The aetiology of gastroschisis

Curry, Joseph I.; McKinney, Patricia A.; Thornton, Jim; Stringer, Mark D.

doi:10.1111/j.1471-0528.2000.tb11645.x

Cited by 89 publications

(77 citation statements)

References 81 publications

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“…The etiology of GS has not yet been ascertained, but low socioeconomic status, poor maternal education, drug abuse, in particular with cocaine, abuse of tobacco and alcohol, and young maternal age (less than 20 years old) are associated with GS [11][12][13][14] . Although the survival rate for babies born with GS has improved and is now practically 85%, short and long-term morbidity is still a serious problem.…”

Section: Resultsmentioning

confidence: 99%

Predictive factors at birth of the severity of gastroschisis

Roessingh¹

2015

WJGP

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Section: Resultsmentioning

confidence: 99%

Predictive factors at birth of the severity of gastroschisis

Roessingh¹

2015

WJGP

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“…Several clinical papers [5][6][7][8] show that the prevalence of GS has increased signifi cantly in recent years throughout the world, i.e. by 67% in two years.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The possibility of a genetic aetiology is always present, as children from the same mother can have this problem. The most frequently observed risk factor is teenage pregnancy [7][8][9][10] .A prenatal diagnosis can be performed by measuring the alpha-fetoprotein produced by the foetal gastrointestinal tract and liver as well as foetal ultrasonography, which is considered the gold standard for diagnosis. The problem is diagnosed in the fi rst routine ultrasound performed on the mother.…”

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confidence: 99%

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Characteristics of the clinical development of a newborn with gastroschisis in an intensive care unit in latin america

Redondo¹,

Feferbaum

Vieira

et al. 2016

J. Hum. Growth Dev.

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Introduction: Congenital malformations are major diseases observed at birth. They are the second most common cause of death in the neonatal population, the fi rst one being prematurity.Objective: To characterise the clinical outcome of newborns with gastroschisis (GS) in a neonatal intensive care unit. Methods:A retrospective observational clinical study in 50 infants with GS using the association of intestinal abnormalities, impossibility of primary closure of the abdominal defect and reoperation necessity as classifi cation criteria for the disease. The signifi cance level was p < 0.05. Results:The hospitalisation to primary surgery occurred with a median age of 2 hours. Fourteen percent of children were subjected to a primary silo interposition and 24% had associated intestinal malformation. Nineteen newborns (NB) required more than one surgery. The median length of stay was 33 days, higher in patients with complex GS (56 days). All NB recovered from urine output 48 hours after surgery and 40% had hyponatraemia and oligoanuria in this period. There was no difference between the natraemia and fasting time (p = 0.79). Weight gain was similar in both groups with total parenteral nutrition and became signifi cantly higher in patients with simple GS after enteral feeding (p = 0.0046). These NB evolved 2.4 times less cholestasis. Late-onset sepsis occurred in 58% of patients and was related to the infection of the central venous catheter in 37.9% of cases. Mortality was higher in infants infected with complex GS and the overall mortality rate was 14%. Conclusion:Clinical characterisation of newborns with gastroschisis depends on the complexity and the knowledge and conduct of morbidities to reduce mortality.Key words: gastroschisis, new-born, mortality, total parenteral nutrition, renal insuffi ciency, infection. INTRODUCTIONCongenital malformations are major diseases observed at birth. In the United States, a prevalence of about 3% 1 is cited. In Brazil, a study at the Fernandez Figueira Institute in Rio de Janeiro found that the prevalence was similar, i.e. 2.7% among live newborns (NB) and 6.7% among stillbirths. Among the causes of death, neonatal malformations are the second most common reason, the fi rst one being prematurity 2 .Gastroschisis (GS) is a congenital malformation of the abdominal wall that has increased in prevalence worldwide; its causes have not been fully elucidated 3 . In the 1960s, the prevalence of this disease was 1:50,000 live births. However, Kirby et al. 4 - -Characteristics of the clinical development of a newborn with gastroschisis in an intensive care unit in latin america J Hum Growth Dev. 2016; 26(2): 190-198 DOI: http://dx.doi.org/10.7322/jhgd.119266 temporal increase of 2.23 per 10,000 live births to 4.42 per 10,000 Regarding the defi nition of live births. The current prevalence in South America is 2.9:10,000 5 . This disease is characterised by a defect in abdominal wall closure with herniation of the intestines and other abdominal organs into the amniotic cavity. ...

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“…Gastroschisis is a congenital condition with survival of greater than 90% [39], although most patients with gastroschisis have initial gut dysmotility and require parenteral nutrition. The etiology of the inherent dysmotility is likely to be a combination of exposure to amniotic fluid and constriction of the bowel at the abdominal wall defect, and much of the damage seems to occur toward the end of pregnancy [40][41][42][43][44], although there is currently no evidence that amniotic exchange improves postnatal bowel motility in humans. Delayed maturation of the intestinal pacemaker and smooth muscle cells has been demonstrated in a rat model of gastroschisis [45], which may explain the delayed onset of peristalsis in these patients.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of Dai-kenchu-to in postoperative infants with gastroschisis

Otake¹,

Uchida²,

Koike³

et al. 2012

OJPed

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Purpose: Intestinal dysfunction is a major problem after gastroschisis repair, and causes poor oral intake and poor body weight gain in infants with gastroschisis. Dai-kenchu-to (DKT) is often used in the treatment of gastrointestinal dysfunction in Japan. The purpose of this study was to analyze the effect of DKT on infants with uncomplicated gastroschisis. Methods: In this retrospective cohort study from 1991 to 2009, we assessed 16 infants with uncomplicated gastroschisis. Eight infants received 0.3 g/kg/day of DKT for 12 months (group 1) and 8 infants did not receive DKT (group 2). We analyzed their body weight as an indicator of the effect of DKT. Results: There were no significant differences in the background characteristics. The body weight of group 1 was significantly increased at the ages of 9 months (p = 0.0348) and 12 months (p = 0.0097), compared with group 2. Multivariate analyses revealed that only DKT administration had a significant impact on body weight gain at the ages of 9 months (p = 0.0201) and 12 months (p = 0.0111). No side effects related to DKT were reported. Conclusion: DKT administration might worksafely and effectively for improvingthe body weight gain in infants with uncomplicated gastroschisis.

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The aetiology of gastroschisis

Cited by 89 publications

References 81 publications

Predictive factors at birth of the severity of gastroschisis

Predictive factors at birth of the severity of gastroschisis

Characteristics of the clinical development of a newborn with gastroschisis in an intensive care unit in latin america

Safety and efficacy of Dai-kenchu-to in postoperative infants with gastroschisis

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