The African strychnos species and their alkaloids: A review

Ohiri, F. C.; Verpoorte, Robert; Svendsen, A. Baerheim

doi:10.1016/0378-8741(83)90032-6

Cited by 32 publications

(17 citation statements)

References 70 publications

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“…The chemical composition of many Strychnos had already been partially analysed (Bisset and Phillipson, 1976;Ohiri et al, 1983;Quetin-Leclercq et al, 1990;Delaude and Delaude, 1997;Philippe et al, 2004). A large diversity in alkaloids is generally found in Strychnos species, with an average of about 20 different alkaloids, the richest containing more than 40.…”

Section: Resultsmentioning

confidence: 98%

In vitro screening of some Strychnos species for antiplasmodial activity

Gilles

Angenot

Mol

et al. 2005

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 98%

In vitro screening of some Strychnos species for antiplasmodial activity

Gilles

Angenot

Mol

et al. 2005

Journal of Ethnopharmacology

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“…C. sieberiana was also shown to contain anthracenic derivatives (Duquenois and Anton, 1968) which could also explain a part of the observed activity as a recent study has shown that azaanthraquinone has interesting effects on Trypanosoma congolense (Nok, 2002). Very low concentrations of alkaloids have been reported in the leaves of P. laxiflora and S. spinosa (Bisset and Phillipson, 1971;Kerharo and Adam, 1974;Oguakwa et al, 1980;Ohiri et al, 1983). As a recent paper analysed the antitrypanosomal activity of alkaloids from different types, some of which being active, we tried to detect alkaloids using thin-layer chromatography but failed to demonstrate their presence in these two crude methylene chloride leaf extracts (Merschjohann et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants

Hoet

Opperdoes

Brun

et al. 2004

Journal of Ethnopharmacology

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The in vitro antitrypanosomal activity of methylene chloride, methanol and aqueous extracts of the leaves and twigs of five plant species traditionally used in Benin for the treatment of sleeping sickness were evaluated on Trypanosoma brucei brucei and their selectivity was analysed on Leishmania mexicana mexicana and J774 macrophage-like murine cells. The results showed that the four most active extracts had MIC values ≤19 g/ml (Hymenocardia acida twig and leaf, Strychnos spinosa leaf, Trichilia emetica leaf methylene chloride extracts).All these extracts had a lower activity on L. m. mexicana and J774 cells. Determination of the IC 50 values of the methylene chloride leaf extracts on two strains of trypanosomes (T. b. brucei and T. b. rhodesiense) and two mammalian cell lines (L6 and J774 cells) showed that all extracts possessed some antitrypanosomal activity with IC 50 's ranging from 1.5 to 39 g/ml. All were also toxic to the mammalian cells, but usually with higher IC 50 's. The only exception was the S. spinosa methylene chloride leaf extract which had no toxicity on J774 cells. Although tannins have been identified in most of the species studied, they could not be detected in the most active extracts, just as alkaloids. The presence of flavonoids and quinones may at least in part explain the observed activities of some of the active extracts.

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“…Several plants containing MIAs are used in traditional medicine, or in other ethnobotanical practices, such as hunting and fishing, and for defense purposes, due to the molecules present having broad‐spectrum biological activities . Although many of these plants have been investigated from the phytochemical viewpoint, some families of species are almost unexplored, especially in the Amazon region.…”

Section: Introductionmentioning

confidence: 99%

Molecular networking‐based dereplication of strictosidine‐derived monoterpene indole alkaloids from the curare ingredient Strychnos peckii

Santos

Angolini

Neves

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Monoterpene indole alkaloids (MIAs) are a large group of biologically active compounds produced by hundreds of plant species in numerous plant families, such as Apocynaceae, Loganiaceae and Rubiaceae. Although this diversity is biosynthetically intermediated by strictosidine, there are no works focused on the fragmentation patterns under collision‐induced dissociation of strictosidine‐derived alkaloids. Methods Initially, the alkaloid fingerprint of Strychnos peckii was established using leaf spray with tandem mass spectrometry (LS‐MS/MS). Then, high‐performance liquid chromatography coupled to tandem mass spectrometry (HPLC/MS/MS) analyses were carried out to focus on the patterns of neutral losses in product ion scan experiments with the leaf aqueous extract. Finally, the product ion spectra from a set of presumable strictosidine‐type derivatives were analyzed and organized via molecular networking (MN), and dereplicated by manual interpretation of MS/MS spectra. Results LS‐MS/MS allowed the tentative identification of strictosidine‐derived alkaloids in the leaves of S. peckii, showing useful neutral losses for the dereplication of strictosidine analogues by HPLC/MS/MS experiments. The use of MN combined with manual interpretation of the fragmentation patterns highlighted characteristic fragmentation pathways, and allowed the tentative identification of strictosidine, desoxycordifoline, strictosidinic acid, 10‐hydroxystrictosidine, 5‐carboxystrictosidine, lyaloside, 3,4‐dehydrostrictosidine and strictosidine lactam. Conclusions The use of MN combined with the analysis of the fragmentation patterns proved to be a useful strategy for the dereplication of strictosidine‐derived MIAs from S. peckii, highlighting known and unprecedented structures, as well as useful diagnostic product ions. Therefore, this workflow is an effective approach for the characterization of strictosidine‐type alkaloids in future dereplication works.

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The African strychnos species and their alkaloids: A review

Cited by 32 publications

References 70 publications

In vitro screening of some Strychnos species for antiplasmodial activity

In vitro screening of some Strychnos species for antiplasmodial activity

In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants

Molecular networking‐based dereplication of strictosidine‐derived monoterpene indole alkaloids from the curare ingredient Strychnos peckii

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