The adenosine, adrenergic and opioid pathways in the regulation of insulin secretion, beta cell proliferation and regeneration

Singh, Amitoj; Gibert, Yann; Dwyer, Karen M.

doi:10.1016/j.pan.2018.06.006

Cited by 13 publications

(12 citation statements)

References 129 publications

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“…The discrepancies may partially result from the inter-individual variations following consumption of high GL diets, which may be attributable to the differences in regions and dietary patterns [55]. GL-mediated responses in insulin secretion and glycemic control may also be regulated via pathophysiological pathways, such as the opioid system, especially in obese individuals [56,57]. However, our study found no evidence of effect modification on the associations between dietary GI and GL values and prevalence of dyslipidemia or hyperglycemia by region.…”

Section: Discussionmentioning

confidence: 99%

Associations between Dietary Glycemic Index and Glycemic Load Values and Cardiometabolic Risk Factors in Adults: Findings from the China Health and Nutrition Survey

Zhixin

Meng

et al. 2020

Nutrients

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Studies investigating the associations between dietary glycemic index (GI) and glycemic load (GL) values and cardiometabolic risk factors (CMRF) among Chinese populations are strikingly limited. To assess the associations between dietary GI and GL values and CMRF, including dyslipidemia, hyperglycemia, and hyperuricemia in Chinese adults, we extracted data of 7886 apparently healthy adults from the 2009 wave of the China Health and Nutrition Survey. Dietary GI and GL values were calculated using data collected from three consecutive 24 h dietary recalls. Fasting lipid, glucose, and uric acid concentrations were measured and CMRF were defined on the basis of established criteria. There were no significant associations between dietary GI values and CMRF, and analyzing the data by age, sex, body mass index (BMI), and region did not alter these results. Dietary GL values were positively associated with prevalence of hyperuricemia in all participants (Q4 compared with Q1: odds ratio (OR) = 1.46; 95% CI: 1.14, 1.87; p-trend = 0.0030) and prevalence of hypercholesterolemia in participants ≥ 60 years old (Q5 compared with Q1: OR = 1.72; 95% CI: 1.11, 2.68; p-trend < 0.0010). Higher dietary GL but not GI values were associated with increased prevalence of hyperuricemia in apparently healthy Chinese adults and hypercholesterolemia in older Chinese adults. Further studies are required to confirm the public health implication of these findings.

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Section: Discussionmentioning

confidence: 99%

Associations between Dietary Glycemic Index and Glycemic Load Values and Cardiometabolic Risk Factors in Adults: Findings from the China Health and Nutrition Survey

Zhixin

Meng

et al. 2020

Nutrients

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“…Previous studies have shown that ADA is an important enzyme that modulates the insulin bioactivity [ 6 , 27 , 28 ]. In addition, ADA is an important enzyme in regulating adenosine concentration by inactivation of adenosine, and adenosine plays a critical role in modulating glucose and insulin homeostasis and the pathophysiology of T2D [ 7 , 8 , 29 ]. Dhalla et al [ 30 ] revealed that adenosine A 1 receptor agonist decreased the levels of free fatty acids (FFA) and triglycerides and improved the insulin resistance induced by high-fat diet in mice.…”

Section: Discussionmentioning

confidence: 99%

“…ADA is an important enzyme that regulates the biological activity of insulin [ 5 , 6 ]. In addition, increasing evidence highlights that adenosine affects insulin secretion and insulin sensitivity, and also plays an important role in regulating islet cell function [ 7 , 8 ]. Serum ADA activity is strongly increased in autoimmune diseases, cancers and inflammatory diseases [ 4 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Inverse relationship between serum adenosine deaminase levels and islet beta cell function in patients with type 2 diabetes

Cao

Wang

et al. 2021

Diabetol Metab Syndr

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Objective Type 2 diabetes (T2D) is a chronic low-grade inflammatory disease, which characterized by islet beta cell dysfunction. Serum adenosine deaminase (ADA) is an important enzyme that regulates the biological activity of insulin, and its levels are greatly increased in inflammatory diseases with insulin resistance. The present study was designed to explore the relationship between serum ADA levels and islet beta cell function in patients with T2D. Methods This cross-sectional study recruited 1573 patients with T2D from the Endocrinology Department of the Affiliated Hospital 2 of Nantong University between 2015 and 2018. All participants were received serum ADA test and oral glucose tolerance test (OGTT). Insulin sensitivity index (assessed by Matsuda index using C-peptide, ISIM-cp), insulin secretion index (assessed by ratio of area under the C-peptide curve to glucose curve, AUCcp/glu) and islet beta cell function (assessed by insulin secretion-sensitivity index 2 using C-peptide, ISSI2cp) were derived from OGTT. And other clinical parameters, such as HbA1c, were also collected. Results It was showed that HbA1c was significantly increased, while ISIM-cp, AUCcp/glu and ISSI2cp significantly decreased, across ascending quartiles of serum ADA levels. Moreover, serum ADA levels were negatively correlated with ISSI2cp (r = − 0.267, p < 0.001). Furthermore, after adjusting for other clinical parameters by multiple linear regression analysis, serum ADA levels were still independently associated with ISSI2cp (β = − 0.125, t = − 5.397, p < 0.001, adjusted R2 = 0.459). Conclusions Serum ADA levels are independently associated with islet beta cell function in patients with T2D.

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“…In this study, the insulin domain of expression in zebrafish embryos decreased following exposure to bBCM-5 and -7, which may reflect a reduction in β-cell size or number. Decreased insulin levels following exogenous opioid administration have been observed and thought to be a consequence of insulin-signalling inhibition as a result of a direct crosstalk between the µ-opioid receptor and the insulin-signalling cascade ( Li et al, 2003 ; Singh et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

The protective effects of human milk derived peptides on the pancreatic islet biology

et al. 2020

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Several epidemiological studies support the protective role of breastfeeding in reducing the risk for type 1 diabetes. Human breast milk is the perfect nutrition for infants and contains many complex proteins, lipids and carbohydrates. In this study, we examined the physiological effects of human milk-derived opioid peptides, β-casomorphins (BCM), and compared them with bovine-milk-derived opioid peptides on pancreatic hormone regulation and β-cell regeneration. Exposure of wild-type zebrafish embryos to 50 µg/ml of human BCM-5 and -7 from 3 days post fertilisation until 6 days post fertilisation resulted in an increased insulin domain of expression while exposure to bovine BCM-5 and -7 significantly reduced the insulin domain of expression as analysed by whole-mount in situ hybridisation. These changes may be accounted for by reduced insulin expression or β-cell number and were mitigated by the µ-opioid receptor antagonist, naloxone. The effect of BCM on β-cell regeneration was assessed following ablation of β-cells in Tg (ins: CFP-NTR) zebrafish from 3 days post fertilisation to 4 days post fertilisation, followed by exposure of bovine and human BCM-5 and -7 (50 µg/ml) from 4 days post fertilisation until 7 days post fertilisation. The regenerative capacity of β-cells was not impeded following exposure to human BCM-5 and -7, whereas the capacity of β-cells to regenerate following bovine BCM-5 and -7 exposure was reduced. Our data suggest that human BCM-5 and -7 may promote β-cell development and enable the regeneration of β-cells, while the bovine-milk-derived peptides, BCM-5 and -7, play an opposite role. These data may provide some biological explanation for the protective effect of breastfeeding on the development of type 1 diabetes.

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The adenosine, adrenergic and opioid pathways in the regulation of insulin secretion, beta cell proliferation and regeneration

Cited by 13 publications

References 129 publications

Associations between Dietary Glycemic Index and Glycemic Load Values and Cardiometabolic Risk Factors in Adults: Findings from the China Health and Nutrition Survey

Associations between Dietary Glycemic Index and Glycemic Load Values and Cardiometabolic Risk Factors in Adults: Findings from the China Health and Nutrition Survey

Inverse relationship between serum adenosine deaminase levels and islet beta cell function in patients with type 2 diabetes

The protective effects of human milk derived peptides on the pancreatic islet biology

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