The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages

Fu, Yue; Luo, Nanlan; Lopes‐Virella, Maria F.; Garvey, W. Timothy

doi:10.1016/s0021-9150(02)00305-2

Cited by 170 publications

(132 citation statements)

References 39 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…In addition, AFABP-deficient mice are resistant to several inflammatory disorders, including allergic airway inflammation [45] and experimental autoimmune encephalomyelitis/multiple sclerosis [46]. Several proinflammatory stimuli induce AFABP production, including phorbol myristate acetate, oxidised (ox)LDL and toll-like receptor (TLR) agonists [4,35,47,48]. Among these, oxLDL upregulates AFABP during the transformation of macrophages into foam cells [4].…”

Section: The Role Of Afabp In the Pathogenesis Of Atherosclerosismentioning

confidence: 99%

“…Several proinflammatory stimuli induce AFABP production, including phorbol myristate acetate, oxidised (ox)LDL and toll-like receptor (TLR) agonists [4,35,47,48]. Among these, oxLDL upregulates AFABP during the transformation of macrophages into foam cells [4]. This AFABP elevation involves activation of PPARγ by components of oxLDL that function as PPARγ ligands [4].…”

Section: The Role Of Afabp In the Pathogenesis Of Atherosclerosismentioning

confidence: 99%

“…Among these, oxLDL upregulates AFABP during the transformation of macrophages into foam cells [4]. This AFABP elevation involves activation of PPARγ by components of oxLDL that function as PPARγ ligands [4]. Lipopolysaccharides (LPS) are potent TLR4 agonists that induce AFABP production in macrophages [47].…”

Section: The Role Of Afabp In the Pathogenesis Of Atherosclerosismentioning

confidence: 99%

“…AFABP accounts for up to 6% of total cytosolic protein in cultured differentiated fat cells [3]. In addition to production in adipocytes, AFABP is also produced in significant amounts in macrophages [4] and endothelial cells [5].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Adipocyte fatty acid binding protein: a novel adipokine involved in the pathogenesis of metabolic and vascular disease?

2012

View full text Add to dashboard Cite

Adipocyte fatty acid binding protein (AFABP, also known as aP2 and FABP4) has recently been introduced as a novel fat-derived circulating protein. AFABP serum concentrations are positively correlated with markers of the metabolic syndrome and vascular disease in various cross-sectional and interventional studies. Furthermore, a small set of prospective studies indicates that high AFABP serum levels at baseline predict the risk for metabolic and vascular morbidity and mortality. Studies in Afabp (also known as Fabp4) knockout mice and AFABP inhibitortreated animals suggest that total AFABP promotes insulin resistance, hypertriacylglycerolaemia and atherosclerosis by ligand/ligand delivery, as well as ligand-independent mechanisms. In contrast, the pathophysiological significance of circulating AFABP and the mechanisms leading to its release remain to be established. The current review summarises recent findings on the regulation and potential role of AFABP in metabolic and vascular disease.

show abstract

Section: The Role Of Afabp In the Pathogenesis Of Atherosclerosismentioning

confidence: 99%

Section: The Role Of Afabp In the Pathogenesis Of Atherosclerosismentioning

confidence: 99%

Section: The Role Of Afabp In the Pathogenesis Of Atherosclerosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adipocyte fatty acid binding protein: a novel adipokine involved in the pathogenesis of metabolic and vascular disease?

2012

View full text Add to dashboard Cite

show abstract

“…aP2 is expressed in adipocytes and macrophages and has been demonstrated in foam cells in human atherosclerotic plaque [56]. aP2 −/− mice are obese but protected against insulin resistance [57].…”

Section: Fatty Acid-binding Protein Ap2mentioning

confidence: 99%

Mechanisms by which diabetes increases cardiovascular disease

Gleissner

Galkina

Nadler

et al. 2007

Drug Discovery Today: Disease Mechanisms

View full text Add to dashboard Cite

Diabetes mellitus is one of the major risk factors for cardiovascular disease which is the leading cause of death in the U.S. Increasing prevalence of diabetes and diabetic atherosclerosis makes identification of molecular mechanisms by which diabetes promotes atherogenesis an important task. Targeting common pathways may ameliorate both diseases. This review focuses on well known as well as newly discovered mechanisms which may represent promising therapeutic targets.

show abstract

Molecular mechanisms of hypolipidemic effects of curcumin

2013

View full text Add to dashboard Cite

Recent evidence suggests potential benefits from phytochemicals and micronutrients in reducing the elevated oxidative and lipid-mediated stress associated with inflammation, obesity, and atherosclerosis. These compounds may either directly scavenge reactive oxygen or nitrogen species or they may modulate the activity of signal transduction enzymes leading to changes in the expression of antioxidant genes. Alternatively, they may reduce plasma lipid levels by modulating lipid metabolic genes in tissues and thus reduce indirectly lipid-mediated oxidative and endoplasmic reticulum stress through their hypolipidemic effect. Here we review the proposed molecular mechanisms by which curcumin, a polyphenol present in the rhizomes of turmeric (Curcuma longa) spice, influences oxidative and lipid-mediated stress in the vascular system. At the molecular level, mounting experimental evidence suggests that curcumin may act chemically as scavenger of free radicals and/or influences signal transduction (e.g., Akt, AMPK) and modulates the activity of specific transcription factors (e.g., FOXO1/3a, NRF2, SREBP1/2, CREB, CREBH, PPARγ, and LXRα) that regulate the expression of genes involved in free radicals scavenging (e.g., catalase, MnSOD, and heme oxygenase-1) and lipid homeostasis (e.g., aP2/FABP4, CD36, HMG-CoA reductase, and carnitine palmitoyltransferase-I (CPT-1)). At the cellular level, curcumin may induce a mild oxidative and lipid-metabolic stress leading to an adaptive cellular stress response by hormetic stimulation of these cellular antioxidant defense systems and lipid metabolic enzymes. The resulting lower oxidative and lipid-mediated stress may not only explain the beneficial effects of curcumin on inflammation, cardiovascular, and neurodegenerative disease, but may also contribute to the increase in maximum life-span observed in animal models.

show abstract

The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages

Cited by 170 publications

References 39 publications

Adipocyte fatty acid binding protein: a novel adipokine involved in the pathogenesis of metabolic and vascular disease?

Adipocyte fatty acid binding protein: a novel adipokine involved in the pathogenesis of metabolic and vascular disease?

Mechanisms by which diabetes increases cardiovascular disease

Molecular mechanisms of hypolipidemic effects of curcumin

Contact Info

Product

Resources

About