The Adipose Tissue Macrophages Central to Adaptive Thermoregulation

Rahman, Md. Shamim; Jun, Hee-Jin

doi:10.3389/fimmu.2022.884126

Cited by 16 publications

(11 citation statements)

References 105 publications

(117 reference statements)

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“…Based on our observations, we suggest that the reported cold-induced accumulation of adiponectin in adipose tissue [39] amplifies the effects of SNS activation by enhancing the sympathetic innervation. While M2-type macrophages may not be essential for enhancing the catecholamine production [51], they may still play an important role in thermogenic activation of adipose tissue as recently reviewed in [52].…”

Section: Adiponectin and Metabolic Activity Of White And Brown Adipoc...mentioning

confidence: 99%

Adiponectin stimulates Sca1+CD34−-adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue

Bauzá-Thorbrügge,

Vujičić,

Chanclón

et al. 2024

Metabolism

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Section: Adiponectin and Metabolic Activity Of White And Brown Adipoc...mentioning

confidence: 99%

Adiponectin stimulates Sca1+CD34−-adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue

Bauzá-Thorbrügge,

Vujičić,

Chanclón

et al. 2024

Metabolism

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“…[ 151b,152 ] Mechanistically, Plexin A4 overexpressed in Mecp2‐deleted CX3CR1 + macrophages seemed to interact with and block the outgrowth of Semaphorin 6A‐positive sympathetic axons in the tissue. [ 151b,153 ]…”

Section: The Sympathetic Innervation and Immune Milieu In Adipose Tis...mentioning

confidence: 99%

The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues

Ren,

Hua,

Cao

et al. 2023

Advanced Science

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Sympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important functions in metabolic activities. Additionally, the immune system has long been studied for its essential roles in metabolic health and diseases. In this review, the aim is to provide an overview of the current research progress on the sympathetic regulation of key metabolic organs, including the pancreas, liver, intestine, and adipose tissues. In particular, efforts are made to highlight the critical roles of the peripheral nervous system and its potential interplay with immune components. Overall, it is hoped to underscore the importance of studying metabolic organs from a comprehensive and interconnected perspective, which will provide valuable insights into the complex mechanisms underlying metabolic regulation and may lead to novel therapeutic strategies for metabolic diseases.

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“…Furthermore, the secretion of IL-27 appears to be a major pathway of promoting thermogenesis in fat cells [ 8 ]. Macrophages contribute to the regulation of thermogenesis in response to cold exposure [ 9 ]. There is no homogeneous distribution of macrophage subtypes.…”

Section: Main Textmentioning

confidence: 99%

Obese visceral fat tissue inflammation: from protective to detrimental?

Kolb

2022

BMC Med

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Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune activation for clearing the tissue from an infectious agent. It is the loss of adipocyte metabolic homeostasis that causes activation of resident immune cells for supporting tissue functions and regaining homeostasis. Initially, the excess influx of lipids and glucose in the context of overnutrition is met by adipocyte growth and proliferation. Eventual lipid overload of hypertrophic adipocytes leads to endoplasmic reticulum stress and the secretion of a variety of signals causing increased sympathetic tone, lipolysis by adipocytes, lipid uptake by macrophages, matrix remodeling, angiogenesis, and immune cell activation. Pro-inflammatory signaling of adipocytes causes the resident immune system to release increased amounts of pro-inflammatory and other mediators resulting in enhanced tissue-protective responses. With chronic overnutrition, these protective actions are insufficient, and death of adipocytes as well as senescence of several tissue cell types is seen. This structural damage causes the expression or release of immunostimulatory cell components resulting in influx and activation of monocytes and many other immune cell types, with a contribution of stromal cells. Matrix remodeling and angiogenesis is further intensified as well as possibly detrimental fibrosis. The accumulation of senescent cells also may be detrimental via eventual spread of senescence state from affected to neighboring cells by the release of microRNA-containing vesicles. Obese visceral fat inflammation can be viewed as an initially protective response in order to cope with excess ambient nutrients and restore tissue homeostasis but may contribute to tissue damage at a later stage.

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The Adipose Tissue Macrophages Central to Adaptive Thermoregulation

Cited by 16 publications

References 105 publications

Adiponectin stimulates Sca1+CD34−-adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue

Adiponectin stimulates Sca1+CD34−-adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue

The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues

Obese visceral fat tissue inflammation: from protective to detrimental?

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