The advanced glaucoma intervention study (AGIS)*113. Comparison of treatment outcomes within race: 10-year results

Ederer, Fred; Gaasterland, D.E.; Dally, Leonard G.; Kim, Jonghyeon; VanVeldhuisen, Paul; Blackwell, Beth; Prum, Bruce E.; Shafranov, George; Allen, Robert C.; Beck, Allen D.; Investigators, Agis

doi:10.1016/j.ophtha.2003.09.025

Cited by 179 publications

(39 citation statements)

References 44 publications

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“…In a long term treatment study of African American and Caucasian patients with pharmacologically uncontrolled glaucoma, African Americans experienced better visual outcomes when argon laser trabeculoplasty (ALT) was performed prior to a two-step trabeculectomy procedure. This is in contrast to Caucasians who experienced better control of IOP when ALT was performed “between” the two rounds of trabeculectomy (26). This potentially supports biological differences between the groups.…”

Section: Genetic Epidemiology Of Poagmentioning

confidence: 78%

Primary Open-Angle Glaucoma Genetics in African Americans

Restrepo

Bailey

2017

Curr Genet Med Rep

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Purpose of review Individuals of African descent are at highest risk for developing primary open-angle glaucoma (POAG), a devastating disease and major contributor of blindness worldwide. Currently, there is a large dearth of knowledge in this area despite a critical need for better understanding the underlying genetic and environmental factors afflicting this population. Here we highlight the current literature exploring the genetics of POAG in African Americans. Recent findings Current studies have yet to replicate European POAG index variants (i.e. CDKN2B-AS1 and SIX1/SIX6) in African Americans or to definitely exclude that these loci contribute to risk in African descent populations. Recent studies have evaluated clinical features that may account for some differences in POAG risk between African Americans and European Americans. Summary In summary, little headway has been made in elucidating the genetics of primary open-angle glaucoma in African Americans and other individuals of African descent.

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Section: Genetic Epidemiology Of Poagmentioning

confidence: 78%

Primary Open-Angle Glaucoma Genetics in African Americans

Restrepo

Bailey

2017

Curr Genet Med Rep

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“…3435 This can be justified by the greater fibrovascular proliferation and a more intense healing process in these eyes, even when using antiproliferative agents in the intraoperative period. 36 A retrospective case-control study compared the performance of the AGV in 86 eyes of Caucasians (n = 43) and African-Americans followed for 2.3 and 2.5 years respectively.…”

Section: Discussionmentioning

confidence: 99%

Intraocular Pressure Control after Implantation of an Ahmed Glaucoma Valve in Eyes with a Failed Trabeculectomy

Schimiti¹,

Abe

Tavares

et al. 2016

Journal of Current Glaucoma Practice

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AimTo evaluate the results of Ahmed glaucoma valve (AGV) in eyes with a failed trabeculectomy.Materials and methodsThis retrospective study evaluated 61 eyes with a failed trabeculectomy that underwent implantation of an AGV due to uncontrolled intraocular pressure (IOP) on maximal medical therapy. Success was defined as IOP ≤ 21 mm Hg (criterion 1) or 20% reduction in IOP (criterion 2) with or without antiglaucoma medications. Persistent hypotony, loss of light perception, and reoperation for IOP control were defined as failure.ResultsMean preoperative IOP and mean lOPs at 6, 12, and 24 months were 21.93 ± 6.32 mm Hg (n = 61), 14.15 ± 4.33 mm Hg (n = 59), 13.21 ± 4.44 mm Hg (n = 56), and 13.60 ± 3.27 mm Hg (n = 25) respectively. Mean number of antiglaucoma medications preoperatively and at 6, 12, and 24 months was 3.95 ± 0.85, 2.19 ± 1.38, 2.48 ± 1.44, and 2.40 ± 1.32 respectively. The reductions in the number of medications and IOP measurements were statistically significant at all time intervals (p < 0.001, Wilcoxon signed rank test). According to criterion 1, the Kaplan-Meier survival curve disclosed success rates of 75% at 12 and 24 months. According to criterion 2, the success rates were 57% at 12 months and 55% at 24 months. The most frequent complications were hypertensive phase (18%) and shallow anterior chamber (16.4%).ConclusionThe AGV may effectively reduce IOP in eyes that had a failed trabeculectomy.Clinical significanceThe AGV is an alternative in eyes with a failed trabeculectomy.How to cite this articleSchimiti RB, Abe RY, Tavares CM, Vasconcellos JPC, Costa VP. Intraocular Pressure Control after Implantation of an Ahmed Glaucoma Valve in Eyes with a Failed Trabeculectomy. J Curr Glaucoma Pract 2016;10(3):97-103.

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“…While experimental models of glaucoma in which IOP elevation is chronic are considered more true to the chronic condition of human glaucoma, in practice many patients with glaucoma continue to progress even when IOP is controlled (Ederer et al, 2004; Heijl et al, 2002). Therefore, a mouse model in which IOP elevation is transient is very useful in understanding pathologic degenerative changes in RGCs that occur even once IOP is normalized, or in modeling acute angle closure crisis or intermittent angle closure, wherein the IOP is typically transiently elevated.…”

Section: Structural and Functional Perturbations Of Rgc Types In Ementioning

confidence: 99%

Who’s lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma

Santina

Ou²

2017

Experimental Eye Research

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The purpose of this article is to summarize our current knowledge about the susceptibility of specific retinal ganglion cell (RGC) types in experimental glaucoma, and to delineate the initial morphological and functional alterations that occur in response to intraocular pressure (IOP) elevation. There has been debate in the field as to whether RGCs with large somata and axons are more vulnerable, with definitive conclusions still in progress because of the wide diversity of RGC types. Indeed, it is now estimated that there are greater than 30 different RGC types, and while we do not yet understand the complete details, we discuss a growing body of work that supports the selective vulnerability hypothesis of specific RGC types in experimental glaucoma. Specifically, structural and functional degeneration of various RGC types have been examined across different rodent models of experimental glaucoma (acute vs. chronic) and different strains, and an emerging consensus is that OFF RGCs appear to be more vulnerable to IOP elevation compared to ON RGCs. Understanding the mechanisms by which this selective vulnerability manifests across different RGC types should lead to novel and improved strategies for neuroprotection and neuroregeneration in glaucoma.

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The advanced glaucoma intervention study (AGIS)*113. Comparison of treatment outcomes within race: 10-year results

Cited by 179 publications

References 44 publications

Primary Open-Angle Glaucoma Genetics in African Americans

Primary Open-Angle Glaucoma Genetics in African Americans

Intraocular Pressure Control after Implantation of an Ahmed Glaucoma Valve in Eyes with a Failed Trabeculectomy

Who’s lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma

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