The addition of the MEP amplitude of finger extension muscles to clinical predictors of hand function after stroke: A prospective cohort study

Bakker, C.D.; Massa, Mark; Daffertshofer, Andreas; Pasman, J.W.; Kuijk, Annette A. van; Kwakkel, Gert; Stegeman, Dick F.

doi:10.3233/rnn-180890

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…In another cohort study, Katrak et al ( 1998 ) found that initial active shoulder abduction noted on average 11 days after stroke onset, predicted good hand movement at 1 month and hand function at 1 and 2 months. Bakker et al ( 2019 ) even found that the ability of patients to voluntarily extend the fingers within 4 weeks after stroke was strongly related to Fugl-Meyer (FM) at 26 weeks after stroke, with no false-negative results and no additional value of the motor-evoked potential amplitude of the affected finger extension muscle for this clinical predictor. More recent studies have developed algorithms (also based on the scoring of SA and FE movements) to predict an individual’s potential for UL recovery within a few months post-stroke (Stinear et al, 2012 , 2017b ) and 2 years post-stroke (Smith et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…It should be noted that while the functional integrity of the CST originating from the primary motor cortex of the damaged hemisphere is believed to be necessary for the execution of distal upper-limb movements (hand and fingers, including FE) after stroke onset (Brodal, 2016 ; Stinear et al, 2017b ; Bakker et al, 2019 ), the brain structures underlying the capacity to execute proximal movements, like SA, are less clear. Also, while the amplitude of motor-evoked potentials (MEPs) recorded from FE muscles early after stroke onset correlates with late FM scores, it was claimed that MEPs lack a significant added value for prediction of long-term hand function over and above the clinical prediction method (Bakker et al, 2019 ). This however might result from stimulation power being insufficient to activate functionally depressed but structurally preserved cortical motor neurons or reflect recovery processes based on structure-function re-mapping and network reorganization, involving brain systems that are not directly connected to the corticospinal pathways.…”

Section: Introductionmentioning

confidence: 99%

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Lesion Topography Impact on Shoulder Abduction and Finger Extension Following Left and Right Hemispheric Stroke

Frenkel‐Toledo

Ofir-Geva

Soroker

2020

Front. Hum. Neurosci.

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The existence of shoulder abduction and finger extension movement capacity shortly after stroke onset is an important prognostic factor, indicating favorable functional outcomes for the hemiparetic upper limb (HUL). Here, we asked whether variation in lesion topography affects these two movements similarly or distinctly and whether lesion impact is similar or distinct for left and right hemisphere damage. Shoulder abduction and finger extension movements were examined in 77 chronic post-stroke patients using relevant items of the Fugl-Meyer test. Lesion effects were analyzed separately for left and right hemispheric damage patient groups, using voxel-based lesion-symptom mapping. In the left hemispheric damage group, shoulder abduction and finger extension were affected only by damage to the corticospinal tract in its passage through the corona radiata. In contrast, following the right hemispheric damage, these two movements were affected not only by corticospinal tract damage but also by damage to white matter association tracts, the putamen, and the insular cortex. In both groups, voxel clusters have been found where damage affected shoulder abduction and also finger extension, along with voxels where damage affected only one of the two movements. The capacity to execute shoulder abduction and finger extension movements following stroke is affected significantly by damage to shared and distinct voxels in the corticospinal tract in left-hemispheric damage patients and by damage to shared and distinct voxels in a larger array of cortical and subcortical regions in right hemispheric damage patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lesion Topography Impact on Shoulder Abduction and Finger Extension Following Left and Right Hemispheric Stroke

Frenkel‐Toledo

Ofir-Geva

Soroker

2020

Front. Hum. Neurosci.

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“…Recently, behavioral evaluation scales have been used as indicators of neurological recovery in animal models of CNS injury. The modified neurologic severity score 24 – 26 , the Basso, Beattie and Bresnahan locomotor scale method 6 , 10 , 11 , 27 – 29 , angle of inclined plane test 10 , 11 , 28 , 29 , and the Rotarod test 30 – 32 have been used as behavioral evaluation scales. While it is true that these behavioral evaluation scales can be measured easily, detailed quantification is difficult, whereas the evaluation of tcMEPs is quantified.…”

Section: Discussionmentioning

confidence: 99%

“…Transcranial electrical stimulation MEP (tcMEP) is currently one of the most popular intraoperative pyramidal tract monitoring methods in clinical neurosurgery 1 , 2 , spinal surgery 3 , 4 , and aortic surgery 5 . Evaluating intraoperative motor function with tcMEPs often provides information on strategies to preserve postoperative motor function and evaluate patients following nerve injury (e.g., stroke or spinal cord injury) 6 – 8 .…”

Section: Introductionmentioning

confidence: 99%

A novel bone-thinning technique for transcranial stimulation motor-evoked potentials in rats

Maeda

Otsuka

Mitsuhara

et al. 2021

Sci Rep

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Transcranial electrical stimulated motor-evoked potentials (tcMEPs) are widely used to evaluate motor function in humans, and even in animal studies, tcMEPs are used to evaluate neurological dysfunction. However, there is a dearth of reports on extended tcMEP recordings in both animal models and humans. Therefore, this study examined a new technique for stably recording tcMEPs over several weeks in six healthy female Sprague–Dawley rats. We thinned the skull bone using the skull base and spinal surgery technique to reduce electrical resistance for electrical stimulation. tcMEPs were recorded on days 1, 7, 14, 21, and 28 after surgery. The onset latency and amplitude of tcMEPs from the hindlimbs were recorded and evaluated, and histological analysis was performed. Stable amplitude and onset latency could be recorded over several weeks, and histological analysis indicated no complications attributable to the procedure. Thus, our novel technique allows for less invasive, safer, easier, and more stable extended tcMEP recordings than previously reported techniques. The presently reported technique may be applied to the study of various nerve injury models in rats: specifically, to evaluate the degree of nerve dysfunction and recovery in spinal cord injury, cerebral infarction, and brain contusion models.

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“…Ademais se destaca que a população acometida por um episódio de AVC apresenta inúmeras complicações, de ordem motora (problemas na mobilidade, fraqueza muscular, parestesia, hemiplegia, equilíbrio prejudicado, alterações na marcha), emocional/afetiva (depressão), cognitiva (déficit cognitivo), entre outras, resultantes de alteração na perfusão cerebral [10]. Dentre estas, destacamos as alterações nos membros superiores, que atingem 33% a 70% desses pacientes, pelo seu forte impacto sobre as atividades de vida diária [11][12]. Associado a isso, há o alto risco de re-hospitalização precoce e institucionalização, com consequências adversas em termos de custos socioeconômicos [13].…”

Section: Introductionunclassified

Biomarcadores relacionados à funcionalidade do membro superior de pessoas que sofreram acidente vascular cerebral: protocolo de revisão sistemática

Carrogi-Vianna,

Oliveira-Kumakura,

Garcia-Salazar

et al. 2024

Enferm Bras

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Objetivo: Determinar quais biomarcadores têm sido relacionados à funcionalidade do membro superior na fase aguda, subaguda ou crônica de pessoas que sofreram acidente vascular cerebral (AVC) isquêmico ou hemorrágico. Métodos: Protocolo de revisão sistemática, registrado no PROSPERO (CRD42021274244), com busca de dados sem corte de tempo na PubMed, PubMed PMC, Embase, Web of Science, Scopus, Cinahl e ProQuest. Os revisores avaliarão independentemente títulos, resumos e artigos de texto completo recuperados de bases de dados para identificar estudos potencialmente elegíveis. Os artigos relevantes serão avaliados quanto ao risco de viés e qualidade por meio do uso da ferramenta Quality In Prognosis Studies (QUIPS). A revisão incluirá estudos primários (original), do tipo Ensaios Controlados ou Observacionais (transversal, caso-controle ou estudos longitudinais) com análises de biomarcadores nas diferentes fases de AVC quanto à funcionalidade ou predição de recuperação. Serão excluídos pacientes com menos de 18 anos, diagnóstico de ataque isquêmico transitório e artigos que não explicitam os critérios de forma detalhada da avaliação dos biomarcadores. A qualidade e o risco de viés dos estudos serão avaliados de forma independente por dois pesquisadores. A síntese de dados será realizada utilizando um resumo narrativo e uma análise quantitativa. Modelos de meta-análise de efeitos aleatórios poderão ser empregados com base nas variáveis de resultados encontrados.

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The addition of the MEP amplitude of finger extension muscles to clinical predictors of hand function after stroke: A prospective cohort study

Cited by 7 publications

References 34 publications

Lesion Topography Impact on Shoulder Abduction and Finger Extension Following Left and Right Hemispheric Stroke

Lesion Topography Impact on Shoulder Abduction and Finger Extension Following Left and Right Hemispheric Stroke

A novel bone-thinning technique for transcranial stimulation motor-evoked potentials in rats

Biomarcadores relacionados à funcionalidade do membro superior de pessoas que sofreram acidente vascular cerebral: protocolo de revisão sistemática

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