The Advent of High-Throughput Sequencing Studies of Chronic Obstructive Pulmonary Disease

Ortega, Victor E.; Celedón, Juan C.

doi:10.1164/rccm.201601-0074ed

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Genetic Predisposition1

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2017

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“…Although novel because it targeted COPD using whole-exome sequencing, this study found only trends of association which were non-significant. This might indicate the need for larger studies better powered to detect rare variants, but which might also be capable of investigating interactions between genes and smoking (56). It is also possible, as the authors point out that susceptibility to COPD is determined by multiple rather than just a few gene (57).…”

Section: Genetic Predispositionmentioning

confidence: 99%