The advantage of establishing homogeneous patient groups: Is it worth isolating ‘juvenile acne of the face’?

Abstract

The next step in our work will be to elaborate severity scales which are dedicated to a single type of acne.

Microcomedones in non‐lesional acne prone skin New orientations on comedogenesis and its prevention

“…Data on prescription medicines taken before and during SMFE treatments are shown in Table (See Supplementary Material). According to current views and criteria, we analysed juvenile and adult acne separately in order to follow homogeneous groups of patients.…”

“…We conducted an observational clinical follow‐up of patients with acne ( N = 23) for at least 48 weeks with a protocol aimed at complementing the treatment recommended by current acne therapeutic guidelines with a skin‐care preparation identified for its comedolytic properties (See Appendix and Table ). Patients were analysed in two groups (‘juvenile’ and ‘adult’) as recommended by Revuz et al . The study met the ethical guidelines of the Declaration of Helsinki with written informed consent and was accepted by the Geneva Ethic Committee for Human Research.…”

“…Sebocytes were exposed to 300 lg/mL SMFE for three consecutive days, and then, a transcriptomic analysis was performed using RNA-Seq. According to current views and criteria, 20 we analysed juvenile and adult acne separately in order to follow homogeneous groups of patients. Sebocyte cultures were exposed to 60 lg/mL SMFE for 48 h, then 1 nmol/L TCDD was applied for 24 h. Twenty-four hours later, CYP1A1 enzymatic activity was analysed by EROD, and CYP1A1 mRNA was analysed by qPCR.…”

Development and evaluation of a Global Acne Severity Scale (GEA Scale) suitable for France and Europe

“…Revuz et al. have defined the characteristics of juvenile facial acne, which is characterized by four factors: presence of comedones, age, facial location and lack of any external causative factor 23 …”

“…Revuz et al have defined the characteristics of juvenile facial acne, which is characterized by four factors: presence of comedones, age, facial location and lack of any external causative factor. 23 Another important point concerning the grading of acne lesions is the training. Training is necessary to improve the reproducibility of lesion counting and has also been shown to improve results with a global scale.…”