The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos/larvae

Li, Ruiwen; Wang, Hengqi; Mi, Chuang; Feng, Chenglian; Yang, Lihua; Zhou, Bingsheng

doi:10.1016/j.chemosphere.2018.12.198

Cited by 94 publications

(24 citation statements)

References 41 publications

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“…Taken together, these suggest that disruption of neurodevelopment was a common mechanism of action for FRC-induced toxicity (Figure 3C). This was consistent with studies showing that BDE-47, chlorinated FRCs such as TCEP, TCPP and aryl FRCs such as TPP disrupted neurodevelopmental genes (Shi et al, 2018;Chen et al, 2019;Li et al, 2019). Interestingly, genetic signatures showed that neurotransmitter synthesis and activity were disrupted across several FRC classes, with the exception of chlorinated phosphates.…”

Section: Neurotoxicity Of Frcssupporting

confidence: 89%

Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks

Dasgupta

Dunham

Truong

et al. 2021

Front. Cell Dev. Biol.

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The ubiquitous use of flame retardant chemicals (FRCs) in the manufacture of many consumer products leads to inevitable environmental releases and human exposures. Studying toxic effects of FRCs as a group is challenging since they widely differ in physicochemical properties. We previously used zebrafish as a model to screen 61 representative FRCs and showed that many induced behavioral and teratogenic effects, with aryl phosphates identified as the most active. In this study, we selected 10 FRCs belonging to diverse physicochemical classes and zebrafish toxicity profiles to identify the gene expression responses following exposures. For each FRC, we executed paired mRNA-micro-RNA (miR) sequencing, which enabled us to study mRNA expression patterns and investigate the role of miRs as posttranscriptional regulators of gene expression. We found widespread disruption of mRNA and miR expression across several FRCs. Neurodevelopment was a key disrupted biological process across multiple FRCs and was corroborated by behavioral deficits. Several mRNAs (e.g., osbpl2a) and miRs (e.g., mir-125b-5p), showed differential expression common to multiple FRCs (10 and 7 respectively). These common miRs were also predicted to regulate a network of differentially expressed genes with diverse functions, including apoptosis, neurodevelopment, lipid regulation and inflammation. Commonly disrupted transcription factors (TFs) such as retinoic acid receptor, retinoid X receptor, and vitamin D regulator were predicted to regulate a wide network of differentially expressed mRNAs across a majority of the FRCs. Many of the differential mRNA-TF and mRNA-miR pairs were predicted to play important roles in development as well as cancer signaling. Specific comparisons between TBBPA and its derivative TBBPA-DBPE showed contrasting gene expression patterns that corroborated with their phenotypic profiles. The newer generation FRCs such as IPP and TCEP produced distinct gene expression changes compared to the legacy FRC BDE-47. Our study is the first to establish a mRNA-miR-TF regulatory network across a large group of structurally diverse FRCs and diverse phenotypic responses. The purpose was to discover common and unique biological targets that will help us understand mechanisms of action for these important chemicals and establish this approach as an important tool for better understanding toxic effects of environmental contaminants.

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Section: Neurotoxicity Of Frcssupporting

confidence: 89%

Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks

Dasgupta

Dunham

Truong

et al. 2021

Front. Cell Dev. Biol.

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“…In some cases, "modified structure of chorda" [69], "body shape" [69], "notochord anomalies", "tail anomalies", and "kinks (wavy, curled, bend)" were employed to describe spinal cord malformations without further distinction [83]. No further publications could be found, directly discussing the different curvatures observed in zebrafish embryos, although-according to the present study-spinal curvature is a group of endpoints quite frequently observed (Table 2); with the literature providing the further examples [55,[84][85][86][87][88][89][90].…”

Section: Sublethal Morphological Alterations In Zebrafish Embryos Witmentioning

confidence: 86%

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

et al. 2020

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Background The Fish Embryo Acute Toxicity (FET) test with the zebrafish (Danio rerio) embryo, the OECD test guideline (TG) 236, has been designed as an alternative for acute fish toxicity testing such as the OECD Acute Fish Toxicity Test (TG 203). To provide equivalent sensitivity to the acute fish test, the original FET test was designed to use only four morphological core endpoints: coagulation of the embryo, lack of somite formation, lack of heart beat, and non-detachment of the tail. These endpoints were selected due to (1) their association with mortality, directly or indirectly, (2) improve the practicality for screening by well-trained technical staff, and (3) the endpoints being relatively simple morphological alterations. Results With the growing need to understand the developmental toxicity of compounds found in the environment, the FET protocol has repeatedly been extended to a multitude of additional morphological endpoints that also allow the monitoring of teratogenicity. As the extensive use of the FET test has generated a multitude of observations in the scientific literature, a harmonisation of the terminology used for the description of the morphological effects seen after chemical exposure has become necessary. Conclusion For this end, the present communication provides an overview of both common and selected more specific morphological effects seen in zebrafish embryos after exposure to a wide variety of chemical substances together with suggestions for a harmonised nomenclature.

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“…could play some part in the malformation. [ 12 ] Moreover, it would be important to compare the results on zebrafish to other aquatic organisms such as Daphnia to arrive a broader sense of the implications of nano‐photocatalysts exposure with light irradiation. [ 13 ]…”

Section: Figurementioning

confidence: 99%

Environmental Hazard Potential of Nano‐Photocatalysts Determined by Nano‐Bio Interactions and Exposure Conditions

Peng

Jiang

et al. 2020

Small

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Nano‐photocatalysts are known for their ability to degrade pollutants or perform water splitting catalyzed by light. Being the key functional ingredients of current and future products, the potential of nano‐photocatalysts releasing into the environment and causing unintended harm to living organisms warrants investigation. Risk assessment of these materials serves as an important step to allow safe implementation and to avoid irrational fear. Using TiO2 and g‐C3N4 as representative nano‐photocatalysts, this study evaluates their hazard potential in zebrafish. Under simulated solar light, nano‐photocatalysts up to 100 mg L−1 show no acute toxicity to zebrafish embryos due to the protection of chorions. The short‐lived reactive oxygen species generated by nano‐photocatalysts only exert injury to the hatched larvae at and above 50 mg L−1. The input of solar energy, determined by the depth of water, irradiation time, and light intensity, greatly influences the toxicity outcome. Increasing concentrations of natural organic matters contribute positively to the hazard potential at 0–10 mg L−1 while gradually diminishing the hazardous effect above 10 mg L−1. This study demonstrates the importance of nano‐bio interactions and environmental exposure conditions in determining the safety profile of nano‐photocatalysts.

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The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos/larvae

Cited by 94 publications

References 41 publications

Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks

Phenotypically Anchored mRNA and miRNA Expression Profiling in Zebrafish Reveals Flame Retardant Chemical Toxicity Networks

Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

Environmental Hazard Potential of Nano‐Photocatalysts Determined by Nano‐Bio Interactions and Exposure Conditions

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