The adverse prognostic effect of tumor budding on the evolution of cutaneous head and neck squamous cell carcinoma

Gonzalez-Guerrero, Miriam; Martínez–Camblor, Pablo; Vivanco, Blanca; Fernández‐Vega, Iván; Munguía-Calzada, Pablo; Gonzalez-Gutierrez, Maria Paz; Rodrigo, Juan P.; Galache, Cristina; Santos‐Juanes, Jorge

doi:10.1016/j.jaad.2017.01.015

Cited by 34 publications

(46 citation statements)

References 17 publications

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“…2,8,9,11,12,20,27,34,40,45,48,54 This definition is in accordance with the recent recommendation by the International Tumor Budding Consensus Conference (ITBCC 2016) in colorectal cancer, 55 and also agrees with studies on other cancers. 2,8,9,11,12,20,27,34,40,45,48,54 This definition is in accordance with the recent recommendation by the International Tumor Budding Consensus Conference (ITBCC 2016) in colorectal cancer, 55 and also agrees with studies on other cancers.…”

Section: Evaluation Of Tumor Buddingsupporting

confidence: 87%

“…2,12,37,54,59 High reproducibility has also been shown in many studies evaluating tumor budding in other cancers. In studies of tumor budding in HNSCC, good to excellent intraobserver and interobserver reproducibility has been widely reported.…”

Section: Evaluation Of Tumor Buddingmentioning

confidence: 79%

“…More recent studies have confirmed the prognostic value of tumor budding in laryngeal cancer. 12 Moreover, in recent reports on early stage of oral cancers, Sakata et al 31 and Shimizu et al 30 found that tumor budding being a reliable prognostic marker for nodal metastasis. Similar results on the significance of tumor budding were reported in an independent cohort of hypopharyngeal SCC by Imai et al, 11 and also for pharyngeal SCC by Karpathiou et al 34 Specifically, identification of high intensity of tumor budding in HNSCC has been associated with metastasis to cervical lymph nodes.…”

Section: Tumor Budding As a Simple Promising Prognostic Marker In Hmentioning

confidence: 98%

“…56,57 Of note, a recent study has reported an excellent reproducibility and reliability of ITBCC 2016 scoring method in oral tongue cancer. 2,11,12,27,31,40,45,48,54,58 A method of 10 HPFs (where average score is considered) was recently applied by Boxberg et al 49 and this showed significant prognostic value in OSCC. 2,11,12,27,31,40,45,48,54,58 A method of 10 HPFs (where average score is considered) was recently applied by Boxberg et al 49 and this showed significant prognostic value in OSCC.…”

Section: Evaluation Of Tumor Buddingmentioning

confidence: 99%

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Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

et al. 2019

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Invasion and metastasis are hallmarks of cancer. The concept of tumor budding at tumor‐host interface has been documented in many carcinomas. A growing body of evidence indicates that tumor budding is a sign of invasion and early step for metastasis of many epithelial cancers including head and neck squamous cell carcinoma (HNSCC). In addition, recent research has underlined the importance of tumor budding as a promising prognosticator in HNSCC. This review summarizes the findings regarding tumor budding in HNSCC and focuses on the role of tumor budding in invasion and metastasis. Also, we highlight the prognostic significance of tumor budding in HNSCC and its potential for improving clinical decision making in terms of recommending optimal individualized treatment for this patient population.

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Section: Evaluation Of Tumor Buddingsupporting

confidence: 87%

Section: Evaluation Of Tumor Buddingmentioning

confidence: 79%

Section: Tumor Budding As a Simple Promising Prognostic Marker In Hmentioning

confidence: 98%

Section: Evaluation Of Tumor Buddingmentioning

confidence: 99%

See 2 more Smart Citations

Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

et al. 2019

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“…Tumor budding is defined as the presence of either isolated single cells or small cell clusters (≤4) scattered in the stroma ahead of the invasive tumor front. The intensity of tumor budding (budding index) was classified as low (<5 buds) or high (≥5 buds) …”

Section: Methodsmentioning

confidence: 99%

Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

et al. 2018

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Background Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC). Objective To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients. Methods FAK and cortactin expression was analyzed by immunohistochemistry on paraffin‐embedded tissue samples from 100 patients with cSCC, and correlated with the clinical data. Results FAK overexpression was a significant risk factor for nodal metastasis with crude and adjusted ratios (HRs) of 2.04, (95% CI [1.08‐3.86], [P = 0.029]) and 2.23 (95% CI [1.01‐4.91], [P = 0.047]), respectively. Cortactin expression was not a significant risk factor for nodal metastasis. Conclusion These findings demonstrate that FAK overexpression is an independent predictor of nodal metastasis that might be helpful for risk stratification and management of patients with cSCC.

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Association of Patient Risk Factors, Tumor Characteristics, and Treatment Modality With Poor Outcomes in Primary Cutaneous Squamous Cell Carcinoma

et al. 2023

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ImportancePrimary cutaneous squamous cell carcinoma is usually curable; however, a subset of patients develops poor outcomes, including local recurrence, nodal metastasis, distant metastasis, and disease-specific death.ObjectivesTo evaluate all evidence-based reports of patient risk factors and tumor characteristics associated with poor outcomes in primary cutaneous squamous cell carcinoma and to identify treatment modalities that minimize poor outcomes.Data SourcesPubMed, Embase, and SCOPUS databases were searched for studies of the topic in humans, published in the English language, from database inception through February 8, 2022.Study SelectionTwo authors independently screened the identified articles and included those that were original research with a sample size of 10 patients or more and that assessed risk factors and/or treatment modalities associated with poor outcomes among patients with primary cutaneous squamous cell carcinoma.Data Extraction and SynthesisData extraction was performed by a single author, per international guidelines. The search terms, study objectives, and protocol methods were defined before study initiation. A total of 310 studies were included for full-text assessment. Owing to heterogeneity of the included studies, a random-effects model was used. Data analyses were performed from May 25 to September 15, 2022.Main Outcomes and MeasuresFor studies of risk factors, risk ratios and incidence proportions; and for treatment studies, incidence proportions.ResultsIn all, 129 studies and a total of 137 449 patients with primary cutaneous squamous cell carcinoma and 126 553 tumors were included in the meta-analysis. Several patient risk factors and tumor characteristics were associated with local recurrence, nodal metastasis, distant metastasis, disease-specific death, and all-cause death were identified. Among all factors reported by more than 1 study, the highest risks for local recurrence and disease-specific death were associated with tumor invasion beyond subcutaneous fat (risk ratio, 9.1 [95% CI, 2.8-29.2] and 10.4 [95% CI, 3.0- 36.3], respectively), and the highest risk of any metastasis was associated with perineural invasion (risk ratio, 5.0; 95% CI, 2.3-11.1). Patients who received Mohs micrographic surgery had the lowest incidence of nearly all poor outcomes; however, in some results, the 95% CIs overlapped with those of other treatment modalities.Conclusions and RelevanceThis meta-analysis identified the prognostic value of several risk factors and the effectiveness of the available treatment modalities. These findings carry important implications for the prognostication, workup, treatment, and follow-up of patients with primary cutaneous squamous cell carcinoma.Trial RegistrationPROSPERO Identifier: CRD42022311250

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The adverse prognostic effect of tumor budding on the evolution of cutaneous head and neck squamous cell carcinoma

Cited by 34 publications

References 17 publications

Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

Association of Patient Risk Factors, Tumor Characteristics, and Treatment Modality With Poor Outcomes in Primary Cutaneous Squamous Cell Carcinoma

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