The Adverse Effect Dilemma: Quest for Accessible Information

Roush, Maura K.; McNutt, Robert A.; Gray, Tracy

doi:10.7326/0003-4819-114-4-298

Cited by 24 publications

(14 citation statements)

References 3 publications

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“…1). 6–24 The majority of the methodological evaluations (11/19) included more than one search for adverse effect data (Table 2). 6,8–10,13,16,19,21–24 Ninety‐four separate searches were conducted for information on adverse effects, however, four methodological evaluations (representing 36 searches) did not present the results of each search separately 8–10,24 .…”

Section: Resultsmentioning

confidence: 99%

“…Types of interventions. Most of the methodological evaluations (16/19, 84%) included searches for named drug interventions 6–14,16–18,20–23 . Three methodological evaluations searched for natural products, such as herbal medicines 15,24 or aromatherapy 19 and one methodological evaluation included a search on tooth extraction (in addition to searches for a drug intervention) 23 …”

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confidence: 99%

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Sources of information on adverse effects: a systematic review

Golder

Loke

2010

Health Info Libraries J

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Background: Systematic reviews can provide accurate and timely information on adverse effects. An essential part of the systematic review process is a thorough search of the literature. This often requires searching many different sources. However, it is unclear which sources are most effective at providing information on adverse effects. Objective: To identify and summarise studies that have evaluated sources of information on adverse effects. Methods: Studies were located by searching in 10 databases as well as by reference checking, hand searching, citation searching and contacting experts. Results: A total of 6218 citations were retrieved yielding 19 studies which met the inclusion criteria. The included studies tended to focus on the adverse effects of drug interventions and compare the relative value of different sources using the number of relevant references retrieved from searches of each source. However, few studies were conducted recently with a large sample of references. Conclusions: This review suggests that EMBASE, Derwent Drug File, MEDLINE and industry submissions may potentially provide the greatest number of relevant references for information on adverse effects of drugs. However, a systematic evaluation of the current value of different sources of information for adverse effects is urgently required.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Sources of information on adverse effects: a systematic review

Golder

Loke

2010

Health Info Libraries J

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“…There has been a growing number of reported cases of acute pancreatitis associated with the use of enalapril [2,3], lisinopril [4,5], and captopril [5]. Also, the number of cases of pancreatitis owing to various ACE inhibitors reported to the Food and Drug Administration and various pharmaceutical companies totals over 100 [5].…”

Section: Angio-oedema Induced By Ace Inhibitorsmentioning

confidence: 99%

“…The pathogenesis of polymyositis in HTLV-Iinfected patients is not clearly known and seems to be related to an immunological process and\or direct infection of the muscle fibres by virus [2,3]. The clinical history of this patient suggests that in polymyositis associated with HTLV-I infection, the prognosis should not be very different from the other idiopathic polymyositis.…”

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confidence: 99%

Angio‐oedema induced by ACE inhibitors

Marinella

1996

Journal of Internal Medicine

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“…Preliminary studies indicate five key approaches. Firstly, searches can be restricted to using either text words or indexing terms for specified adverse effects, such as, nausea 19−21 . This approach, however, is only useful if the adverse effects under consideration are already known.…”

Section: Introductionmentioning

confidence: 99%

Developing efficient search strategies to identify reports of adverse effects in medline and embase

Golder

McIntosh

Duffy

et al. 2006

Health Info Libraries J

108

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Objective: This study aimed to assess the performance, in terms of sensitivity and precision, of different approaches to searching  and  to identify studies of adverse effects. Methods: Five approaches to searching for adverse effects evidence were identified: approach 1, using specified adverse effects; approach 2, using subheadings/qualifiers; approach 3, using text words; approach 4, using indexing terms; approach 5, searching for specific study designs. The sensitivity and precision of these five approaches, and combinations of these approaches, were compared in a case study using a systematic review of the adverse effects of seven anti-epileptic drugs. Results: The most sensitive search strategy in  (97.0%) required a combination of terms for specified adverse effects, floating subheadings, and text words for 'adverse effects'. In , a combination of terms for specified adverse effects and text words for 'adverse effects' provided the most sensitive search strategy (98.6%). Both these search strategies yielded low precision (2.8%). Conclusions: A highly sensitive search in either database requires a combination of approaches, and has low precision. This suggests that better reporting and indexing of adverse effects is required and that an effective generic search filter may not yet be feasible.

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The Adverse Effect Dilemma: Quest for Accessible Information

Cited by 24 publications

References 3 publications

Sources of information on adverse effects: a systematic review

Sources of information on adverse effects: a systematic review

Angio‐oedema induced by ACE inhibitors

Developing efficient search strategies to identify reports of adverse effects in medline and embase

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