The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma

Silkoff, Philip E.; Carlson, Mats; Bourke, Trevor; Katial, Rohit; Ögren, Elisabeth; Szefler, Stanley J.

doi:10.1016/j.jaci.2004.08.042

Cited by 145 publications

(96 citation statements)

References 107 publications

(119 reference statements)

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“…12,44 In fact, the FDA approved the use of FeNO in individuals with asthma to monitor response to anti-inflammatory agents. 44 The results of the present study confirm that FeNO may be a valuable biomarker of response to inhaled anti-inflammatory therapy in children with asthma.…”

Section: Discussionmentioning

confidence: 99%

Seasonal variation and environmental predictors of exhaled nitric oxide in children with asthma

Spanier

Hornung

Kahn

et al. 2008

Pediatric Pulmonology

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SummaryThe fraction of exhaled nitric oxide (FeNO), a measure of airway inflammation, shows promise as a noninvasive tool to guide asthma management, but there is a paucity of longitudinal data about seasonal variation and environmental predictors of FeNO in children. The objective of this project was to evaluate how environmental factors affect FeNO concentrations over a 12-month study period among children with doctor diagnosed asthma. We conducted a prospective cohort study of 225 tobacco-smoke exposed children age 6 to 12 years with doctor-diagnosed asthma including measures of FeNO, medication use, settled indoor allergens (dust mite, cat, dog, and cockroach), and tobacco smoke exposure. Baseline geometric mean FeNO was 12.4 ppb (range 1.9 to 60.9 ppb). In multivariable analyses, higher baseline FeNO levels, atopy, and fall season were associated with increased FeNO levels, measured 6 and 12 months after study initiation, whereas inhaled steroid use, summer season, and increasing nicotine exposure were associated with lower FeNO levels. In secondary analyses of allergen sensitization, only sensitization to dust mite and cat were associated with increased FeNO levels. Our data demonstrate that FeNO levels over a year long period reflected baseline FeNO levels, allergen sensitization, season, and inhaled steroid use in children with asthma. These results indicate that FeNO levels are responsive to common environmental triggers as well as therapy for asthma in children. Clinicians and researchers may need to consider an individual's baseline FeNO levels to manage children with asthma.

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Section: Discussionmentioning

confidence: 99%

Seasonal variation and environmental predictors of exhaled nitric oxide in children with asthma

Spanier

Hornung

Kahn

et al. 2008

Pediatric Pulmonology

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“…11 Normal ranges of FeNO level were considered to be from 4 to 25 ppb. After respiratory evaluation with spirometry, an asthma control test (ACT) and blood sampling were performed.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Orally Exhaled Nitric Oxide in Allergic versus Nonallergic Rhinitis

2012

Am J Rhinol�Allergy

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“…[10] With NIOX the corresponding spesifications are the following: lowest detection limit 2 ppb and accuracy ± 2.5 ppb of measured value < 50 ppb and ± 5% of the measured value > 50 ppb. [11] The study was approved by institutional pediatrics ethics committee of Helsinki University Central Hospital, and informed concent was obtained from the parent of each child participating in the study study children. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 …”

Section: Conflict Of Interestmentioning

confidence: 99%

Can we use portable nitric oxide analyzer in young children?

Kalliola

Malmberg

Rito

et al. 2011

Pediatric Pulmonology

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ObjectiveManagement of asthma could be improved by measuring exhaled nitric oxide (FENO). Portable hand‐held FENO analyzer (NIOX MINO) is practical and small and could be used also in the primary care office. It has demonstrated good repeatability and correlation with stationary device (NIOX) in adults and school aged children, but so far there have been no reports on young children. The aim of this study was to compare conventional chemiluminescence device (NIOX) with a hand‐held electrochemical device (NIOX MINO) in young children.DesignPaired measurements of FENO were performed with the stationary chemiluminescence‐based analyzer (NIOX) and with portable electrochemical device (NIOX MINO) in children with asthmatic symptoms and age‐matched controls.ResultsFifty‐five children with mean (range) age of 5.7 (3.9–8.5) years were evaluated with both devices. Measurements were successful with both devices in 40 out of 57 children. NIOX MINO was more difficult to use than NIOX in this age group, success rates being 73% and 93%, respectively (P = 0.004). The reproducibility was similar and there was a close correlation between FENO measured by the two devices (r = 0.97, P < 0.001). However, Bland–Altman plot demonstrated limits of agreement that were relatively wide compared to low levels of FENO in the sample. Both devices were sensitive enough to distinguish higher FENO levels in children with asthmatic symptoms, compared to healthy controls.ConclusionsWe conclude that NIOX MINO can be used as a screening tool for the assessment of airway inflammation in children from the age of 4 years, but its applicability is limited by lower measurement success rate and relatively poor accuracy and detection limit at low levels of FENO. Pediatr Pulmonol. 2011; 46:627–631. © 2011 Wiley‐Liss, Inc.

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The Aerocrine exhaled nitric oxide monitoring system NIOX is cleared by the US Food and Drug Administration for monitoring therapy in asthma

Cited by 145 publications

References 107 publications

Seasonal variation and environmental predictors of exhaled nitric oxide in children with asthma

Seasonal variation and environmental predictors of exhaled nitric oxide in children with asthma

Comparison of Orally Exhaled Nitric Oxide in Allergic versus Nonallergic Rhinitis

Can we use portable nitric oxide analyzer in young children?

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