The Aetiopathogenesis of Chronic Relapsing Pancreatitis

Geevarghese, P. J.; Pillai, Viswapriya; Pitchumoni, C. S.

doi:10.1159/000389223

Cited by 9 publications

(12 citation statements)

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“…It is not a matter of large families with numerous cases but two cases in the same family, uncle and nephew in our patients, two brothers (Leger, Perrotin, Detrie, Lebel, Meyer, and Lemaigre, 1962), father and daughter (Fitzgerald et al, 1963), mother and daughter (Koch and Bohn, 1963). Geevarghese, Pillai, and Pitchumoni (1963) found in 100 cases of calcifying pancreatitis three families in which two brothers, a father and a son, and a brother and a sister were affected.…”

Section: Discussionmentioning

confidence: 46%

Observations on 205 confirmed cases of acute pancreatitis, recurring pancreatitis, and chronic pancreatitis.

Sarles¹,

Sarles²,

Camatte³

et al. 1965

Gut

399

140

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Section: Discussionmentioning

confidence: 46%

Observations on 205 confirmed cases of acute pancreatitis, recurring pancreatitis, and chronic pancreatitis.

Sarles¹,

Sarles²,

Camatte³

et al. 1965

Gut

399

140

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“…The hypothesis is that hydrogen cyanide, released from the plant after ingestion, damages the exocrine pancreas. The theory has been discredited by the lack of a cassava connection in some tropical areas [6,7], the apparently innocuous nature of cassava in other zones [8], and the declining incidence of chronic pancreatitis in the province of Kerala, South India, in the past two decades [9], although dietary patterns have not changed in this region where the cassava connection was first postulated [2]. Other xenobiotics have now been identified and may be more relevant [7], for example, petrochemical products in fumes from kerosene lamps and cookers, or substances in vehicle emissions; smoke from cigarettes and firewood, and cooking oils high in C18:2 fatty acids.…”

Section: Toxicity Of Plant Nitriles and Relation To Pancreatitismentioning

confidence: 99%

Xenobiotic Metabolism, Oxidant Stress and Chronic Pancreatitis

Wallig

1998

Digestion

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Chronic pancreatitis, although relatively rare in the Western World, is common in certain tropical zones where staple crops such as cassava are rich in cyanogenic glycosides. This paper reviews the evidence for a cyanide connection, with reference to experimental studies using another plant nitrile, crambene; and then examines the hypothesis that chronic pancreatitis represents a manifestation of uncoordinated detoxification reactions between pancreatic cytochrome P450 mono-oxygenases and phase II conjugating enzymes, resulting in the irreversible consumption of glutathione in the acinar cell. The conclusion is that the central role of disrupted pancreatic glutathione status, as a result of ‘xenobiotic stress’, in the evolution of chronic pancreatitis cannot be overestimated. This position contrasts with that in acute pancreatitis, in which glutathione depletion has a pivotal role too, but occurs as a result of ‘stress’ from reactive oxygen species.

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“…Zuidema (1959) first suggested that malnutrition was the cause of the adult pancreatic lesion in the group of 45 patients he studied. Severe malnutrition was, indeed, their most striking clinical feature, but Geevargheese, Pillai, and Pitchumoni (1963) found little evidence of malnutrition in the similar type of pancreatic lithiasis from South India. The malnutrition observed in adult patients with pancreatic lithiasis in Uganda and Nigeria was not an invariable feature and may have resulted from the malabsorption process instead of being an underlying cause of pancreatic disease.…”

Section: Discussionmentioning

confidence: 91%