in severe NPDR group, and 0.8 ± 1.6% in proliferative diabetic retinopathy group. CONCLUSIONS—Flicker responses of retinal vessels are abnormally reduced in diabetic patients. This decreased response deteriorated with increasing stages of retinopathy. The response was already reduced before clinical appearance of retinopathy. The noninvasive testing of retinal autoregulation with DVA might prove to be of value in early detection of diabetic vessel pathological changes.

show abstract

Section: Discussionsupporting

confidence: 93%

Influence of Flickering Light on the Retinal Vessels in Diabetic Patients

Mandecka

Dawczynski²,

Blum³

et al. 2007

Diabetes Care

178

149

View full text Add to dashboard Cite

show abstract

“…The observed vasoconstriction secondary to isometric exercise at baseline was comparable to previous observations in normal persons [10,22], confirming that pressure autoregulation is preserved in diabetic patients without retinopathy [23], and is in accordance with the GF around 1 as calculated from the resting diameters. The reduced vasoconstriction during hypoxia was in accordance with results from a study in normal persons [11], but may depend on the degree of hypoxia since a similar response was neither found in a study with a verified lower degree of hypoxia [10] nor in a study where a lower oxygen saturation was intended but in which a <2% contraction of retinal arterioles was achieved, and the accompanying changes in the arterial blood pressure were not monitored [3].…”

Section: Discussionsupporting

confidence: 77%

Preserved Pressure Autoregulation but Disturbed Cyclo-Oxygenase and Nitric Oxide Effects on Retinal Arterioles during Acute Hypoxia in Diabetic Patients without Retinopathy

Petersen

Bek²

2016

Ophthalmologica

Self Cite

View full text Add to dashboard Cite

Background: Acute hypoxia induces retinal vasodilatation, which depends on cyclooxygenase (COX) products and nitric oxide (NO) in vitro. However, it is unknown whether these mechanisms are active in diabetic patients and may contribute to the development of diabetic retinopathy. Methods: The Dynamic Vessel Analyzer was used to study the diameter regulation in retinal vessels during hypoxia in type 1 diabetic patients without retinopathy. The influence of NO and COX synthesis inhibition on the diameter of larger retinal vessels was studied during hypoxia, during isometric exercise and during flicker stimulation. Results: Increased arterial blood pressure during L-NMMA infusion and isometric exercise were paralleled by constriction of the retinal arterioles suggesting normal pressure autoregulation. Hypoxia significantly reduced the diameter responses during isometric exercise and during flicker stimulation as compared to normal persons. Conclusion: The findings support that changes in metabolic autoregulation develop before changes in pressure autoregulation in diabetic patients.

show abstract

“…The lack of predictive value of age on the therapeutic outcome may be due to an increased stiffening of the retinal vascular walls with age that hinders dilatation when the blood pressure increases. 25 The findings of the present study are limited by several factors. Thus, the measurements of oxygen saturation and diameters in the larger retinal vessels were not performed repeatedly, and, therefore, an influence of dynamic properties of vascular function to the observed effects may have been overlooked.…”

Section: Discussionmentioning

confidence: 90%

The Systemic Blood Pressure and Oxygen Saturation in Retinal Arterioles Predict the Effect of Intravitreal Anti-VEGF Treatment on Diabetic Maculopathy

Bek

Jørgensen

2016

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

The age-dependent decrease in the myogenic response of retinal arterioles as studied with the Retinal Vessel Analyzer

Abstract: Studies on autoregulation in retinal disease should consider the normal age-related decrease in diameter response of retinal arterioles when the blood pressure is changed.

Cited by 54 publications

References 22 publications

Influence of Flickering Light on the Retinal Vessels in Diabetic Patients

Influence of Flickering Light on the Retinal Vessels in Diabetic Patients

Preserved Pressure Autoregulation but Disturbed Cyclo-Oxygenase and Nitric Oxide Effects on Retinal Arterioles during Acute Hypoxia in Diabetic Patients without Retinopathy

The Systemic Blood Pressure and Oxygen Saturation in Retinal Arterioles Predict the Effect of Intravitreal Anti-VEGF Treatment on Diabetic Maculopathy

Contact Info

Product

Resources

About