The aetiology and management of atrophic rhinitis

Dutt, Sunil; Kameswaran, Mohan

doi:10.1258/002221505774783377

Cited by 83 publications

(101 citation statements)

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“…1 Numerous theories have been proposed to account for the pathogenesis of this condition. 1,2 Although fungal rhinosinusitis has gained much attention in recent years, the role of fungi in the pathogenesis of primary atrophic rhinitis is scarcely documented in the literature. A search of the PubMed/Medline database failed to identify fungal studies in this condition in humans.…”

Section: Introductionmentioning

confidence: 99%

Microbiological study of role of fungi in primary atrophic rhinitis

Effat

Madany

2008

J. Laryngol. Otol.

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Background: Fungal rhinosinusitis has gained much attention in recent years. To our knowledge, no previous studies have addressed the role of fungus in primary atrophic rhinitis.Study design: Prospective case study. Patients and methods: All cases of primary atrophic rhinitis presenting to the out-patient department at El-Sahel Teaching Hospital over a five-month period were included in the study. Crusts and purulent secretions removed from patients' nasal cavities underwent microbiological analysis at the Medical Microbiology and Immunology department of the Cairo University Faculty of Medicine. Special emphasis was placed on fungal isolation.Results: Fourteen consecutive cases of primary atrophic rhinitis were studied in the five-month period starting 26 November 2007. Patients comprised eight females and six males, with an age range of 12 to 65 years (mean 37 years). Microscopy of the crusts and purulent secretions showed pus cells in most of the samples. Klebsiella species were isolated from nine patients (65 per cent), and other bacterial species were isolated in most of the remainder. Fungal elements, most commonly aspergillus species, were isolated in 13 patients (93 per cent).Conclusion: It is proposed that the initial trigger for primary atrophic rhinitis is a virulent bacterial infection of the nasal lining, which leads to damage of the ciliated epithelium. This initiates the cascade of events leading to inflammation of the mucosa and submucosa, with secondary pyogenic osteomyelitis of the turbinate bone. The persistence of purulent secretion, within the setting of impaired mucociliary clearance, leads to saprophytic fungal colonisation which contributes greatly to the clinical picture.

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Section: Introductionmentioning

confidence: 99%

Microbiological study of role of fungi in primary atrophic rhinitis

Effat

Madany

2008

J. Laryngol. Otol.

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“…1 The etiology of chronic rhinitis is still controvertible and its etiopathogenesis is explained by few theories. 2 Atrophic rhinitis is a common condition in tropical countries like India China etc., but significant decline in the incidence was observed in North America, some parts of Europe.…”

Section: Introductionmentioning

confidence: 99%

Primary and secondary atrophic rhinitis: a microbiological and histopathological study

Parameshwar

Noel

2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Atrophic rhinitis is a distressing chronic nasal pathology characterized by progressive nasal mucosal atrophy, formation of thick crusts and a distinct foul odor. The etiology of this condition is still controvertible. The present study was undertaken to evaluate the microbiological flora and histopathological changes in primary and secondary atrophic rhinitis patients.Methods: A total 50 atrophic rhinitis patients (15 males & 35 females) were considered, all patients were undergone for complete haemogram, microbiological examination of nasal pus and histopathological examination for biopsied material. Results: A total 82% patients were shown primary atrophic rhinitis and 18% cases were secondary atrophic rhinitis. Pseudomonas aeruginosa was commonly isolated bacteria in 72%, followed by Staphylococcus aureus (12%) and other bacteria were E. coli (8%) and Proteus mirabilus (6%) and sterile swab in 2% cases. Squamous metaplasia was found in 78% cases, while transitional metaplasia in 16% cases. The incidence of dilated blood vessels, endarteritis, and periarteritis in lamina propria is 44%, 30% and 16% respectively.Conclusions: Pseudomonas aeruginosa was most commonly isolated bacteria. The most important pathological change is squamous cell metaplasia in atrophic rhinitis patients.

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“…Bu durum, konkal kemikte sekonder piyojenik osteomiyelit ile mukoza ve submukozada iltihaba yol açan olaylar zincirini başlatır. Bozulmuş nazal mukosiliyer temizlenme ortamının saprofitik K. ozaenae kolonizasyonuna neden olarak klinik tabloya büyük katkı sağladığı düşünülmektedir (2,5,6 …”

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