The adsorption behaviour of carbon nanodots modulated by cellular membrane potential

Zhang, Shuyuan; Xiao, Chang-Qing; He, Huijuan; Xu, Zong‐Xiang; Wang, Beibei; Chen, Xueqin; Cao, Li; Jiang, Bingbing; Liu, Yi

doi:10.1039/c9en00991d

Cited by 12 publications

(8 citation statements)

References 42 publications

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“…The morphology of N 2 H 4 -CDs is recorded by high-resolution TEM (HRTEM). The HRTEM images display that the N 2 H 4 -CDs are quasi-spherical with an average size of 3.8 nm, which is quite close to that of the previous work (Figures C and S1C). Moreover, the N 2 H 4 -CDs show crystalline nature with an obvious lattice fringe at 0.21 nm, which is related to the (100) in-plane lattice spacing of graphite (inset of Figure C).…”

Section: Resultssupporting

confidence: 87%

Red-Emissive Carbon Dots Combined with Ferric Ions for Detection of Total Antioxidant Capacity in Food

Luo

Liu

Sun

et al. 2023

ACS Appl. Nano Mater.

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In general, the total antioxidant capacity (TAC) in food is vital for evaluating the quality of antioxidant food and health monitoring. Most studies about the access of the TAC in food are mainly focused on typical colorimetric strategies. Herein, a simple and sensitive strategy for TAC in beverages and fruit has been proposed based on amino/hydroxyl-functionalized carbon dots (N 2 H 4 -CDs) and Fe 3+ . The fluorescence (FL) of N 2 H 4 -CDs at 650 nm can be effectively and selectively quenched via the formation of the nonfluorescence complex (Fe 3+ /N 2 H 4 -CDs). Moreover, the FL of N 2 H 4 -CDs is concentrated in the red region, which can eliminate the interference in complex biological environments. Interestingly, based on the theoretical calculations of density functional theory (DFT), we have confirmed that the surface amino and hydroxyl play an essential role in selective association with Fe 3+ , resulting in effective quenching. Moreover, because Fe 3+ can be reduced by antioxidants to Fe 2+ , the quenched FL of N 2 H 4 -CDs can be restored in the presence of ascorbic acid (AA) and glutathione (GSH). Therefore, the typical antioxidants (AA) and especially certain thiol antioxidants (GSH) can also be analyzed by the proposed strategy. More importantly, we have proved that this strategy is successfully utilized for analyzing the TAC in beverages and fruit.

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Section: Resultssupporting

confidence: 87%

Red-Emissive Carbon Dots Combined with Ferric Ions for Detection of Total Antioxidant Capacity in Food

Luo

Liu

Sun

et al. 2023

ACS Appl. Nano Mater.

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“…In the presence of negatively charged FA CNDs, the tilt angle of the DLPC headgroup can be altered to facilitate the electrostatic attraction forces between the dopants and the quaternary ammonium cation. 99,100 Furthermore, the oxygen-containing phosphate groups with lone-pair electrons appear as acceptors (bases) in the formation of hydrogen bonds with the protic moieties of FA CNDs (e.g., amino or hydroxyl groups). 101 The fluorescence microscopic studies indicated that FA CNDs are present within the whole volume of MFs (with a high content of CNDs in the water core and lower contribution in the multilayered walls).…”

Section: One-photon Excited Fluorescence Imaging Of Mfsmentioning

confidence: 99%

Strongly Emitting Folic Acid-Derived Carbon Nanodots for One- and Two-Photon Imaging of Lyotropic Myelin Figures

Benkowska-Biernacka

Mucha

Firlej

et al. 2023

ACS Appl. Mater. Interfaces

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Non-invasive imaging of morphological changes in biologically relevant lipidic mesophases is essential for the understanding of membrane-mediated processes. However, its methodological aspects need to be further explored, with particular attention paid to the design of new excellent fluorescent probes. Here, we have demonstrated that bright and biocompatible folic acid-derived carbon nanodots (FA CNDs) may be successfully applied as fluorescent markers in one- and two-photon imaging of bioinspired myelin figures (MFs). Structural and optical properties of these new FA CNDs were first extensively characterized; they revealed remarkable fluorescence performance in linear and non-linear excitation regimes, justifying further applications. Then, confocal fluorescence microscopy and two-photon excited fluorescence microscopy were used to investigate a three-dimensional distribution of FA CNDs within the phospholipid-based MFs. Our results showed that FA CNDs are effective markers for imaging various forms and parts of multilamellar microstructures.

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“…Besides bacterial cells, the nano‐bio interactions between CPDs and membrane of mammalian cells have also been studied very recently. [ 32 ] We mainly focused on the impacts of trans‐ membrane potential on their adsorption behavior, because different cell possesses different membrane potential. We have found that depolarized cells with lower membrane potential prevent the adsorption of CPDs, while more CPDs can be adsorbed by hyperpolarized cells with higher membrane potential, regardless of cell types (NIH3T3 or MCF‐7) (Figure 3b).…”

Section: The Nano‐bio Interactions Of Cpds At Nano‐cellular Levelmentioning

confidence: 99%

The Behavior of Carbonized Polymer Dots at the Nano‐Bio Interface and Their Luminescent Mechanism: A Physical Chemistry Perspective

Liu

2021

Chin. J. Chem.

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Carbonized polymer dots (CPDs) have been widely applied in biomedical fields, such as imaging, diagnosis and drug delivery. Since the complex, non‐equilibrated and dynamic nature of biological systems inevitably affect the predesigned properties of CPDs, then efficiency and ultimate outcome of CPDs in biological identity will be transformed by the ubiquitous nano‐bio interactions. Herein, our recent progress about elucidating the behavior of CPDs at nano‐bio interface from the perspective of physical chemistry has been summarized in the review, mainly at the bio‐macromolecular, cellular membrane and cellular levels, which is crucial for characterize their relative cytotoxicity and clinical transformation. Moreover, we mainly focused on the quantitative relationship of nano‐bio interactions between CPDs with biological identity and related thermodynamics parameters during this process is also obtained from advanced isothermal titration calorimetry technique. Finally, our recent study about the photoluminescence origin is also included in this review, which favors modulating the photoluminescence of CPDs. What is the most favorite and original chemistry developed in your research group? Chemical thermodynamic nature of chemical and biological process. How do you get into this specific field? Could you please share some experiences with our readers? In 2003, several articles from Science, Nature and Nature Biotechnology discussed the potential side effects of nanomaterials on the human health and environment. At the same time, Prof. Daiwen Pang developed QDs for biolabling, and I (Prof. Yi Liu) began to pay attention to the effect of QDs on living things. In 2006, we obtained the Innovation Research Groups of NSFC (20621502), and in this project, I was responsible for the biological effect of nanoprobe. How do you keep balance between research and family? 90% of my time for research work, and 10% of my time for family things. How do you supervise your students? First, according to the students’ interests, I will give them some new and important papers to read, and then discuss with them about their research field. We will discuss the research progress at any time, and we have seminar every week. What is the most important personality for scientific research? Curiosity, power of understanding. What's your hobbies? What's your favorite book(s)? My hobbies are reading and badminton. My favorite books are Physical Chemistry (Edited by Xiancai Fu) and Organic Chemistry (4th Edited by David Klein).

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The adsorption behaviour of carbon nanodots modulated by cellular membrane potential

Abstract: A schematic comparison of the adsorption behavior of CDs on liposomes and cellular membranes.

Cited by 12 publications

References 42 publications

Red-Emissive Carbon Dots Combined with Ferric Ions for Detection of Total Antioxidant Capacity in Food

Red-Emissive Carbon Dots Combined with Ferric Ions for Detection of Total Antioxidant Capacity in Food

Strongly Emitting Folic Acid-Derived Carbon Nanodots for One- and Two-Photon Imaging of Lyotropic Myelin Figures

The Behavior of Carbonized Polymer Dots at the Nano‐Bio Interface and Their Luminescent Mechanism: A Physical Chemistry Perspective

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