The adult eosinophilic oesophagitis quality of life questionnaire: a new measure of health-related quality of life

Taft, Tiffany; Kern, Emily; Kwiatek, Monika A.; Hirano, Ikuo; Gonsalves, Nirmala; Keefer, Laurie

doi:10.1111/j.1365-2036.2011.04791.x

Cited by 106 publications

(104 citation statements)

References 33 publications

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“…Patients may have stress over their symptoms, fear of food impaction and stigma over this relatively new diagnosis. Some adult patients may modify their eating behavior or avoid social situations where eating is involved so as to avoid a food impaction [10]. This behavioral modification may lead to a delay in the time to seek medical attention in some adults, leading to a delay in diagnosis.…”

Section: Natural Historymentioning

confidence: 99%

Distinct Features in the Clinical Presentations of Eosinophilic Esophagitis in Children and Adults: Is This the Same Disease?

Gonsalves¹

2014

Dig Dis

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Recent consensus guidelines define eosinophilic esophagitis (EoE) as a chronic, immune/antigen-mediated esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Adults with EoE typically present with dysphagia, food impaction and reflux symptoms, while children primarily present with refractory reflux, abdominal pain, vomiting and growth failure. Endoscopic features are also somewhat different in adults and children. Adult patients often present with fibrostenotic features of EoE including rings, strictures and narrow-caliber esophagus, while children present with inflammatory features of EoE including edema, white exudates and furrowing. Despite these differences in symptom and endoscopic presentation, many similarities exist between the two groups suggesting that this is the same disease in both children and adults. First, atopic history and genetic predisposition have been demonstrated in both groups. Most convincing is that both adults and children respond to food allergen avoidance, implicating a common etiology in the pathogenesis of this disease. While additional data is needed to better understand the natural history of EoE, preliminary data suggests that EoE is the same disease in adults and children, but with different phenotypic presentations.

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Section: Natural Historymentioning

confidence: 99%

Distinct Features in the Clinical Presentations of Eosinophilic Esophagitis in Children and Adults: Is This the Same Disease?

Gonsalves¹

2014

Dig Dis

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“…In a recent study relying on semistructured interviews regarding adult patients' experiences with the illness, patients expressed their concerns about the disease, their difficulty swallowing and the impact of EoE on their social interactions [47]. As a result of these findings, these same researchers developed the Adult Eosinophilic oesophagitis QoL questionnaire as a reliable, disease-specific measure of health-related QoL based on 37 items with five subscales: eating/dietary impact, social impact, emotional impact, disease anxiety and choking anxiety [48].…”

Section: Quality Of Life and Psychosocial Repercussionsmentioning

confidence: 99%

Adult versus pediatric eosinophilic esophagitis: important differences and similarities for the clinician to understand

Lucendo

Sánchez-Cazalilla

2012

Expert Review of Clinical Immunology

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“…There exist several reasons for treating active EoE: first, to reduce EoE-related symptoms and to improve EoE-related quality of life [18,19], and second, in the long run, to reduce or prevent esophageal remodeling processes that are associated with stricture formation and food bolus impaction. The therapy options for treating EoE can be summarized as the "3 D's," which stands for "drugs, diet, and dilation."…”

Section: Key Points On Eosinophilic Esophagitismentioning

confidence: 99%

Cohort Profile: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS)

Safroneeva

Saner²,

Rossel³

et al. 2017

Inflamm Intest Dis

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Background and Aims: The prospective, observational Swiss Eosinophilic Esophagitis Cohort Study (SEECS) was set up in 2015 with the following goals in mind: (1) to provide up-to-date epidemiologic data; (2) to assess the appropriateness of care; (3) to evaluate the psychosocial impact; and (4) to foster translational research projects. Data capture relies on validated instruments to assess disease activity and focuses on epidemiologic variables and biosamples (esophageal biopsies and blood specimens). An annual inclusion of 70 new patients with eosinophilic esophagitis (EoE) or proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is intended. We herein describe the SEECS cohort profile. Methods: The SEECS includes adult patients (age ≥18 years) with EoE or PPI-REE diagnosed according to published criteria. After inclusion, the patients are typically seen once a year for a clinical and endoscopic/histologic follow-up examination. Data are captured using validated questionnaires. Biosamples from patients with gastroesophageal reflux disease (GERD) and controls with a healthy esophagus are collected as well. Results: From January 2016 to July 2017, a total of 111 patients with EoE and 10 patients with PPI-REE were recruited. In addition, esophageal biopsies and blood samples from 11 patients with GERD and 20 controls with a healthy esophagus were collected. The mean age of the patients with EoE and those with PPI-REE was 39.6 ± 12.9 and 44.6 ± 15.6 years, respectively. A male predominance was found among both the patients with EoE (77.5%) and those with PPI-REE (70%). Concomitant allergic disorders were found in 79.3% of the patients with EoE and 90% of the patients with PPI-REE. At inclusion, the EoE patients were treated with the following therapeutic regimens: no therapy (0.9%), PPI (36%), swallowed topical corticosteroids (82.9%), elimination diets (15.3%), and esophageal dilation (19.8%). Conclusions: The SEECS is the first national cohort study of patients with EoE or PPI-REE. The SEECS will provide up-to-date epidemiologic data and foster translational research projects.

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The adult eosinophilic oesophagitis quality of life questionnaire: a new measure of health-related quality of life

Cited by 106 publications

References 33 publications

Distinct Features in the Clinical Presentations of Eosinophilic Esophagitis in Children and Adults: Is This the Same Disease?

Distinct Features in the Clinical Presentations of Eosinophilic Esophagitis in Children and Adults: Is This the Same Disease?

Adult versus pediatric eosinophilic esophagitis: important differences and similarities for the clinician to understand

Cohort Profile: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS)

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