Background: Choledochoduodenal fistula is an abnormal
tract between the common bile duct and the duodenum.
Common etiology includes iatrogenic instrumentation,
choledocholithiasis, and duodenal ulcer. In rare cases,
the fistula is a complication secondary to an occult malignancy
such as biliary adenocarcinoma. Here we report
a case with adenosquamous carcinoma of the common
bile duct that causes a choledochoduodenal fistula. Case
Report: A 72-year-old female patient presented with epigastralgia
and poor appetite for 3 months. Upper gastrointestinal
endoscopy showed an orifice with bile leakage
in the posterior wall of the second portion of the
duodenum. A biliodigestive fistula was noted. Endoscopic
retrograde cholangiopancreatography (ERCP) showed
a choledochoduodenal fistula and a contrast filling defect
in the distal common bile duct. Endoscopic
transpapillary biopsy of the distal common bile duct revealed
poorly differentiated adenocarcinoma. Pancreatoduodenectomy
was performed by laparotomy. Pathological
assessment revealed a moderately differentiated
adenosquamous carcinoma of distal common bile duct.
The patient’s postoperative period was uneventful. Conclusion:
For clinical evaluation of choledochoduodenal
fistula of unknown etiology and if occult malignancy is
suspected upper gastrointestinal endoscopy and ERCP
should be done. Surgical resection is mandatory in
choledochoduodenal fistulas with biliary cancer origin.