The Additional Value of us to Mammography in the Diagnosis of Breast Cancer

Skaane, Per

doi:10.3109/02841859909175572

Cited by 27 publications

(14 citation statements)

References 16 publications

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“…This supports the interpretation of breast ultrasound with consideration of the mammography results where mammography has been performed. The clinical indication to perform both tests is a separate issue and has been discussed in other published work (1,3–6,8).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Knowledge of Mammography Findings on the Accuracy of Breast Ultrasound in Symptomatic Women

Houssami¹,

Irwig²,

Simpson³

et al. 2005

Breast Journal

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Breast ultrasound is generally interpreted with knowledge of the mammographic examination. This study examined the influence of knowledge of mammography findings on the accuracy of ultrasound in women with breast symptoms. Subjects were sampled from all women 25-55 years of age consecutively attending a breast clinic. This included all 240 women shown to have breast cancer and 240 age-matched women shown not to have cancer. Ultrasound films were prospectively reviewed and reported by two radiologists independent of each other and in a blinded manner. A two-phase design was used. In the first phase, the radiologists provided an opinion on the ultrasound films. In the second phase, the ultrasound films were reread with consideration of the corresponding mammographic examination. The accuracy of reading the ultrasound with and without knowledge of the findings on mammography was compared using sensitivity and specificity, and receiver operating characteristics (ROC) curves. Reporting the ultrasound with knowledge of mammography (compared to without mammography) improved sensitivity and reduced specificity for both radiologists. For one reader, sensitivity increased from 77.5% to 86.7% (p = 0.0002) and specificity decreased from 89.7% to 85.4% (p = 0.04). For the other reader, sensitivity increased from 81.3% to 87.5% (p = 0.0023) and specificity decreased from 87.1% to 85.0% (p = 0.27). ROC curves for both radiologists showed that reporting ultrasound with knowledge of mammography resulted in small (about 3%), but significant improvement in the area under the ROC curve. Our study indicates that knowledge of the findings of mammography improves the interpretation of breast ultrasound in symptomatic women.

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Section: Discussionmentioning

confidence: 99%

The Influence of Knowledge of Mammography Findings on the Accuracy of Breast Ultrasound in Symptomatic Women

Houssami¹,

Irwig²,

Simpson³

et al. 2005

Breast Journal

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“…Ultrasonography is more sensitive than mammography at detecting lesions in women with dense breasts910. However, ultrasonography does not detect most microcalcifications, which are the typical findings in ductal carcinoma in situ.…”

mentioning

confidence: 99%

Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy and Mammary Gland Fibroma

Wang

Sun

Guo

et al. 2014

Sci Rep

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The association between cancer and volatile organic metabolites in exhaled breaths has attracted increasing attention from researchers. The present study reports on a systematic study of gas profiles of metabolites in human exhaled breath by pattern recognition methods. Exhaled breath was collected from 85 patients with histologically confirmed breast disease (including 39 individuals with infiltrating ductal carcinoma, 25 individuals with cyclomastopathy and from 21 individuals with mammary gland fibroma) and 45 healthy volunteers. Principal component analysis and partial least squares discriminant analysis were used to process the final data. The volatile organic metabolites exhibited significant differences between breast cancer and normal controls, breast cancer and cyclomastopathy, and breast cancer and mammary gland fibroma; 21, 6, and 8 characteristic metabolites played decisive roles in sample classification, respectively (P < 0.05). Three volatile organic metabolites in the exhaled air, 2,5,6-trimethyloctane, 1,4-dimethoxy-2,3-butanediol, and cyclohexanone, distinguished breast cancer patients from healthy individuals, mammary gland fibroma patients, and patients with cyclomastopathy (P < 0.05). The identified three volatile organic metabolites associated with breast cancer may serve as novel diagnostic biomarkers.

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“…Many of the other studies to assess the use of additional imaging were done with symptomatic women or a combination of asymptomatic and symptomatic women and looked at the value of additional imaging with either a test set or as a retrospective review of specific cases [4,[37][38][39][40]. Most of the studies looked at the added value of ultrasound for detecting cancers, without looking at negative assessments or the effect of additional imaging on specificity.…”

Section: Discussionmentioning

confidence: 98%

The use of additional imaging increased specificity and decreased sensitivity in screening mammography

Geller¹,

Vacek²,

Skelly³

et al. 2005

Journal of Clinical Epidemiology

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The Additional Value of us to Mammography in the Diagnosis of Breast Cancer

Cited by 27 publications

References 16 publications

The Influence of Knowledge of Mammography Findings on the Accuracy of Breast Ultrasound in Symptomatic Women

The Influence of Knowledge of Mammography Findings on the Accuracy of Breast Ultrasound in Symptomatic Women

Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy and Mammary Gland Fibroma

The use of additional imaging increased specificity and decreased sensitivity in screening mammography

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