The Additive Effects of Ischemic Postconditioning and Cyclosporine-A on Nitric Oxide Activity and Functions of Diabetic Myocardium Injured by Ischemia/Reperfusion

Abstract

The present study indicated that IPostC or CsA failed to affect NO levels and failed to protect the diabetic myocardium against ischemia/reperfusion injury. Moreover, concomitant administration of CsA and IPostC at reperfusion can increase NO content and protect the diabetic myocardium.

Ischemic postconditioning provides cardioprotective and antiapoptotic effects against ischemia–reperfusion injury through iNOS inhibition in hyperthyroid rats

“…Similar to our study, it has been shown that the cardioprotective effects of IPost in declining IS are abolished in disease conditions such as diabetes (Badalzadeh et al, 2012), metabolic syndrome (Wagner et al, 2008), and hypercholesterolemia (Wu et al, 2015b). In line with our findings, it has been reported that in disease states, loss of IPost cardioprotection can be restored by the concomitant administration of specific inhibitors including iNOS inhibitors (Badalzadeh et al, 2012;Zaman et al, 2014).…”

Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning

“…Badalzadeh et al (2012) demonstrated that the isolated diabetic rat heart was resistant to cardioprotection by either ischemic postconditioning or cyclosporine-A alone, but with the combination of interventions, a significant reduction in infarct size was observed. In contrast, Fan et al (2012) found that atorvastatin was able to postcondition the diabetic heart, despite it being resistant to ischemic postconditioning; when given in combination, an additive cardioprotective effect was seen.…”

Troxerutin Protects Against Myocardial Ischemia/Reperfusion Injury Via Pi3k/Akt Pathway in Rats

“…A left thoracotomy was performed to expose the beating heart. The I/R animal model was established by ligation of the left anterior descending (LAD) coronary artery for 30 min followed by reperfusion for 45 min (by reopening of LAD) [21]. The chest was closed in layers, and the animals were allowed to recover.…”