The Advantages of^99mTc DTPA(Sn) in Dynamic Renal Scintigraphy and Measurement of Renal Function

Abstract

The results of excretion urography (IVU) and dynamic renal scintigraphy using 99mTc DTPA(Sn) were compared in 109 urological patients. Computer analysis of the gamma camera data provided a reproducible, accurate, qualitative and quantitative assessment of renal function and was found to be superior to urography in the detection of morphological defects of the renal parenchyma and in the identification of early upper tract obstruction. The radio-isotope study is a safe, non-invasive investigation, easily performed on an out-patient basis, requires no prior preparation and is without significant radiation hazard to the patient.

The Influence of Renal Prostaglandins on Glomerular Filtration Rate (GFR) and Calcium Excretion in Urolithiasis

“…Further support for a focal rather than a generalised stimulus to increased glomerular filtration derived from our experience of the dynamic scintigram in renal stone formers. Our attention was drawn to the consistency of localised areas of increased isotope density corresponding to the site of the stone, a previous stone, or nephrocalcinosis, which were initially interpreted as areas of stasis or obstruction (Buck et al, 1980). However, with improved techniques of selective renography these arcas were found in many instances, to represent areas of enhanced localised functional activity and clearance in the renal parenchyma and not obstruction.…”

Radiological Investigations, Biochemical Renal Function Tests and the Changes After Surgery in Renal Calculus Obstructive Uropathy

“…The simple and non-invasive nature of the procedure has an added advantage and is used widely now-a-days. 5 It is emphasized that stone analysis should be performed in all first-time stone formers. 6 Nonsteroidal Antiinflammatory Drugs (NSAIDs) are the drug of choice in cases of renal colic.…”

99mTechnetium DMSA and the Prediction of Recovery in Obstructive Uropathy

“…Obstruction in the urinary tract is still primarily diagnosed by a well-performed excretion urogram in most cases. To supplement this, and in special situations, isotope renography using DTPA or Hippuran with modifications such as induced 'diuresis (O'Reilly et al, 1978) or deconvolution analysis (Britton el al., 1979;Buck et al, 1980) may be useful, as are pressure flow studies in equivocal cases (Whitaker, 1976).…”