The adipokinetic hormone of Mantodea in comparison to other Dictyoptera

GÄde, Gerd; Marco, Heather G.

doi:10.1002/arch.21376

Cited by 4 publications

(2 citation statements)

References 46 publications

(62 reference statements)

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“…N: number of AKH neuropeptide sequences. Mantodea AKH (Emppe‐AKH; Gäde and Marco (2017)) is used as an outgroup.…”

Section: Resultsmentioning

confidence: 99%

Comparative analysis of adipokinetic hormones and their receptors in Blattodea reveals novel patterns of gene evolution

Jiang,

Marco,

Scheich

et al. 2023

Insect Molecular Biology

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Adipokinetic hormone (AKH) is a neuropeptide produced in the insect corpora cardiaca that plays an essential role in mobilising carbohydrates and lipids from the fat body to the haemolymph. AKH acts by binding to a rhodopsin‐like G protein‐coupled receptor (GPCR), the adipokinetic hormone receptor (AKHR). In this study, we tackle AKH ligand and receptor gene evolution as well as the evolutionary origins of AKH gene paralogues from the order Blattodea (termites and cockroaches). Phylogenetic analyses of AKH precursor sequences point to an ancient AKH gene duplication event in the common ancestor of Blaberoidea, yielding a new group of putative decapeptides. In total, 16 different AKH peptides from 90 species were obtained. Two octapeptides and seven putatively novel decapeptides are predicted for the first time. AKH receptor sequences from 18 species, spanning solitary cockroaches and subsocial wood roaches as well as lower and higher termites, were subsequently acquired using classical molecular methods and in silico approaches employing transcriptomic data. Aligned AKHR open reading frames revealed 7 highly conserved transmembrane regions, a typical arrangement for GPCRs. Phylogenetic analyses based on AKHR sequences support accepted relationships among termite, subsocial (Cryptocercus spp.) and solitary cockroach lineages to a large extent, while putative post‐translational modification sites do not greatly differ between solitary and subsocial roaches and social termites. Our study provides important information not only for AKH and AKHR functional research but also for further analyses interested in their development as potential candidates for biorational pest control agents against invasive termites and cockroaches.

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“…N: number of AKH neuropeptide sequences. Mantodea AKH (Emppe‐AKH; Gäde and Marco (2017)) is used as an outgroup.…”

Section: Resultsmentioning

confidence: 99%

Comparative analysis of adipokinetic hormones and their receptors in Blattodea reveals novel patterns of gene evolution

Jiang,

Marco,

Scheich

et al. 2023

Insect Molecular Biology

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“…The black and red frog hopper Cercopis vulnerata produces two very similar octapeptide AKHs: Peram-CAH-I was shown by mass spectrometry (17), and we identified Emppe-AKH (pEVNFTPNWa) from the frog hopper's transcriptome (Table 1). Emppe-AKH had previously been found in the CC of the praying mantis Empusa pennata and later from six further species of the order Mantodea (136). Bioinformatic searches revealed a pair of AKHs in a third cercopoid species, Prosapia bicincta, viz.…”

Section: Suborder Auchenorrhyncha Superfamily Cercopoideamentioning

confidence: 97%

The Adipokinetic Peptides of Hemiptera: Structure, Function, and Evolutionary Trends

GÄde

Marco

2022

Front. Insect Sci.

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The Hemiptera comprise the most species-rich order of the hemimetabolous insects. Members of a number of superfamilies, most notably especially the more basal ones such as white flies, psyllids and aphids, belong to the most destructive agricultural insects known worldwide. At the other end of the phylogenetic tree are hemipterans that are notorious medical pests (e.g. kissing bugs). Most of the hemipteran species are good flyers, and lipid oxidation plays a pivotal role to power the contraction of flight muscles and, in aquatic water bugs, also deliver the ATP for the extensive swimming action of the leg muscles. Mobilization of stored lipids (mostly triacylglycerols in the fat body) to circulating diacylglycerols in the hemolymph is regulated by a set of small neuropeptides, the adipokinetic hormones (AKHs). We searched the literature and publicly available databases of transcriptomes and genomes to present here AKH sequences from 191 hemipteran species. Only few of these peptides were sequenced via Edman degradation or mass spectrometry, and even fewer were characterized with molecular biology methods; thus, the majority of the AKHs we have identified by bioinformatics are merely predicted sequences at this stage. Nonetheless, a total of 42 AKH primary sequences are assigned to Hemiptera. About 50% of these structures occur also in other insect orders, while the remaining 50% are currently unique for Hemiptera. We find 9 novel AKHs not shown to be synthesized before in any insect. Most of the hemipteran AKHs are octapeptides (28) but there is an impressive number of decapeptides (12) compared to other speciose orders such as Diptera and Lepidoptera. We attempt to construct a hypothetical molecular peptide evolution of hemipteran AKHs and find quite a bit of overlapping with current phylogenetic ideas of the Hemiptera. Lastly, we discuss the possibility to use the sequence of the aphid AKH as lead peptide for the research into a peptide mimetic fulfilling criteria of a green insecticide.

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The adipokinetic hormone of the coleopteran suborder Adephaga: Structure, function, and comparison of distribution in other insects

GÄde

Marco

2017

Arch Insect Biochem Physiol

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The aim of the current study is to identify the adipokinetic hormone(s) (AKHs) of a basal suborder of the species-rich Coleoptera, the Adephaga, and possibly learn more about the ancestral AKH of beetles. Moreover, we wanted to compare the ancestral AKH with AKHs of more advanced beetles, of which a number are pest insects. This would allow us to assess whether AKH mimetics would be suitable as insecticides, that is, be harmful to the pest species but not to the beneficial species. Nine species of the Adephaga were investigated and all synthesize only one octapeptide in the corpus cardiacum, as revealed by Edman degradation sequencing techniques or by mass spectrometry. The amino acid sequence pGlu-Leu-Asn-Phe-Ser-Thr-Gly-Trp corresponds to Schgr-AKH-II that was first identified in the desert locust. It is assumed that Schgr-AKH-II-the peptide of a basal beetle clade-is the ancestral AKH for beetles. Some other beetle families, as well as some Hymenoptera (including honey bees) also contain this peptide, whereas most of the pest beetle species have different AKHs. This argues that those peptides and their receptors should be explored for developing mimetics with insecticidal properties. A scenario where Schgr-AKH-II (the only AKH of Adephaga) is used as basic molecular structure to derive almost all other known beetle AKHs via single step mutations is very likely, and supports the interpretation that Schgr-AKH-II is the ancestral AKH of Coleoptera.

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The adipokinetic hormone of Mantodea in comparison to other Dictyoptera

Cited by 4 publications

References 46 publications

Comparative analysis of adipokinetic hormones and their receptors in Blattodea reveals novel patterns of gene evolution

Comparative analysis of adipokinetic hormones and their receptors in Blattodea reveals novel patterns of gene evolution

The Adipokinetic Peptides of Hemiptera: Structure, Function, and Evolutionary Trends

The adipokinetic hormone of the coleopteran suborder Adephaga: Structure, function, and comparison of distribution in other insects

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