The addition of whole-body magnetic resonance imaging to body computerised tomography alters treatment decisions in patients with metastatic breast cancer

Kosmin, Michael; Makris, Andreas; Joshi, Priya V; Ah-See, Mei-Lin; Woolf, David; Padhani, Anwar R.

doi:10.1016/j.ejca.2017.03.001

Cited by 38 publications

(39 citation statements)

References 14 publications

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“…In literature, several studies used other diagnostic exams to verify the real presence of bone metastases, like CT, PET/CT, X-ray, or follow-up. However, no study used bone biopsy as a control [ 16 , 17 , 18 ].…”

Section: Diffusion-weighted Imaging (Dwi) Sequences In Bone Metastmentioning

confidence: 99%

Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review

et al. 2018

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Whole body magnetic resonance imaging (MRI) with diffusion-weighted imaging (WB-MRI-DWI) is currently emerging as a diagnostic technique in the evaluation of bone metastases from breast, prostate, lung, thyroid, and melanoma tumors. The most relevant articles regarding the detection of solid tumor bone metastases with MRI have been reviewed and cited. The imaging methods currently used in the detection of bone metastases are bone scintigraphy, computed tomography (CT), and positron emission tomography (PET/CT) with 2-deoxy-2-[fluorine-18] fluoro-d-glucose (18F-FDG PET/CT). WB-MRI-DWI allows qualitative and quantitative evaluation of focal lesions through signal intensity evaluation on DWI images and the reconstruction of the apparent diffusion coefficient (ADC) map. In prostate and breast cancer, WB-MRI-DWI is useful in assessing the response of bone lesions to therapy and to detecting early non-responders, while in lung cancer the method shows a similar sensitivity to 18F-FDG PET/CT in the detection of bone metastases. In bone metastases of thyroid tumors and melanoma, the WB-MRI-DWI shows a higher sensitivity when compared to 18F-FDG PET/CT. With a standardization of the WB-MRI-DWI protocol, this method seems to play an important role in the diagnosis of bone solid tumor metastases.

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Section: Diffusion-weighted Imaging (Dwi) Sequences In Bone Metastmentioning

confidence: 99%

Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review

et al. 2018

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“…Accurate imaging response evaluations of oncologic patients are sometimes notoriously difficult with conventional imaging techniques, especially in the case of bone lesions. In this setting, whole-body (WB)-DWI MRI has shown clinical value for the assessment of therapeutic response in patients with metastatic bone disease, multiple myeloma, and lymphoma [41,[43][44][45][46][47][48][49][50][51][52][53][54] (Figs. 6 and 7).…”

Section: Clinical Valuementioning

confidence: 99%

How clinical imaging can assess cancer biology

et al. 2019

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Human cancers represent complex structures, which display substantial inter-and intratumor heterogeneity in their genetic expression and phenotypic features. However, cancers usually exhibit characteristic structural, physiologic, and molecular features and display specific biological capabilities named hallmarks. Many of these tumor traits are imageable through different imaging techniques. Imaging is able to spatially map key cancer features and tumor heterogeneity improving tumor diagnosis, characterization, and management. This paper aims to summarize the current and emerging applications of imaging in tumor biology assessment.

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“…A recent study involving over 1000 patients suggests a sensitivity of 96% for the detection of skeletal metastases in prostate cancer . In advanced breast cancer, WBMRI is more sensitive in the detection of skeletal metastases requiring treatment alteration than 18 F‐fluordeoxyglucose / positron emission tomography / computed tomography (‐FDG PET/CT) . This allows more precise estimation of the overall tumor burden, which has important implications for prognosis and treatment.…”

Section: Wbmri Of the Bone Marrow In Malignancymentioning

confidence: 99%

“…52 In advanced breast cancer, WBMRI is more sensitive in the detection of skeletal metastases requiring treatment alteration than 18 F-fluordeoxyglucose / positron emission tomography / computed tomography ( 18 -FDG PET/CT). 53 This allows more precise estimation of the overall tumor burden, which has important implications for prognosis and treatment. Skeletal metastases have historically posed a challenge with regard to evaluating treatment response, as CT and scintigraphic findings are inconsistent and prone to misinterpretation.…”

Section: Wbmri In Bone Metastasesmentioning

confidence: 99%

Whole‐body MRI of bone marrow: A review

Hynes

Hughes

Cunningham

et al. 2019

Magnetic Resonance Imaging

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Technical advances in the last two decades have allowed rapid, high‐resolution whole‐body magnetic resonance imaging (WBMRI). MRI allows unparalleled visualization and detail in the imaging of bone marrow and surrounding soft tissues. The properties of nuclear magnetic resonance allow superb characterization of bone marrow constituents. WBMRI allows superb characterization of the different types of bone marrow and their natural evolution during the life cycle. Diffusion‐weighted WBMRI is an exciting development that adds functional information to anatomical detail. The mainstay of WBMRI for bone marrow abnormalities to date has centered upon staging multiple myeloma and other hematologic bone marrow conditions, and as a valuable tool in quantifying skeletal metastases. Increasingly, WBMRI is being utilized in a variety of additional malignant and nonmalignant conditions. Due to the absence of ionizing radiation, WBMRI represents a valuable screening tool in areas such as malignant transformation in hereditary multifocal exostoses or for the development of ischemic marrow insult in at‐risk patients. An additional novel area of use includes postmortem WBMRI for characterization of skeletal injuries. This article provides a state‐of‐the‐art and current review of WBMRI of the bone marrow and highlights potential future areas of development. Level of Evidence: 5 Technical Efficacy Stage: 3 J. MAGN. RESON. IMAGING 2019. J. Magn. Reson. Imaging 2019;50:1687–1701.

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The addition of whole-body magnetic resonance imaging to body computerised tomography alters treatment decisions in patients with metastatic breast cancer

Cited by 38 publications

References 14 publications

Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review

Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review

How clinical imaging can assess cancer biology

Whole‐body MRI of bone marrow: A review

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